{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:22:55Z","timestamp":1765610575864,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"unspecified","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,5,14]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peripheral artery disease (PAD) is a chronic condition causing arterial narrowing or blockage, leading to significant morbidity and mortality. Hybrid revascularisation combines open surgical and endovascular techniques to manage multilevel disease by addressing inflow and outflow obstructions. Despite increasing adoption, evidence on the long-term outcomes of these procedures remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the long-term outcomes of hybrid revascularisation procedures in PAD, including patency rates, limb salvage, survival, reintervention rates and complications, and to provide evidence-based insights for clinical practice and research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. It will include randomised controlled trials, cohort studies, case-control studies and large case series (\u226510 patients, with at least 1 year of follow-up) assessing adult patients undergoing hybrid revascularisation for PAD. Primary outcomes are patency rates, limb salvage and survival; secondary outcomes include complication rates, functional improvements and quality of life. Searches will be conducted in PubMed, Embase, Cochrane Library, CINAHL and ClinicalTrials.gov. Study selection, data extraction and quality assessment will be performed independently in duplicate by two reviewers. Meta-analyses with random-effects models will summarise findings where feasible, while narrative synthesis will address instances of insufficient data. Subgroup analyses will explore outcomes by demographics, lesion characteristics and procedural details. Risk of bias will be assessed using Cochrane and Newcastle-Ottawa tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval is not required. Findings will be published in peer-reviewed journals and presented at conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42024615809.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-096955","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:58:06Z","timestamp":1750316286000},"page":"e096955","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Short-term and long-term outcomes of hybrid revascularisation procedures in peripheral artery disease: a systematic review protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-3903","authenticated-orcid":false,"given":"Maram","family":"Darwish","sequence":"first","affiliation":[{"name":"Vascular Surgery, Cardiff and Vale University Health Board, Cardiff, UK"},{"name":"Health Education East Midlands, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huw Owain","family":"Davies","sequence":"additional","affiliation":[{"name":"South East Wales Vascular Network, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Morgan","sequence":"additional","affiliation":[{"name":"University Hospital of Wales, Cardiff, UK"},{"name":"The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Meecham","sequence":"additional","affiliation":[{"name":"South East Wales Vascular Network, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"2025121219273937000_15.6.e096955.1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41569-021-00663-9","article-title":"Update on the pathophysiology and medical treatment of peripheral artery disease","volume":"19","author":"Golledge","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"2025121219273937000_15.6.e096955.2","first-page":"357","article-title":"Contemporary Medical Management of Peripheral Arterial Disease","volume":"39","author":"Cook","year":"2025","journal-title":"Cardiovasc Drugs Ther"},{"key":"2025121219273937000_15.6.e096955.3","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11123131","article-title":"Cardiovascular Prognosis in Patients with Peripheral Artery Disease and Approach to Therapy","volume":"11","author":"Curcio","year":"2023","journal-title":"Biomedicines"},{"doi-asserted-by":"publisher","key":"2025121219273937000_15.6.e096955.4","DOI":"10.1007\/s00270-005-0296-5"},{"key":"2025121219273937000_15.6.e096955.5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.51847\/Dfcf6mz3gd","article-title":"Hybrid revascularization in treatment of patients with multilevel vascular lesion of lower extremities of atherosclerotic genesis","volume":"15","author":"Aslanov","year":"2024","journal-title":"Arch Pharm Pract"},{"doi-asserted-by":"publisher","key":"2025121219273937000_15.6.e096955.6","DOI":"10.1016\/j.jvs.2012.01.054"},{"doi-asserted-by":"publisher","key":"2025121219273937000_15.6.e096955.7","DOI":"10.1177\/1526602815592206"},{"key":"2025121219273937000_15.6.e096955.8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1024\/0301-1526\/a000290","article-title":"Early and late outcomes of hybrid endovascular and open repair procedures in patients with peripheral arterial disease","volume":"42","author":"Balaz","year":"2013","journal-title":"Vasa"},{"key":"2025121219273937000_15.6.e096955.9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jvs.2024.03.009","article-title":"Factors associated with 90-day reintervention following lower extremity revascularization","volume":"80","author":"Alabi","year":"2024","journal-title":"J Vasc Surg"},{"key":"2025121219273937000_15.6.e096955.10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.avsg.2020.08.143","article-title":"Comparative Analysis of Outcomes in Patients Undergoing Femoral Endarterectomy plus Endovascular (Hybrid) or Bypass for Femoropopliteal Occlusive Disease","volume":"72","author":"DeCarlo","year":"2021","journal-title":"Ann Vasc Surg"},{"doi-asserted-by":"publisher","key":"2025121219273937000_15.6.e096955.11","DOI":"10.1016\/j.ejvs.2019.05.006"},{"key":"2025121219273937000_15.6.e096955.12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.14797\/mdcj-9-2-90","article-title":"Hybrid interventions in limb salvage","volume":"9","author":"Huynh","year":"2013","journal-title":"Methodist Debakey Cardiovasc J"},{"doi-asserted-by":"publisher","key":"2025121219273937000_15.6.e096955.13","DOI":"10.1017\/S0266462312000086"},{"unstructured":"The EndNote . 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