{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T02:10:05Z","timestamp":1751940605628,"version":"3.41.2"},"reference-count":25,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Medical Research Future Fund 2022 Quality, Safety and Effectiveness of Medicine Use and Medicine Intervention by Pharmacists","award":["MRFMMIP000022"],"award-info":[{"award-number":["MRFMMIP000022"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,6,23]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Most older adults living in residential aged care facilities (RACFs) have at least one marker of potentially suboptimal prescribing. Pharmacists play a crucial role in medication management, with their effectiveness enhanced by using computerised decision support tools. The Pharmacists Review to Optimise Medicines in Residential Aged Care (PROMPT-RC) study aims to optimise medicine use by providing pharmacists in RACFs with an electronic medicine management app with integrated decision support (AusTAPER App\/Pathway) to use as part of medication reviews they undertake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The PROMPT-RC study is a parallel cluster randomised controlled trial design involving Australian RACFs. It will assess if pharmacists\u2019 use of the AusTAPER App\/Pathway for medication reviews improves medication regimens for RACF residents compared with usual care. Pharmacists in RACFs randomised to the intervention arm will be trained to use the AusTAPER App\/Pathway, which flags potentially inappropriate medicines (PIMs) across a person\u2019s entire medicine regimen. Pharmacists in RACFs randomised to the control arm will not have access to the AusTAPER App\/Pathway\u2014they will continue to provide usual care. The primary outcome is the difference in the number of regular medicines between treatment arms at 12 months. Secondary outcomes will measure the number of regular and pro re nata medicines, PIMs, medicine administration times, medicine regimen complexity, use of antipsychotics, antidepressants, and benzodiazepines, quality of life, mortality, instances of physical restraint, and the number of falls, hospitalisations and general practitioner\/health professional visits. The cost-effectiveness of the AusTAPER App\/Pathway compared with usual care will be calculated. Data collection will occur at baseline, 3, 6, 9 and 12 months postrandomisation and 3 and 6\u2009months prebaseline. We aim to recruit 668 participants to adjust for an estimated 10% loss to follow-up, giving 334 participants in each arm. Data analysis will follow an intention-to-treat approach using a linear mixed model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>Ethical approval was obtained from The University of Western Australia Human Research Ethics Committee (Reference: 2024\/ET000525; approved 14 August 2024). Reciprocal approval was also obtained in other states. This study is registered on the Australian New Zealand Clinical Trials Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/anzctr.org.au\">https:\/\/anzctr.org.au<\/jats:ext-link>). Trial findings will be disseminated through national and international peer-reviewed publications and conferences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>ACTRN12624001409561.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-097345","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T01:30:23Z","timestamp":1751938223000},"page":"e097345","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Use of an electronic medication management application to support Pharmacists Review to Optimise Medicines in Residential Aged Care (PROMPT-RC): a study protocol for a parallel cluster randomised controlled trial"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-8469","authenticated-orcid":false,"given":"Amy Theresa","family":"Page","sequence":"first","affiliation":[{"name":"Centre for Optimisation of Medicines, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dee","family":"Mangin","sequence":"additional","affiliation":[{"name":"Public Health and General Practice, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-6943","authenticated-orcid":false,"given":"Hend","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Allied Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa Y H","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety, Monash University, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-4868","authenticated-orcid":false,"given":"Kenneth","family":"Lee","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Allied Health, The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagham","family":"Ailabouni","sequence":"additional","affiliation":[{"name":"The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinta","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-8708","authenticated-orcid":false,"given":"Kathleen","family":"Potter","sequence":"additional","affiliation":[{"name":"Ryman Healthcare, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahal","family":"Mavaddat","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda Marise","family":"Clifford","sequence":"additional","affiliation":[{"name":"Pharmacy, School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elton","family":"Lobo","sequence":"additional","affiliation":[{"name":"The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta","family":"Baldassar","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liza","family":"Seubert","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Petrie","sequence":"additional","affiliation":[{"name":"Centre for Health Economics, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Wang","sequence":"additional","affiliation":[{"name":"RMIT University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hosking","sequence":"additional","affiliation":[{"name":"Deakin University, Burwood, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Tasker","sequence":"additional","affiliation":[{"name":"WA Centre for Health and Ageing, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-0188","authenticated-orcid":false,"given":"Christopher","family":"Etherton-Beer","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia, Crawley, Western Australia, Australia"},{"name":"WA Centre for Health and Ageing, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"2025070718301626000_15.7.e097345.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2010.05.004"},{"key":"2025070718301626000_15.7.e097345.2","doi-asserted-by":"crossref","DOI":"10.1177\/20420986221100117","article-title":"The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative 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