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In addition to motor impairments, ALS frequently involves cognitive and behavioural disturbances, including deficits in social cognition, which can impact interpersonal interactions and decision-making. Despite increasing recognition of these impairments, existing assessment tools often rely on static stimuli, limiting their ecological validity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This cross-sectional, single-centre study aims to assess social cognition abilities in patients with ALS compared with healthy controls using a combination of dynamic and static neuropsychological tools. The primary outcome measure will be performance on the Movie for the Assessment of Social Cognition, an ecologically valid test evaluating theory of mind. Secondary outcomes will include emotion recognition (static and dynamic tasks: Ekman Faces and French Emotion Evaluation Test), mood assessments (Hospital Anxiety and Depression Scale) and clinical variables such as disease severity (ALS Functional Rating Scale-Revised), cognitive function (Edinburgh Cognitive and Behavioural Screen, Mini\u2013Mental State Examination) and disease staging (King\u2019s ALS Clinical Staging System). A total of 74 participants (37 patients with ALS and 37 matched healthy controls) will be recruited. Group differences will be analysed using analysis of variance, while regression models will explore associations between social cognitive deficits and clinical markers of ALS progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved by the French Ethics Committee (CPP) Ouest I under reference 2020-A01213-36. Data collection and processing comply with French and European data protection regulations (GDPR, Loi Informatique et Libert\u00e9s). Findings will be disseminated through peer-reviewed journals and scientific conferences and will contribute to improving neuropsychological assessment methods for ALS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04406675\">NCT04406675<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-097543","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T09:45:35Z","timestamp":1751708735000},"page":"e097543","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of social cognition in patients with amyotrophic lateral sclerosis: protocol for a cross-sectional comparative study at Angers University Hospital"],"prefix":"10.1136","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct04406675","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5822-9049","authenticated-orcid":false,"given":"Juliette","family":"Faure-de Baets","sequence":"first","affiliation":[{"name":"LPPL, Nantes Universit\u00e9, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00e9my","family":"Besnard","sequence":"additional","affiliation":[{"name":"LPPL, Nantes Universit\u00e9, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Cassereau","sequence":"additional","affiliation":[{"name":"CHU d\u2019Angers, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Emmelin","sequence":"additional","affiliation":[{"name":"DEP ENS LLSH Psychologie, Universit\u00e9 Nantes Angers Le Mans, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Allain","sequence":"additional","affiliation":[{"name":"LPPL, Nantes Universit\u00e9, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"key":"2025121222420458000_15.7.e097543.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1603471"},{"key":"2025121222420458000_15.7.e097543.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442207"},{"key":"2025121222420458000_15.7.e097543.3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a024117","article-title":"Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS)","volume":"7","author":"Grad","year":"2017","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025121222420458000_15.7.e097543.4","doi-asserted-by":"publisher","DOI":"10.1080\/146608202760834120"},{"key":"2025121222420458000_15.7.e097543.5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JND-210632","article-title":"Non-Motor Symptoms of Amyotrophic Lateral Sclerosis: A Multi-Faceted Disorder","volume":"8","author":"Nash","year":"2021","journal-title":"J Neuromuscul Dis"},{"key":"2025121222420458000_15.7.e097543.6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.neurol.2022.11.010","article-title":"Retinal vessels as a window on amyotrophic lateral sclerosis pathophysiology: A systematic review","volume":"179","author":"Vautier","year":"2023","journal-title":"Rev Neurol (Paris)"},{"key":"2025121222420458000_15.7.e097543.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307223"},{"key":"2025121222420458000_15.7.e097543.8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3988\/jcn.2016.12.3.295","article-title":"Impaired Perception of Emotional Expression in Amyotrophic Lateral Sclerosis","volume":"12","author":"Oh","year":"2016","journal-title":"J Clin Neurol"},{"key":"2025121222420458000_15.7.e097543.9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300188"},{"key":"2025121222420458000_15.7.e097543.10","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1212\/01.wnl.0000172911.39167.b6","article-title":"Prevalence and patterns of cognitive impairment in sporadic ALS","volume":"65","author":"Ringholz","year":"2005","journal-title":"Neurology (ECronicon)"},{"key":"2025121222420458000_15.7.e097543.11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-444-64150-2.00022-8","article-title":"Social cognition","volume":"173","author":"Beaudoin","year":"2020","journal-title":"Handb Clin Neurol"},{"key":"2025121222420458000_15.7.e097543.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05445.x"},{"key":"2025121222420458000_15.7.e097543.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.08.016"},{"key":"2025121222420458000_15.7.e097543.14","unstructured":"Allain P , Fortier J , Besnard J . 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