{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:04:37Z","timestamp":1787162677037,"version":"build-2736575974"},"reference-count":23,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"unspecified","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the National Key Research and Development Program of China","award":["2023YFC2308701"],"award-info":[{"award-number":["2023YFC2308701"]}]},{"name":"the CAMS Innovation Fund for Medical Sciences","award":["2023-I2M-3-011"],"award-info":[{"award-number":["2023-I2M-3-011"]}]},{"name":"the key discipline of the three-year action plan for strengthening the construction of the public health system in Shanghai","award":["GWVI-11.1-02 Infectious Diseases"],"award-info":[{"award-number":["GWVI-11.1-02 Infectious Diseases"]}]},{"name":"the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences","award":["2021-I2M-1-044"],"award-info":[{"award-number":["2021-I2M-1-044"]}]},{"name":"the Pudong New Area Science and Technology Development Innovation fund","award":["No.PKJ2023-Y73"],"award-info":[{"award-number":["No.PKJ2023-Y73"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,5,14]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We are conducting a longitudinal cohort study\u2014the Community Burden of Acute Respiratory Infections in Shanghai\u2014to assess age-stratified incidence, healthcare utilisation and risk factors of influenza virus, respiratory syncytial virus (RSV) and SARS-CoV-2 associated acute respiratory infections (ARIs) in Shanghai, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Study participants were enrolled by family doctors in all 47 community health services centres in Pudong New Area District, Shanghai, China. All permanent residents 6\u2009months and older living in Pudong for at least 6\u2009months were eligible for enrolment; residents who planned to leave Pudong for more than 1\u2009month in the first study year were excluded. During enrolment, study staff conducted baseline assessments of sociodemographics, underlying medical conditions, vaccination history and household and self-rated health status. Study participants are being followed for ARIs for 3 years. Nasopharyngeal and oropharyngeal swab specimens are being obtained from suspected ARI cases. Influenza virus, RSV, SARS-CoV-2 and other respiratory pathogens are tested for by multiplex respiratory pathogen real-time quantitative PCR assays. Illness courses and clinical recoveries of ARI cases are assessed through weekly contact with ARI cases for 28 days post ascertainment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>Between 14 October 2024 and 22 November 2024, we enrolled 5387 community residents into the cohort, including 233 children aged from 6\u2009months to 2 years, 278 preschool children aged 3\u20136 years, 575 school-age children aged 7\u201318 years, 2150 adults aged 19\u201364 years and 2151 older adults aged 65+years. All finished baseline assessment and started follow-up. Surveillance of ARI symptoms, collection of specimens and laboratory testing are ongoing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>Findings from this study will be used to provide valuable scientific data to inform ongoing control efforts and future pandemic preparedness for respiratory diseases in China. Planned analyses include analysis of annual pathogen-specific incidence by age group and exploration of healthcare seeking behaviour and factors associated with ARIs and severe ARIs. We will also assess transmission dynamics of common respiratory pathogens in a household transmission subcohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-097732","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T14:12:32Z","timestamp":1748527952000},"page":"e097732","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Community burden of acute respiratory infections in Shanghai, a longitudinal cohort study in respiratory pathogens, China, 2024\u20132027"],"prefix":"10.1136","volume":"15","author":[{"given":"Chuchu","family":"Ye","sequence":"first","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai, 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