{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:11:15Z","timestamp":1790698275100,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"unspecified","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,5,12]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the prevalence of diabetes mellitus in patients with Fabry disease using a nationwide population-based dataset. We hypothesised that patients with Fabry disease would have a higher prevalence of diabetes mellitus compared with the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>We identified a study sample from Taiwan\u2019s LHID2010 Database. There were 9408 sampled patients in this study, 2352 study patients with Fabry disease and 7056 propensity-score-matched comparison patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome measures<\/jats:title>\n                    <jats:p>Multiple logistic regression analyses were conducted to explore the association between diabetes mellitus and Fabry disease after taking the variables of age, sex, geographic location, monthly income category, urbanisation level of the patient\u2019s residence, hyperlipidaemia and hypertension into consideration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results revealed significantly higher prevalence of diabetes mellitus among patients with Fabry disease than among comparison patients (35.8% vs 29.6%, p&lt;0.001). The difference was observed, irrespective of gender, males 37.0% vs 30.6%, (p&lt;0.001) and female patients, 34.8% vs 28.7% (p&lt;0.001). The adjusted OR of diabetes mellitus for patients with Fabry disease was 1.424 (95% CI=1.276~1.591) when compared with comparison patients. Classified by sex, the adjusted ORs for diabetes were 1.428 (95% CI=1.213~1.682) for males and 1.424 (95% CI=1.226~1.655) for females. Additionally, among patients aged &lt;65 years, the adjusted OR was 1.489 (95% CI=1.277~1.737), and among patients aged 65 or older, the adjusted OR was 1.361 (95% CI=1.161~1.596).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest the importance of screening for diabetes mellitus in patients with Fabry disease. Physicians should be conscious of this association and be prepared to manage both conditions concurrently.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-099735","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T09:20:23Z","timestamp":1748683223000},"page":"e099735","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["High prevalence of diabetes mellitus among patients with Fabry disease in Taiwan: a cross-sectional study"],"prefix":"10.1136","volume":"15","author":[{"given":"Shih-Han","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Otolaryngology, Wan Fang Hospital, Taipei, Taiwan"},{"name":"International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Xirasagar","sequence":"additional","affiliation":[{"name":"Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Fu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Department of Otorhinolaryngology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-959X","authenticated-orcid":false,"given":"Herng-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan"},{"name":"Research Center of Sleep Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-8171","authenticated-orcid":false,"given":"Chin-Shyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Economics, National Taipei University, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"2025121411561756000_15.5.e099735.1","unstructured":"Desnick R . \u03b1-galactosidase a deficiency fabry disease. In: Desnick RJ , Ioannou YA , Eng CM , et al ., eds. The metabolic and molecular bases of inherit Ed disease. New York: McGraw-Hill, 1995."},{"key":"2025121411561756000_15.5.e099735.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61589-5"},{"key":"2025121411561756000_15.5.e099735.3","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-1"},{"key":"2025121411561756000_15.5.e099735.4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-444-62702-5.00017-2","article-title":"Fabry disease","volume":"132","author":"Schiffmann","year":"2015","journal-title":"Handb Clin Neurol"},{"key":"2025121411561756000_15.5.e099735.5","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-S002"},{"key":"2025121411561756000_15.5.e099735.6","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"2025121411561756000_15.5.e099735.7","doi-asserted-by":"crossref","first-page":"15853","DOI":"10.3390\/ijms242115853","article-title":"Interaction of fabry disease and diabetes mellitus","volume":"24","author":"Kasinath","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025121411561756000_15.5.e099735.8","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2454295","article-title":"Expanded screening for Fabry disease in patients with chronic kidney disease not on dialysis: a multicenter Italian experience","volume":"47","author":"Battaglia","year":"2025","journal-title":"Ren Fail"},{"key":"2025121411561756000_15.5.e099735.9","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800634"},{"key":"2025121411561756000_15.5.e099735.10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF02047896","article-title":"Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus","volume":"18","author":"Kohler","year":"1981","journal-title":"Acta Diabetol Lat"},{"key":"2025121411561756000_15.5.e099735.11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0005-2744(78)90081-5","article-title":"Acid glycohydrolase in Chinese hamster with spontaneous diabetes. 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