{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:47:47Z","timestamp":1767764867099,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Sorocaba"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,12,18]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In chronic kidney disease (CKD), anaemia develops and evolves as kidney dysfunction progresses. The treatment of anaemia is described in clinical practice guidelines (CPGs), which are designed to report the most relevant evidence for clinical practice in disease management. This study will analyse CPGs for transparency, methodological quality and quality of recommendations for their implementation over time, and also compare recommendations for the treatment of anaemia outlined in these documents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>CPGs will be identified by conducting a systematic search of the data sources CINAHL, Embase, MEDLINE, Scielo, Scopus, ProQuest, Trip Database, Virtual Health Library, Web of Science, and guidelines on websites, published between January 2009 and December 2025. Three reviewers will, independently, evaluate the methodological quality of the guidelines using the Appraisal of Guidelines for REsearch and Evaluation II (AGREE-II) tool and the quality of recommendations using the AGREE \u2013 Recommendations Excellence tool. The treatment recommendations for anaemia in CKD will be summarised and compared. Results will be presented in tables and descriptive statistics will be compiled for all domains of the tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This is a literature-based study and, therefore, no ethical approval will be required. Results of the study can be submitted for publication in high-impact, peer-reviewed scientific journals, and also presented at national and international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Prospero registration number<\/jats:title>\n                    <jats:p>CRD42024629656.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-100279","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T05:15:24Z","timestamp":1767762924000},"page":"e100279","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Critical appraisal and comparison of clinical practice guideline recommendations for the treatment of anaemia in chronic kidney disease: a systematic review protocol"],"prefix":"10.1136","volume":"16","author":[{"given":"Jeferson Cesar Moretti","family":"Agnelli","sequence":"first","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanessa Regis da","family":"Costa","sequence":"additional","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Suguimoto","family":"Iwami","sequence":"additional","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginaldo Tavares","family":"Franques","sequence":"additional","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Cruz","family":"Lopes","sequence":"additional","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-3125","authenticated-orcid":false,"given":"Silvio","family":"Barberato-Filho","sequence":"additional","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-1806","authenticated-orcid":false,"given":"Cristiane de C\u00e1ssia","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Science, University of Sorocaba, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"2026010621151243000_16.1.e100279.1","unstructured":"Wang H , Naghavi M , Allen C , et al . Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet 2016;388."},{"key":"2026010621151243000_16.1.e100279.2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz174"},{"key":"2026010621151243000_16.1.e100279.3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)31694-5"},{"key":"2026010621151243000_16.1.e100279.4","unstructured":"US National Institute of Diabetes and Digestive and Kidney Diseases . Kidney disease statistics for the United States. 2023. 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