{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:22:32Z","timestamp":1790796152419,"version":"4.1.0"},"reference-count":34,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K17111"],"award-info":[{"award-number":["20K17111"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,9,30]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship between a quality of life (QOL) score and clinical parameters in patients with hypertrophic cardiomyopathy (HCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A multicentre cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>We analysed data from the Searching for Atrial Fibrillation and Early Recruitment of Heart Failure in HCM registry, collected between 2018 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with HCM (n=499) aged \u226518 years from 12 institutions (Shizuoka Prefecture, Japan) were consecutively enrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>Clinical parameters, along with data from a short form of the Kansas City Cardiomyopathy Questionnaire (KCCQ-12), were collected. The association between each clinical parameter and the KCCQ-12 score was analysed. Clinical parameters with a significant univariable association (p&lt;0.05) were used in a multiple regression model to investigate independent clinical parameters associated with the KCCQ-12 score. The coefficients and relative importance of each parameter included in the multiple regression model were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the univariable analysis, KCCQ-12 scores exhibited significant associations with 21 clinical parameters, including sex, left ventricular morphology and the Pittsburgh Sleep Quality Index (PSQI). The multiple regression model with 12 parameters that had a significant univariable association exhibited an adjusted R\n                      <jats:sup>2<\/jats:sup>\n                      of 0.48. In this model, the PSQI (standardised coefficient \u22120.39; p&lt;0.001), history of sustained ventricular tachycardia or fibrillation, history of atrial fibrillation (\u22120.23; p&lt;0.001), female sex (\u22120.19; p=0.035), systolic blood pressure (0.17; p=0.040), lateral E\/e prime (\u22120.17; p=0.049) and A wave (\u22120.14, p=0.049) were independently associated with the KCCQ-12 score with high relative importance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with HCM, we investigated the association between the KCCQ-12 score and various clinical parameters. PSQI, as well as known heart failure-related clinical parameters, was significantly associated with the KCCQ-12 score. Visualising the associations of various clinical parameters with the KCCQ-12 score will help physicians to consider factors linked to the decline in QOL in patients with HCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-101251","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T06:25:30Z","timestamp":1763101530000},"page":"e101251","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between heart failure-related quality of life and clinical parameters in patients with hypertrophic cardiomyopathy: a cross-sectional analysis of data from a multicentre Japanese registry"],"prefix":"10.1136","volume":"15","author":[{"given":"Masao","family":"Saotome","sequence":"first","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5395-1887","authenticated-orcid":false,"given":"Keitaro","family":"Akita","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"},{"name":"Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Kamakura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Nawada","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiei","family":"Takanaka","sequence":"additional","affiliation":[{"name":"Takanaka Clinic, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hamamatsu Red Cross Hospital, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Tawarahara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hamamatsu Red Cross Hospital, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hamamatsu Medical Center, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Iwata City Hospital, Iwata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shizuoka General Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shizuoka General Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazusa","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, JA Shizuoka Kohseiren Enshu Hospital, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Wakahara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujinomiya City General Hospital, Fujinomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Unno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenori","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terumori","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-7932","authenticated-orcid":false,"given":"Kenichiro","family":"Suwa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-951X","authenticated-orcid":false,"given":"Yoshihisa","family":"Naruse","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2025120413270922000_15.11.e101251.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001250"},{"key":"2025120413270922000_15.11.e101251.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"2025120413270922000_15.11.e101251.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033200"},{"key":"2025120413270922000_15.11.e101251.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.09.011"},{"key":"2025120413270922000_15.11.e101251.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00531-3"},{"key":"2025120413270922000_15.11.e101251.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.001958"},{"key":"2025120413270922000_15.11.e101251.7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jchf.2022.03.002","article-title":"Validation of the Kansas City Cardiomyopathy Questionnaire in Symptomatic Obstructive Hypertrophic Cardiomyopathy","volume":"10","author":"Nassif","year":"2022","journal-title":"JACC Heart Fail"},{"key":"2025120413270922000_15.11.e101251.8","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2023-323856"},{"key":"2025120413270922000_15.11.e101251.9","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"2025120413270922000_15.11.e101251.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00232-8"},{"key":"2025120413270922000_15.11.e101251.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.542"},{"key":"2025120413270922000_15.11.e101251.12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jchf.2021.06.015","article-title":"Health Status Predicts Short- and Long-Term Risk of Composite Clinical Outcomes in Acute Heart Failure","volume":"9","author":"Hu","year":"2021","journal-title":"JACC Heart Fail"},{"key":"2025120413270922000_15.11.e101251.13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1001\/jamacardio.2021.0372","article-title":"Comparison of New York Heart Association Class and Patient-Reported Outcomes for Heart Failure With Reduced Ejection Fraction","volume":"6","author":"Greene","year":"2021","journal-title":"JAMA Cardiol"},{"key":"2025120413270922000_15.11.e101251.14","doi-asserted-by":"publisher","DOI":"10.1253\/circj.66.323"},{"key":"2025120413270922000_15.11.e101251.15","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-016-0467-x","article-title":"Health-related quality of life in hypertrophic cardiomyopathy patients with implantable defibrillators","volume":"14","author":"Magnusson","year":"2016","journal-title":"Health Qual Life Outcomes"},{"key":"2025120413270922000_15.11.e101251.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029267"},{"key":"2025120413270922000_15.11.e101251.17","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012041","article-title":"Impact of Sex on Clinical Course and Survival in the Contemporary Treatment Era for Hypertrophic Cardiomyopathy","volume":"8","author":"Rowin","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2025120413270922000_15.11.e101251.18","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-020-01604-9","article-title":"Quality of life status determinants in hypertrophic cardiomyopathy as evaluated by the Kansas City Cardiomyopathy Questionnaire","volume":"18","author":"Capota","year":"2020","journal-title":"Health Qual Life Outcomes"},{"key":"2025120413270922000_15.11.e101251.19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5664\/jcsm.11040","article-title":"AASM Scoring Manual 3: a step forward for advancing sleep care for patients with obstructive sleep apnea","volume":"20","author":"Malhotra","year":"2024","journal-title":"J Clin Sleep Med"},{"key":"2025120413270922000_15.11.e101251.20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/eurheartj\/ehy838","article-title":"Composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular mortality in older community-dwelling men","volume":"41","author":"Baumert","year":"2020","journal-title":"Eur Heart J"},{"key":"2025120413270922000_15.11.e101251.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.01.009"},{"key":"2025120413270922000_15.11.e101251.22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.5935\/1984-0063.20200104","article-title":"Sensitivity and specificity of four screening sleep-disordered breathing tests in patients with and without cardiovascular disease","volume":"14","author":"Amado-Garz\u00f3n","year":"2021","journal-title":"Sleep Sci"},{"key":"2025120413270922000_15.11.e101251.23","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs054"},{"key":"2025120413270922000_15.11.e101251.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.030"},{"key":"2025120413270922000_15.11.e101251.25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1751-7133.2010.00196.x","article-title":"Incidence of sleep-disordered breathing in patients with hypertrophic cardiomyopathy","volume":"17","author":"Prinz","year":"2011","journal-title":"Congest Heart Fail"},{"key":"2025120413270922000_15.11.e101251.26","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1378\/chest.14-1498","article-title":"Decreased exercise capacity and sleep-disordered breathing in patients with hypertrophic cardiomyopathy","volume":"147","author":"Konecny","year":"2015","journal-title":"Chest"},{"key":"2025120413270922000_15.11.e101251.27","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2335"},{"key":"2025120413270922000_15.11.e101251.28","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.hrthm.2018.12.017","article-title":"Obstructive sleep apnea is associated with nonsustained ventricular tachycardia in patients with hypertrophic obstructive cardiomyopathy","volume":"16","author":"Wang","year":"2019","journal-title":"Heart Rhythm"},{"key":"2025120413270922000_15.11.e101251.29","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-081323","article-title":"Qualitative interview study of patient-reported symptoms, impacts and treatment goals of patients with obstructive hypertrophic cardiomyopathy","volume":"14","author":"Shore","year":"2024","journal-title":"BMJ Open"},{"key":"2025120413270922000_15.11.e101251.30","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.chest.2016.05.004","article-title":"Acute Effects of Nasal CPAP in Patients With Hypertrophic Cardiomyopathy","volume":"150","author":"Nerbass","year":"2016","journal-title":"Chest"},{"key":"2025120413270922000_15.11.e101251.31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015085"},{"key":"2025120413270922000_15.11.e101251.32","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1253\/circj.CJ-18-0575","article-title":"Contemporary Septal Reduction Therapy in Drug-Refractory Hypertrophic Obstructive Cardiomyopathy","volume":"82","author":"Maekawa","year":"2018","journal-title":"Circ J"},{"key":"2025120413270922000_15.11.e101251.33","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1002\/ehf2.14414","article-title":"Effects of bariatric surgery on cardiovascular-related acute care use in patients with hypertrophic cardiomyopathy","volume":"10","author":"Miyashita","year":"2023","journal-title":"ESC Heart Fail"},{"key":"2025120413270922000_15.11.e101251.34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrcardio.2017.6","article-title":"Shared decision-making in HCM","volume":"14","author":"Maron","year":"2017","journal-title":"Nat Rev Cardiol"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-101251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T21:29:04Z","timestamp":1764883744000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-101251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,13]]},"published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1136\/bmjopen-2025-101251"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-101251","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}