{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:07:50Z","timestamp":1776776870387,"version":"3.51.2"},"reference-count":67,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"unspecified","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical Research Future Fund (MRFF) Genomic Health Future Mission","award":["(Application ID: 2025125)"],"award-info":[{"award-number":["(Application ID: 2025125)"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,3,31]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Over the last decade, a growing number of health interventions (eg, medical assistance in dying and mitochondrial donation) have become legalised or decriminalised globally. Newly legalised health interventions share characteristics that are distinct from other health interventions, making their implementation more challenging. They are often highly emotive, controversial and associated with strong opinions and ethical dilemmas, with some of them being high-stake and irreversible. This study aimed to identify, systematise and map the factors that affect the implementation of health interventions that have recently been legalised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A systematically conducted review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>PubMed, Scopus, EMBASE and CINAHL were searched to identify studies published between 2014 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria for selecting studies<\/jats:title>\n                    <jats:p>We included studies if they evaluated the implementation of health interventions that were newly legalised or newly decriminalised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction and synthesis<\/jats:title>\n                    <jats:p>Data were extracted and synthesised through descriptive analysis. Both deductive and inductive thematic analyses were applied to map the barriers, facilitators and implementing strategies that influence the implementation of newly legalised health interventions in healthcare settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search strategy yielded 1510 publications, of which 78 were included in this review. Findings showed that several newly legalised health interventions, including medical assistance in dying (n=56 studies); medical abortion (n=13); assisted human reproduction (n=3); psychedelic-assisted therapies (n=3); use of medical cannabis (n=2) and use of biosimilars (n=1) were addressed. The analysis identified a total of 880 diverse barriers, facilitators and strategies in five domains across system, organisational and individual levels: (1) patients\/service users\/consumers; (2) healthcare providers; (3) healthcare organisation; (4) legal processes and (5) system. These were further divided into 27 themes of barriers, 18 themes of facilitators and 17 themes of strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implementing newly legalised health interventions is complex. Our findings can support the development of an implementation plan for the spread and scaling of future health interventions, maximising the impact of interventions and making them accessible to more people and health organisations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-101271","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:20:20Z","timestamp":1776774020000},"page":"e101271","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["From legalisation to practice: implementation of newly legalised health interventions in healthcare settings \u2013 a systematic review"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-8580","authenticated-orcid":false,"given":"Maryam","family":"Vizheh","sequence":"first","affiliation":[{"name":"Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, School of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-2368","authenticated-orcid":false,"given":"Klay","family":"Lamprell","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, School of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0813-3899","authenticated-orcid":false,"given":"Samran","family":"Sheriff","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, School of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Cormack","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, School of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-4957","authenticated-orcid":false,"given":"Jeffrey","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, School of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karinne","family":"Ludlow","sequence":"additional","affiliation":[{"name":"Faculty of Law, Monash University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Mills","sequence":"additional","affiliation":[{"name":"Monash Bioethics Centre, Monash University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-682X","authenticated-orcid":false,"given":"Janet C","family":"Long","sequence":"additional","affiliation":[{"name":"Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, School of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"2026042105200858000_16.4.e101271.1","doi-asserted-by":"crossref","DOI":"10.1186\/s13012-018-0751-8","article-title":"Criteria for evaluating transferability of health interventions: a systematic review and thematic synthesis","volume":"13","author":"Schloemer","year":"2018","journal-title":"Implement Sci"},{"key":"2026042105200858000_16.4.e101271.2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/jep.13600","article-title":"Too much theory and not enough practice? 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