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Compression therapy has recently gained growing interest as an adjunct to other rehabilitation interventions for managing upper limb dysfunction among stroke survivors. However, the evidence for its effectiveness remains inconsistent and equivocal. Therefore, this systematic review aims to assess the effectiveness of compression therapy in managing upper limb dysfunction in patients with stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic search of databases (PubMed, Scopus, Web of Science, CINAHL, Cochrane Library, Embase, PEDro, OTseeker, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform) will be conducted to identify peer-reviewed studies and relevant grey literature on compression therapy on upper limb dysfunction after stroke. Two reviewers will independently screen, select and extract data, with discrepancies resolved through discussion or involvement of a third reviewer. Outcomes of interest include clinical measures of upper limb function, activity, participation and safety (ie, adverse effects). Risk of bias will be assessed using the Cochrane RoB 2 for randomised studies, the Risk Of Bias In Non-randomised Studies of Interventions for non-randomised studies. The certainty of evidence across types of compression therapy and outcomes will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluation approach. Data will be narratively synthesised, and a meta-analysis will be performed if feasible. The review will be reported following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and will be conducted from September 2025 to December 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This systematic review does not require ethical approval as only secondary data will be used. This review will synthesise the body of evidence on the effectiveness of compression therapy in managing poststroke upper limb dysfunction. Results will then be disseminated through a peer-reviewed publication to inform research and clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42024625815.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-101551","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:25:41Z","timestamp":1759901141000},"page":"e101551","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of compression therapy on the upper limb of patients with stroke: a systematic review protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7851-2374","authenticated-orcid":false,"given":"Jia Min","family":"Lee","sequence":"first","affiliation":[{"name":"Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-5795","authenticated-orcid":false,"given":"Siaw Chui","family":"Chai","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Shi","sequence":"additional","affiliation":[{"name":"Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Beng","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronic & Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Ying","family":"Chu","sequence":"additional","affiliation":[{"name":"Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuicheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Shandong Second Medical University, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Lian","family":"Lim","sequence":"additional","affiliation":[{"name":"Grossman School of Medicine, New York University, New York City, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"2025120415061561000_15.10.e101551.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"2025120415061561000_15.10.e101551.2","doi-asserted-by":"crossref","DOI":"10.1186\/s13561-023-00439-6","article-title":"The costs associated with stroke care continuum: a systematic review","volume":"13","author":"Lucas-Noll","year":"2023","journal-title":"Health Econ Rev"},{"key":"2025120415061561000_15.10.e101551.3","first-page":"1","article-title":"Clinical consequences of stroke","volume":"2016","author":"Robert Teasell","year":"2016","journal-title":"Evidence-Based Review of Stroke Rehabilitation"},{"key":"2025120415061561000_15.10.e101551.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(95)80568-0"},{"key":"2025120415061561000_15.10.e101551.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000238594.91938.1e"},{"key":"2025120415061561000_15.10.e101551.6","unstructured":"Bowen A , James M , Young G , eds. 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