{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:25:48Z","timestamp":1770279948074,"version":"3.49.0"},"reference-count":56,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Central Institute of Mental Health in Mannheim, Germany"},{"DOI":"10.13039\/501100001661","name":"Heidelberg University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001661","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute for Health Research (NIHR) Oxford Cognitive Health Clinical Research Facility","award":["RP-2017-08-ST2-006"],"award-info":[{"award-number":["RP-2017-08-ST2-006"]}]},{"name":"NIHR Oxford and Thames Valley Applied Research Collaboration"},{"name":"NIHR Oxford Health Biomedical Research Centre","award":["NIHR203316"],"award-info":[{"award-number":["NIHR203316"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIHR Oxford Health Biomedical Research Centre","award":["NIHR203316"],"award-info":[{"award-number":["NIHR203316"]}]},{"name":"NIHR Mental Health Translational Research Collaboration (MH-TRC) Mental Health Mission"},{"name":"NIHR Academic Clinical Lectureship"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,9,16]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Major depressive disorder (MDD) is among the most common psychiatric disorders in children and adolescents. While previous meta-analyses have synthesised evidence on the efficacy and acceptability of newer-generation antidepressants in this population, specific adverse events (AEs) remain poorly characterised. This is of high clinical importance, as AEs are burdensome for patients, can reduce treatment adherence and lead to discontinuation. Here, we present a protocol for a network meta-analysis designed to evaluate the specific AE profile and comparative tolerability of newer-generation antidepressants in children and adolescents with MDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The planned study will include double-blind randomised controlled trials that compared one active drug with another and\/or placebo for the acute treatment of MDD in children and adolescents. The following antidepressants will be considered: agomelatine, alaproclate, bupropion, citalopram, desvenlafaxine, duloxetine, edivoxetine, escitalopram, fluoxetine, fluvoxamine, levomilnacipran, milnacipran, mirtazapine, paroxetine, reboxetine, sertraline, venlafaxine, vilazodone and vortioxetine. The primary outcomes will include the number of patients experiencing at least one AE, specific non-serious AEs, serious AEs (eg, suicidal ideation) and AEs leading to treatment discontinuation. Published and unpublished studies will be retrieved through a systematic search in the following databases: PubMed, Embase, Cochrane Library (including the Cochrane Central Register of Controlled Trials), Web of Science Core Collection, PsycInfo and regulatory agencies\u2019 registries. Study selection and data extraction will be performed independently by two reviewers. For each outcome, a network meta-analysis will be performed to synthesise all evidence. Consistency will be assessed through local and global methods, and the confidence in the evidence will be evaluated using the Confidence in Network Meta-Analysis web application. All analyses will be conducted in the R software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The planned review does not require ethical approval. The findings will be published in a peer-reviewed journal and may be presented at international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD420251011399.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-102696","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:26:21Z","timestamp":1759901181000},"page":"e102696","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Side effect profile and comparative tolerability of newer generation antidepressants in the acute treatment of major depressive disorder in children and adolescents: protocol for a systematic review and network meta-analysis"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-612X","authenticated-orcid":false,"given":"Cagdas","family":"T\u00fcrkmen","sequence":"first","affiliation":[{"name":"Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Heidelberg University Medical Faculty Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Sacu","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University Medical Faculty Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1317-0220","authenticated-orcid":false,"given":"Yuki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Technical University of Munich School of Medicine and Health, Munich, Germany"},{"name":"Department of Neuropsychiatry, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angharad N","family":"de Cates","sequence":"additional","affiliation":[{"name":"Institute for Mental Health, University of Birmingham, Birmingham, UK"},{"name":"Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Schoevers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine","family":"Kamphuis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0852-4322","authenticated-orcid":false,"given":"Astrid","family":"Chevance","sequence":"additional","affiliation":[{"name":"INSERM INRAE, Centre for Research in Epidemiology and Statistics, Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Paris, France"},{"name":"AP-HP, H\u00f4pital H\u00f4tel-Dieu Centre d\u2019\u00c9pid\u00e9miologie Clinique, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R","family":"Weisz","sequence":"additional","affiliation":[{"name":"Department of Psychology, Harvard University, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham J","family":"Emslie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA"},{"name":"Children\u2019s Medical Center Dallas, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R","family":"Strawn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E","family":"Hetrick","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orestis","family":"Efthimiou","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland"},{"name":"Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-8508","authenticated-orcid":false,"given":"Georgia","family":"Salanti","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens H","family":"van Dalfsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-3776","authenticated-orcid":false,"given":"Toshi A","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Office of Institutional Advancement and Communications, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-8321","authenticated-orcid":false,"given":"Andrea","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK"},{"name":"NIHR Oxford Health Clinical Research Facility, Warneford Hospital, Oxford Health NHS Foundation Trust, Oxford, UK"},{"name":"Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"2025120415055985000_15.10.e102696.1","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12333"},{"key":"2025120415055985000_15.10.e102696.2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaac.2018.07.896","article-title":"Systematic Review and Meta-Analysis: Adolescent Depression and Long-Term Psychosocial Outcomes","volume":"58","author":"Clayborne","year":"2019","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2025120415055985000_15.10.e102696.3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjment-2023-300707","article-title":"Depressive symptom networks in the UK general adolescent population and in those looked after by local authorities","volume":"26","author":"Schlechter","year":"2023","journal-title":"BMJ Ment Health"},{"key":"2025120415055985000_15.10.e102696.4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjment-2023-300971","article-title":"Psychological well-being and needs of parents and carers of children and young people with mental health difficulties: a quantitative systematic review with meta-analyses","volume":"27","author":"Martin","year":"2024","journal-title":"BMJ Ment Health"},{"key":"2025120415055985000_15.10.e102696.5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjment-2025-301634","article-title":"Advancing the evidence base for child and adolescent psychopharmacology","volume":"28","author":"Cortese","year":"2025","journal-title":"BMJ Ment Health"},{"key":"2025120415055985000_15.10.e102696.6","first-page":"4","article-title":"Update on the Use of SSRIs and SNRIs with Children and Adolescents in Clinical Practice","volume":"25","author":"Jane Garland","year":"2016","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"2025120415055985000_15.10.e102696.7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaac.2022.10.001","article-title":"Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders","volume":"62","author":"Walter","year":"2023","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2025120415055985000_15.10.e102696.8","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30137-1"},{"key":"2025120415055985000_15.10.e102696.9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30385-3"},{"key":"2025120415055985000_15.10.e102696.10","article-title":"New generation antidepressants for depression in children and adolescents: a network meta-analysis","volume":"5","author":"Hetrick","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"2025120415055985000_15.10.e102696.11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/phar.2767","article-title":"Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents","volume":"43","author":"Strawn","year":"2023","journal-title":"Pharmacotherapy"},{"key":"2025120415055985000_15.10.e102696.12","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2880","article-title":"Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration","volume":"339","author":"Stone","year":"2009","journal-title":"BMJ"},{"key":"2025120415055985000_15.10.e102696.13","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.081514"},{"key":"2025120415055985000_15.10.e102696.14","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2019.00294","article-title":"The FDA \u201cBlack Box\u201d Warning on Antidepressant Suicide Risk in Young Adults: More Harm Than Benefits?","volume":"10","author":"Fornaro","year":"2019","journal-title":"Front Psychiatry"},{"key":"2025120415055985000_15.10.e102696.15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/MLR.0000000000000895","article-title":"In Search of a Pony: Sources, Methods, Outcomes, and Motivated Reasoning","volume":"56","author":"Stone","year":"2018","journal-title":"Med Care"},{"key":"2025120415055985000_15.10.e102696.16","doi-asserted-by":"crossref","unstructured":"T\u00fcrkmen C , Machunze N , Lee AM , et al . Systematic Review and Meta-Analysis: The Association Between Newer-Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder. J Am Acad Child Adolesc Psychiatry 2025. doi:10.1016\/j.jaac.2025.01.006","DOI":"10.1016\/j.jaac.2025.01.006"},{"key":"2025120415055985000_15.10.e102696.17","doi-asserted-by":"crossref","DOI":"10.1136\/bmjment-2024-301162","article-title":"Comparing apples and oranges in youth depression treatments? A quantitative critique of the evidence base and guidelines","volume":"28","author":"Stringaris","year":"2025","journal-title":"BMJ Ment Health"},{"key":"2025120415055985000_15.10.e102696.18","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"2025120415055985000_15.10.e102696.19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"2025120415055985000_15.10.e102696.20","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300087"},{"key":"2025120415055985000_15.10.e102696.21","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jaac.2020.07.905","article-title":"Core Outcome Set Development for Adolescent Major Depressive Disorder Clinical Trials: A Registered Report","volume":"59","author":"Monga","year":"2020","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2025120415055985000_15.10.e102696.22","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1136\/ebmental-2021-300418","article-title":"Important adverse events to be evaluated in antidepressant trials and meta-analyses in depression: a large international preference study including patients and healthcare professionals","volume":"25","author":"Chevance","year":"2022","journal-title":"Evid Based Ment Health"},{"key":"2025120415055985000_15.10.e102696.23","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"2025120415055985000_15.10.e102696.24","unstructured":"EndNote [program]. Clarivate; 2023."},{"key":"2025120415055985000_15.10.e102696.25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002127","article-title":"Reporting of Adverse Events in Published and Unpublished Studies of Health Care Interventions: A Systematic Review","volume":"13","author":"Golder","year":"2016","journal-title":"PLoS Med"},{"key":"2025120415055985000_15.10.e102696.26","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h4320","article-title":"Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence","volume":"351","author":"Le Noury","year":"2015","journal-title":"BMJ"},{"key":"2025120415055985000_15.10.e102696.27","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.12"},{"key":"2025120415055985000_15.10.e102696.28","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"MANTEL","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"2025120415055985000_15.10.e102696.29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/eb-2018-102911","article-title":"Practical guide to the meta-analysis of rare events","volume":"21","author":"Efthimiou","year":"2018","journal-title":"Evid Based Ment Health"},{"key":"2025120415055985000_15.10.e102696.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.02.012"},{"key":"2025120415055985000_15.10.e102696.31","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1230"},{"key":"2025120415055985000_15.10.e102696.32","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010247","article-title":"Plea for routinely presenting prediction intervals in meta-analysis","volume":"6","author":"IntHout","year":"2016","journal-title":"BMJ Open"},{"key":"2025120415055985000_15.10.e102696.33","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1195"},{"key":"2025120415055985000_15.10.e102696.34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/eb-2015-102088","article-title":"A primer on network meta-analysis with emphasis on mental health","volume":"18","author":"Mavridis","year":"2015","journal-title":"Evid Based Ment Health"},{"key":"2025120415055985000_15.10.e102696.35","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-2-201307160-00008"},{"key":"2025120415055985000_15.10.e102696.36","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1037"},{"key":"2025120415055985000_15.10.e102696.37","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8158"},{"key":"2025120415055985000_15.10.e102696.38","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1002\/sim.9562","article-title":"Network meta-analysis of rare events using penalized likelihood regression","volume":"41","author":"Evrenoglou","year":"2022","journal-title":"Stat Med"},{"key":"2025120415055985000_15.10.e102696.39","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1044"},{"key":"2025120415055985000_15.10.e102696.40","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3767"},{"key":"2025120415055985000_15.10.e102696.41","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","article-title":"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis","volume":"391","author":"Cipriani","year":"2018","journal-title":"The Lancet"},{"key":"2025120415055985000_15.10.e102696.42","doi-asserted-by":"crossref","first-page":"e1232","DOI":"10.1038\/tp.2017.203","article-title":"Outcome reporting bias in randomized-controlled trials investigating antipsychotic drugs","volume":"7","author":"Lancee","year":"2017","journal-title":"Transl Psychiatry"},{"key":"2025120415055985000_15.10.e102696.43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002101","article-title":"Assessment of Adverse Events in Protocols, Clinical Study Reports, and Published Papers of Trials of Orlistat: A Document Analysis","volume":"13","author":"Schroll","year":"2016","journal-title":"PLoS Med"},{"key":"2025120415055985000_15.10.e102696.44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa065779"},{"key":"2025120415055985000_15.10.e102696.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2025.111677"},{"key":"2025120415055985000_15.10.e102696.46","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-021-02166-3","article-title":"ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis","volume":"19","author":"Chiocchia","year":"2021","journal-title":"BMC Med"},{"key":"2025120415055985000_15.10.e102696.47","doi-asserted-by":"crossref","DOI":"10.1186\/s12874-023-02038-9","article-title":"Semi-automated assessment of the risk of bias due to missing evidence in network meta-analysis: a guidance paper for the ROB-MEN web-application","volume":"23","author":"Chiocchia","year":"2023","journal-title":"BMC Med Res Methodol"},{"key":"2025120415055985000_15.10.e102696.48","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076754","article-title":"ROB-ME: a tool for assessing risk of bias due to missing evidence in systematic reviews with meta-analysis","volume":"383","author":"Page","year":"2023","journal-title":"BMJ"},{"key":"2025120415055985000_15.10.e102696.49","doi-asserted-by":"crossref","unstructured":"Schwarzer G . meta: An R package for meta-analysis, 7.2007:40\u20135.","DOI":"10.32614\/CRAN.package.meta"},{"key":"2025120415055985000_15.10.e102696.50","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v106.i02","article-title":"netmeta: An R Package for Network Meta-Analysis Using Frequentist Methods","volume":"106","author":"Balduzzi","year":"2023","journal-title":"J Stat Softw"},{"key":"2025120415055985000_15.10.e102696.51","doi-asserted-by":"crossref","DOI":"10.1186\/s12874-023-02130-0","article-title":"crossnma: An R package to synthesize cross-design evidence and cross-format data using network meta-analysis and network meta-regression","volume":"24","author":"Hamza","year":"2024","journal-title":"BMC Med Res Methodol"},{"key":"2025120415055985000_15.10.e102696.52","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"2025120415055985000_15.10.e102696.53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099682","article-title":"Evaluating the quality of evidence from a network meta-analysis","volume":"9","author":"Salanti","year":"2014","journal-title":"PLoS One"},{"key":"2025120415055985000_15.10.e102696.54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003082","article-title":"CINeMA: An approach for assessing confidence in the results of a network meta-analysis","volume":"17","author":"Nikolakopoulou","year":"2020","journal-title":"PLoS Med"},{"key":"2025120415055985000_15.10.e102696.55","doi-asserted-by":"crossref","DOI":"10.1002\/cl2.1080","article-title":"CINeMA: Software for semiautomated assessment of the confidence in the results of network meta-analysis","volume":"16","author":"Papakonstantinou","year":"2020","journal-title":"Campbell Syst Rev"},{"key":"2025120415055985000_15.10.e102696.56","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.332"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-102696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:08:04Z","timestamp":1764889684000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-102696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,7]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1136\/bmjopen-2025-102696"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-102696","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}