{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:57:14Z","timestamp":1787860634366,"version":"build-2784847793"},"reference-count":58,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Canada Research Chairs (HKB, AG, TG, JAH)"],"award-info":[{"award-number":["Canada Research Chairs (HKB, AG, TG, JAH)"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","award":["#2425-HQ-000099"],"award-info":[{"award-number":["#2425-HQ-000099"]}],"id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,7,31]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Opioids are widely used during pregnancy and can lead to health complications for pregnant people, parents and their children. Yet, little is known about the long- and short-term effects of perinatal opioid exposures on health outcomes in Canada. Evidence is needed to inform optimal support for maternal and child health following perinatal opioid exposures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We aim to develop the Canadian Perinatal Opioid Project, a pan-Canadian federated health data system to capture perinatal opioid exposures across multiple provinces, along with subsequent maternal and child health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This health data system uses population-based administrative health records from Alberta, British Columbia, Manitoba, Ontario and Saskatchewan, each with two population-based cohorts: (1) all pregnancies among people aged 12\u201349 years, 2013\u20132023 and (2) liveborn infants from these pregnancies. Pregnant people will be followed for 1\u2009year after the end of pregnancy; live births will be followed for 8 years. Data will be obtained from outpatient prescription opioid records, mother-infant linked hospitalisation records, emergency department visits, outpatient physician visits, birth registries and vital statistics. This work is being conducted in collaboration with Indigenous and non-Indigenous people with lived\/living experience of perinatal opioid use and knowledge users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Analysis<\/jats:title>\n                    <jats:p>We will use descriptive statistics to describe incidence and cohort characteristics and Poisson regression to assess annual trends. Patient-level analysis will occur in each province, and province-level aggregated results will be meta-analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval was granted by research ethics boards at the University of British Columbia (H24-03406), University of Calgary (REB24-1721), University of Manitoba (HS26640), University of Toronto (46764) and University of Saskatchewan (5348). We will develop knowledge dissemination plans and products with people with lived\/living experience of perinatal opioid use and knowledge users. Health data indicators will be featured in an open-access online dashboard. We expect to share methods and research findings through peer-reviewed publications in high-impact journals, presentations at national and international conferences, presentations to community members and knowledge users, and research summaries for the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-103160","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T19:15:21Z","timestamp":1756667721000},"page":"e103160","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Canadian perinatal opioid project: a protocol for a national health data system"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-8856","authenticated-orcid":false,"given":"Andi","family":"Camden","sequence":"first","affiliation":[{"name":"Edwin SH Leong Centre for Healthy Children, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary K","family":"Brown","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Department of Health and Society, University of Toronto at Scarborough, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Gomes","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Hutcheon","sequence":"additional","affiliation":[{"name":"Healthy Starts, British Columbia Children\u2019s Hospital Research Institute, Vancouver, British Columbia, Canada"},{"name":"Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Children\u2019s Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Edwin SH Leong Centre for Healthy Children, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-5421","authenticated-orcid":false,"given":"Nazeem","family":"Muhajarine","sequence":"additional","affiliation":[{"name":"Department of Community Health and Epidemiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"},{"name":"Saskatchewan Population Health and Evaluation Research Unit (SPHERU), Saskatoon, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan C","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Manitoba Inuit Association, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel","family":"Sharpe","sequence":"additional","affiliation":[{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-2253","authenticated-orcid":false,"given":"Astrid","family":"Guttmann","sequence":"additional","affiliation":[{"name":"Edwin SH Leong Centre for Healthy Children, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"ICES, Toronto, Ontario, Canada"},{"name":"Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"2025123106482612000_15.8.e103160.1","unstructured":"Federal, provincial, and territorial Special Advisory Committee on the Epidemic of Opioid Overdoses . 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