{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:09:18Z","timestamp":1764889758062,"version":"3.46.0"},"reference-count":41,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"French National Platform for End-of-Life Research"},{"DOI":"10.13039\/501100015721","name":"Caisse nationale de solidarit\u00e9 pour l\u2019autonomie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,9,8]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Informal caregivers play a vital role in caring for individuals who choose to spend the end of their life at home. However, this caregiving role often imposes considerable physical, emotional, social and financial burdens that can negatively impact caregivers\u2019 quality of life. A comprehensive understanding of the breadth of interventions designed to support caregivers of individuals receiving home-based palliative and end-of-life care is essential, along with insights into how these interventions are perceived by those who have received them. The objective of this review is to synthesise existing evidence on the effectiveness and appropriateness of interventions that support informal caregivers of patients receiving home-based palliative care in order to address the caregivers\u2019 needs and improve their quality of life. Additionally, this review aims to explore the acceptability and perceived benefits of these interventions from the perspectives of informal caregivers who have received them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A comprehensive search will be performed in the following databases: MEDLINE (PubMed), CINAHL, PsycINFO, Web of Science, Scopus, Cairn.info, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL). This review will include studies that focus on adult informal caregivers of adult patients with serious life-threatening illnesses receiving home-based palliative care. Interventional studies that employed quantitative, qualitative and mixed-methods approaches will be considered. Quantitative studies will include randomised controlled trials (RCTs) and experimental and quasi-experimental designs. Qualitative studies will encompass research that explores informal caregivers\u2019 experiences with the interventions, perceived benefits and barriers and enablers influencing intervention effectiveness. Mixed-methods studies using convergent, embedded or sequential designs will also be included.<\/jats:p>\n                    <jats:p>The search will include studies published in English or French, with no restrictions on the publication period. Study selection, critical appraisal and data extraction will be conducted independently by two reviewers to ensure methodological rigour. This review will adhere to the Joanna Briggs Institute guidelines for mixed-methods systematic reviews, using a convergent segregated approach. Findings will be reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical review is not required for this study, as it is a literature review that does not involve the collection of primary data. The findings of this review will be disseminated to the scientific community through conference presentations and peer-reviewed publications. Additionally, lay summaries will be prepared and shared with the general public and relevant stakeholders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration Number<\/jats:title>\n                    <jats:p>PROSPERO, registration number CRD420251006612.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-103705","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T05:55:33Z","timestamp":1759470933000},"page":"e103705","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and appropriateness of interventions to enhance the quality of life of informal caregivers of patients receiving home-based palliative care: a mixed-methods systematic review protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4153-8742","authenticated-orcid":false,"given":"Benoite","family":"Umubyeyi","sequence":"first","affiliation":[{"name":"D\u00e9partement Recherche Enseignement Formation, Maison M\u00e9dicale Jeanne Garnier, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-3696","authenticated-orcid":false,"given":"Emilie","family":"Allard","sequence":"additional","affiliation":[{"name":"Facult\u00e9 des Sciences Infirmi\u00e8res, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-318X","authenticated-orcid":false,"given":"Johanna","family":"De Almeida Mello","sequence":"additional","affiliation":[{"name":"LUCAS - Center for Care Research and Consultancy, KU Leuven, Leuven, Belgium"},{"name":"Department of Oral Health Sciences, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7523-6933","authenticated-orcid":false,"given":"Sophie","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"D\u00e9partement Recherche Enseignement Formation, Maison M\u00e9dicale Jeanne Garnier, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-1681","authenticated-orcid":false,"given":"Isabelle","family":"Vedel","sequence":"additional","affiliation":[{"name":"Family Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2201-5487","authenticated-orcid":false,"given":"Emmanuel","family":"Bagaragaza","sequence":"additional","affiliation":[{"name":"D\u00e9partement Recherche Enseignement Formation, Maison M\u00e9dicale Jeanne Garnier, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"2025120415050914000_15.10.e103705.1","unstructured":"International Alliance of Carer Organizations . 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