{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:14:59Z","timestamp":1785190499127,"version":"3.55.0"},"reference-count":39,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fisher & Paykel"},{"name":"Orkyn"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,8,19]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Sickle cell disease (SCD) is due to the mutation of haemoglobin (Hb), from HbA to HbS and characterised by recurrent vaso-occlusive crises (VOC), which can progress to acute chest syndrome (ACS), a leading cause of death in adults with SCD. Hypoxia is a key modifiable factor in the polymerisation of HbS and the pathogenesis of VOC. High-flow nasal oxygen (HFNO) delivers humidified gas at high oxygen concentrations and flow rates: the former may reverse sickling (metabolic effect) to accelerate VOC resolution and prevent ACS, while the latter may reduce the risk of ACS by mitigating hypercapnia and generating positive airway pressure that limits hypoventilation and atelectasis (pulmonary effect). The study hypothesises that HFNO is a safe and effective strategy for treating VOC and preventing secondary ACS, and will assess this using a multi-arm multi-stage (MAMS) trial design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>This is a prospective, multicentre, randomised, open-label controlled trial following an MAMS design with three phases and four arms: one control (low-flow oxygen) and three HFNO intervention arms with varying fraction of inspired oxygen levels (low, intermediate, high). The pilot stage will assess safety and feasibility, using the rate of cardiac and neurological events as the primary endpoint. In the activity stage, arms demonstrating acceptable safety will be compared for efficacy based on the rate of VOC resolution without complications by day 5, allowing selection of the most promising arm. The final efficacy stage will compare the selected HFNO strategy to control, with prevention of secondary ACS by day 14 as the primary endpoint. The study aims to enrol up to 350 VOC episodes in total.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The study has been granted ethical approval (CPP SUD MEDITERRANEE IV). Following the provision of informed consent, patients will be included in the study. The results will be submitted for publication in peer-reviewed journals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03976180\">NCT03976180<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-104564","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T03:16:48Z","timestamp":1758165408000},"page":"e104564","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["High flow oxygen for vaso-occlusive crisis: a multicentre, prospective, randomised, multi-arm, multi-stage clinical trial (OSONE)"],"prefix":"10.1136","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct03976180","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-5577","authenticated-orcid":false,"given":"Armand","family":"Mekontso Dessap","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pitaux Universitaires Henri-Mondor, AP-HP, Cr\u00e9teil, France"},{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris Est Cr\u00e9teil (UPEC), Institut Mondor de Recherche Biom\u00e9dicale (IMRB), INSERM U955, Cr\u00e9teil, France"},{"name":"INSERM U955, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoosha","family":"Habibi","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Maladies G\u00e9n\u00e9tiques du Globule Rouge, H\u00f4pitaux Universitaires Henri Mondor, AP-HP, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Guillaud","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Aval des Urgences, H\u00f4pitaux Universitaires Henri Mondor, AP-HP, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kassasseya","sequence":"additional","affiliation":[{"name":"Service d\u2019Acceuil des Urgences, AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Larrat","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Bretonneau, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3768-3496","authenticated-orcid":false,"given":"Ma\u00eft\u00e9","family":"Agbakou","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tona","family":"Tchoubou","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Delafontaine, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Candille","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, CHU Grenoble Alpes, Grenoble, Auvergne-Rh\u00f4ne-Alpes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Clinique, H\u00f4pital Saint Vincent de Paul, Groupe Hospitalier de l\u2019Institut Catholique de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-4013","authenticated-orcid":false,"given":"Mickael","family":"Landais","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation m\u00e9dico-chirurgicale et unit\u00e9 de soins continus, Centre Hospitalier Le Mans, Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Beno\u00eet","family":"Arlet","sequence":"additional","affiliation":[{"name":"French National reference center for sickle cell disease, Department of Internal Medicine, European Georges Pompidou Hospital, AP-HP, Paris-Cit\u00e9 University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Fartoukh","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris Est Cr\u00e9teil (UPEC), Institut Mondor de Recherche Biom\u00e9dicale (IMRB), INSERM U955, Cr\u00e9teil, France"},{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Tenon, AP-HP, Sorbonne Universit\u00e9, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Desclaux","sequence":"additional","affiliation":[{"name":"Service des Maladies infectieuses et tropicales, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Masseau","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Oziel","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation m\u00e9dico-chirurgicale, H\u00f4pital Avicenne, APHP, Universit\u00e9 Sorbonne Paris Nord, Bobigny, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihem","family":"Bouharaoua","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Institut Universitaire du Cancer de Toulouse (IUCT) Oncopole, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Comlan","family":"Affo","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Louis-Mourier, AP-HP, Colombes, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Viglino","sequence":"additional","affiliation":[{"name":"Service des Urgences adultes Nord, CHU Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latifatou","family":"Boukari","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Saint-Antoine, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Ensenyat","family":"Martin","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine intensive R\u00e9animation, CH Sud Francilien, Corbeil-Essonnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Ngo","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CH Saint-Denis, Saint-Denis, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Anguel","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Bic\u00eatre, AP-HP, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Chantalat","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne - Immunologie, H\u00f4pital Bic\u00eatre, AP-HP, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bourgarit-Durand","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Jean-Verdier, AP-HP, Bondy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Genty","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre Hospitalier Intercommunal de Cr\u00e9teil, Cr\u00e9teil, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Makowski","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Guillet","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires Henri Mondor, AP-HP, Cr\u00e9teil, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Melica","sequence":"additional","affiliation":[{"name":"Service d\u2019Immunologie Clinique et Maladies Infectieuses, H\u00f4pitaux Universitaires Henri Mondor, AP-HP, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lionnet","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Tenon, AP-HP, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Le Jeune","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Avicenne, AP-HP, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Joseph","sequence":"additional","affiliation":[{"name":"D\u00e9partement de bioth\u00e9rapie, H\u00f4pital Necker-Enfants Malades, AP-HP, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[{"name":"Service des Maladies infectieuses et tropicales adultes, H\u00f4pital Necker-Enfants Malades, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Cougoul","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU de Toulouse, Institut Universitaire du Cancer de Toulouse (IUCT) Oncopole, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bertchansky","sequence":"additional","affiliation":[{"name":"Reference Centre for Rare Red Blood Cell Disorders, CHU de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonnick","family":"Boue","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, CH Mayotte, Mayotte, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Bartolucci","sequence":"additional","affiliation":[{"name":"INSERM U955, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"},{"name":"Unit\u00e9 des Maladies G\u00e9n\u00e9tiques du Globule Rouge, H\u00f4pitaux Universitaires Henri Mondor, AP-HP, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9gol\u00e8ne","family":"Gendreau","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pitaux Universitaires Henri-Mondor, AP-HP, Cr\u00e9teil, France"},{"name":"Groupe de Recherche Clinique CARMAS, Universit\u00e9 Paris Est Cr\u00e9teil (UPEC), Institut Mondor de Recherche Biom\u00e9dicale (IMRB), INSERM U955, Cr\u00e9teil, France"},{"name":"INSERM U955, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Audureau","sequence":"additional","affiliation":[{"name":"Service de Sant\u00e9 Publique, Unit\u00e9 de Recherche Clinique, H\u00f4pitaux Universitaires Henri Mondor, AP-HP, Cr\u00e9teil, France"},{"name":"Equipe Clinical Epidemiology and Ageing (CEpiA), IMRB, INSERM U955, Universit\u00e9 Paris Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"2025091720152533000_15.9.e104564.1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02437-2","article-title":"Nationwide retrospective study of critically ill adults with sickle cell disease in France","volume":"11","author":"Agbakou","year":"2021","journal-title":"Sci Rep"},{"key":"2025091720152533000_15.9.e104564.2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajh.21569","article-title":"Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease","volume":"85","author":"Fitzhugh","year":"2010","journal-title":"American J Hematol"},{"key":"2025091720152533000_15.9.e104564.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509143331104"},{"key":"2025091720152533000_15.9.e104564.4","doi-asserted-by":"crossref","first-page":"5S3","DOI":"10.1016\/S0248-8663(15)60002-9","article-title":"Recommandations fran\u00e7aises de prise en charge de la dr\u00e9panocytose de l\u2019adulte : actualisation 2015","volume":"36","author":"Habibi","year":"2015","journal-title":"La Revue de M\u00e9decine Interne"},{"key":"2025091720152533000_15.9.e104564.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10517"},{"key":"2025091720152533000_15.9.e104564.6","article-title":"Letter: Hyperbaric oxygen therapy for refractory osseous painful attacks in homozygous drepanocytosis","volume":"4","author":"Coeur","year":"1975","journal-title":"Nouv Presse Med"},{"key":"2025091720152533000_15.9.e104564.7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.0954-6820.1949.tb09554.x","article-title":"Sickle Cell Anemia Treated by Oxygen Tent","volume":"134","author":"Godfried","year":"1949","journal-title":"Journal of Internal Medicine"},{"key":"2025091720152533000_15.9.e104564.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1971.03180380035007"},{"key":"2025091720152533000_15.9.e104564.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503326"},{"key":"2025091720152533000_15.9.e104564.10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ebiom.2016.06.038","article-title":"Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients","volume":"10","author":"Bartolucci","year":"2016","journal-title":"EBioMedicine"},{"key":"2025091720152533000_15.9.e104564.11","doi-asserted-by":"crossref","first-page":"5S3","DOI":"10.1016\/S0248-8663(15)60002-9","article-title":"French guidelines for the management of adult sickle cell disease: 2015 update","volume":"36","author":"Habibi","year":"2015","journal-title":"Rev Med Interne"},{"key":"2025091720152533000_15.9.e104564.12","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-025-01479-3","article-title":"Guidelines for the management of emergencies and critical illness in pediatric and adult patients with sickle cell disease","volume":"15","author":"Mekontso Dessap","year":"2025","journal-title":"Ann Intensive Care"},{"key":"2025091720152533000_15.9.e104564.13","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-024-01367-2","article-title":"Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference","volume":"14","author":"Helms","year":"2024","journal-title":"Ann Intensive Care"},{"key":"2025091720152533000_15.9.e104564.14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2871"},{"key":"2025091720152533000_15.9.e104564.15","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-015-0084-6"},{"key":"2025091720152533000_15.9.e104564.16","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780080407"},{"key":"2025091720152533000_15.9.e104564.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"2025091720152533000_15.9.e104564.18","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200112000-00013"},{"key":"2025091720152533000_15.9.e104564.19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-227330"},{"key":"2025091720152533000_15.9.e104564.20","unstructured":"Bartolucci P , Habibi A , Khellaf M , et al . A monocentric, prospective, observational study on vaso-occlusive crisis (voc) in adult sickle-cell disease (scd). characteristics and predictive score of secondary acute chest syndrome (presev study). 18th Congress of the European Hematology Association; 2013:408."},{"key":"2025091720152533000_15.9.e104564.21","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4202"},{"key":"2025091720152533000_15.9.e104564.22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.csda.2010.10.027","article-title":"An R package for implementing simulations for seamless phase II\/III clinical trials using early outcomes for treatment selection","volume":"56","author":"Parsons","year":"2012","journal-title":"Computational Statistics & Data Analysis"},{"key":"2025091720152533000_15.9.e104564.23","unstructured":"Parsons N . Asd: simulations for adaptive seamless designs. 2013."},{"key":"2025091720152533000_15.9.e104564.24","doi-asserted-by":"crossref","DOI":"10.1186\/s12874-015-0082-2","article-title":"A re-randomisation design for clinical trials","volume":"15","author":"Kahan","year":"2015","journal-title":"BMC Med Res Methodol"},{"key":"2025091720152533000_15.9.e104564.25","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-016-1736-z","article-title":"Using re-randomization to increase the recruitment rate in clinical trials - an assessment of three clinical areas","volume":"17","author":"Kahan","year":"2016","journal-title":"Trials"},{"key":"2025091720152533000_15.9.e104564.26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011276","article-title":"SWIM (sickle with ibuprofen and morphine) randomised controlled trial fails to recruit: lessons learnt","volume":"6","author":"Cho","year":"2016","journal-title":"BMJ Open"},{"key":"2025091720152533000_15.9.e104564.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.1999.01286.x"},{"key":"2025091720152533000_15.9.e104564.28","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990730)18:14<1833::AID-SIM221>3.0.CO;2-3"},{"key":"2025091720152533000_15.9.e104564.29","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3436"},{"key":"2025091720152533000_15.9.e104564.30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101539"},{"key":"2025091720152533000_15.9.e104564.31","doi-asserted-by":"crossref","unstructured":"Mathieu D , Mehdaoui H . Sickle cell disease. In: Handbook on Hyperbaric Medicine Springer Netherlands. 2006: 577\u201384.","DOI":"10.1007\/1-4020-4448-8_33"},{"key":"2025091720152533000_15.9.e104564.32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1971.03180380035007"},{"key":"2025091720152533000_15.9.e104564.33","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199208000-00007"},{"key":"2025091720152533000_15.9.e104564.34","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI102221","article-title":"The role of oxygen in the regulation of erythropoiesis; depression of the rate of delivery of new red cells to the blood by high concentrations of inspired oxygen","volume":"28","author":"TINSLEY","year":"1949","journal-title":"J Clin Invest"},{"key":"2025091720152533000_15.9.e104564.35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408023110504"},{"key":"2025091720152533000_15.9.e104564.36","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V86.10.3998.bloodjournal86103998","article-title":"Oxygen inhalation in nonhypoxic sickle cell patients during vaso-occlusive crisis","volume":"86","author":"Khoury","year":"1995","journal-title":"Blood"},{"key":"2025091720152533000_15.9.e104564.37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201402-0364OC"},{"key":"2025091720152533000_15.9.e104564.38","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01681"},{"key":"2025091720152533000_15.9.e104564.39","first-page":"1344","article-title":"Comparison of three high flow oxygen therapy delivery devices: a clinical physiological cross-over study","volume":"79","author":"Chanques","year":"2013","journal-title":"Minerva Anestesiol"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-104564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T03:17:04Z","timestamp":1758165424000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-104564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,17]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1136\/bmjopen-2025-104564"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-104564","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}