{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:07:28Z","timestamp":1782140848842,"version":"3.54.5"},"reference-count":46,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"unspecified","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,10,10]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was aimed to evaluate the association between the atherogenic index of plasma (AIP) and long-term major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study utilised data from two tertiary care centres in China, which were retrospectively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>This retrospective cohort study initially enrolled 953 adult (\u226518 years) patients with acute STEMI undergoing PCI. After applying exclusion criteria (including prior myocardial infarction, severe hepatic\/renal dysfunction, lost follow-up and so on), 784 participants with complete clinical data comprised the final cohort and were divided into three AIP groups based on tertiles of AIP levels: low AIP group (n=260), medium AIP group (n=261) and high AIP group (n=263).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High AIP patients exhibited significantly higher 2-year MACEs rates versus lower tertiles (p&lt;0.05). After adjusting for age, sex, smoking and other factors, high AIP remained an independent MACEs predictor (OR:2.44; 95%\u2009CI 1.55 to 3.84; p&lt;0.001). After adjustment, each one-unit increment in the AIP was associated with an adjusted OR of 3.295 (95% CI 1.683 to 6.449; p=0.001) for MACEs. In subgroup analyses, the high AIP level was a risk factor for the development of MACEs in patients of all ages, males, smokers, non-diabetic group and high low-density lipoprotein cholesterol group (p&lt;0.05). Restricted cubic spline analysis showed a linear association between AIP levels and MACEs (p overall &lt;0.05, p non-linear &gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates the AIP independently predicts 2-year MACEs in STEMI patients post-PCI, particularly recurrent acute coronary syndrome, suggesting its utility as a cost-effective prognostic tool complementary to traditional lipid metrics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-104635","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:52:12Z","timestamp":1763628732000},"page":"e104635","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association between the atherogenic index of plasma and long-term prognosis in acute ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention: a retrospective cohort study"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4161-1683","authenticated-orcid":false,"given":"Yiwen","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Phase I Clinical Trial Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The Sixth People\u2019s Hospital of Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of General Practice, The 13th People\u2019s Hospital of Chongqing, 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