{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:01:33Z","timestamp":1764478893794,"version":"3.46.0"},"reference-count":25,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"unspecified","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032579","name":"Beijing Medical Award Foundation","doi-asserted-by":"crossref","award":["24H1187"],"award-info":[{"award-number":["24H1187"]}],"id":[{"id":"10.13039\/100032579","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Postdoctoral Fellowship Program of CPS Funder Grant","award":["GZC20231830"],"award-info":[{"award-number":["GZC20231830"]}]},{"name":"Clinical Research Finding of Chinese Society of Cardiovascular Disease (CSC) of 2019","award":["No. HFCSC2019B01"],"award-info":[{"award-number":["No. HFCSC2019B01"]}]},{"name":"Sichuan Science and Technology Program","award":["2024NSFSC0652","2023NSFSC1715","2024YFFK0257","2024YFFK0258","2025ZNSFSC1767","2025ZNSFSC1772","23ZDYF2519"],"award-info":[{"award-number":["2024NSFSC0652","2023NSFSC1715","2024YFFK0257","2024YFFK0258","2025ZNSFSC1767","2025ZNSFSC1772","23ZDYF2519"]}]},{"name":"Sichuan University Interdisciplinary Innovation Fund"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271981","82120108015","82302168","82304078","82402249","82402250","82402251","82471970","824B2052"],"award-info":[{"award-number":["82271981","82120108015","82302168","82304078","82402249","82402250","82402251","82471970","824B2052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,11,7]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Coronary artery involvement remains the primary focus in the long-term management of Kawasaki disease (KD). However, previous studies suggest that myocardial abnormalities frequently persist beyond coronary artery involvement in KD patients. Yet, their temporal evolution and clinical implications remain poorly characterised. To address this gap, we established the Kawasaki disease cardiac imaging (KDCI) cohort, integrating cardiac magnetic resonance (CMR) with echocardiography, coronary CT angiography (CCTA) and invasive angiography. These multimodal imaging approaches enable comprehensive assessment of cardiac abnormalities and elucidate the role of cardiac imaging in optimising long-term KD management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The KDCI cohort is a prospective study aiming to enrol 400\u2013500 KD patients diagnosed at West China Second University Hospital from September 2018 to September 2035. To date, 207 participants have been recruited. Participants will perform the multimodal cardiac imaging including echocardiography, CMR, CCTA, invasive angiography and comprehensive laboratory testing under a scheduled protocol in the follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>The KDCI cohort has established baseline characteristics for 207 KD patients. Of those included to date, 72.0% (149\/207) received intravenous immunoglobulin (IVIG) treatment, with 26.1% (54\/207) demonstrating IVIG resistance, and 37.7% (78\/207) exhibiting coronary artery dilatation. Longitudinal follow-up data are available for 80.7% (167\/207) of participants, with a median follow-up duration of 2.7 years and a follow-up patient-years of 594 patient-years. Of the 207 patients, 16.9% (35\/207) patients experienced endpoint events, encompassing coronary artery thrombosis (8.2%, 17\/207), coronary stenosis\/obstruction (5.3% 11\/207) and clinical myocardial infarction (1.9%, 4\/207). Based on the data collected, we have demonstrated the cardiac abnormalities beyond coronary artery involvement in KD by CMR and CCTA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plan<\/jats:title>\n                    <jats:p>The KDCI cohort will maintain ongoing recruitment and longitudinal follow-up, with a projected enrolment exceeding 400 participants by 2035. This expansion will yield a median follow-up duration of 10 years, providing robust long-term outcome data. We have implemented standardised protocols for scheduled follow-up assessments and data collection in newly enrolled patients. Furthermore, planned genomic analyses will be incorporated to investigate the molecular pathogenesis and prognostic determinants of KD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-104945","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:00:22Z","timestamp":1764478822000},"page":"e104945","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical impact of multimodal cardiac imaging in Kawasaki disease: a prospective Kawasaki disease cardiac imaging (KDCI) cohort study with follow-up data in a Chinese population"],"prefix":"10.1136","volume":"15","author":[{"given":"Yaoji","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University West China Second University Hospital, Chengdu, Sichuan, 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University Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrui","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengkun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"},{"name":"Department of Radiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-9887","authenticated-orcid":false,"given":"Ying-kun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-7520","authenticated-orcid":false,"given":"Yue","family":"Ma","sequence":"additional","affiliation":[{"name":"West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-1319","authenticated-orcid":false,"given":"Ling-yi","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University West China Second University Hospital, Chengdu, Sichuan, 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