{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:16:59Z","timestamp":1758190619576,"version":"3.44.0"},"reference-count":51,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"French Ministry of Health","award":["PHRIP DGOS 2022- Number: PHRIP-22-0028"],"award-info":[{"award-number":["PHRIP DGOS 2022- Number: PHRIP-22-0028"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,8,29]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) is an intensive rehabilitation programme for children with cerebral palsy (CP) delivered in a day camp setting recognised to promote the acquisition of specific functional abilities and independence. Currently, during HABIT-ILE camps, families are minimally involved in their child\u2019s motor learning processes. This explains the challenges reported by both families and therapists, including difficulties in reinforcing skills at home, limited transfer to other functional goals and a lack of confidence in parents\u2019 adaptive competence (self-determination and empowerment). Increasing family involvement in intensive motor rehabilitation programmes and the child\u2019s developmental process by reinforcing skills at home could help reduce the parental impact of the child\u2019s disability, enhance family satisfaction and strengthen their resources to support their child\u2019s daily learning during and after the camp.<\/jats:p>\n                  <jats:p>To address this, we developed the PARTNER programme, which combines HABIT-ILE with a structured home component focused on parent coaching.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>We designed a non-inferiority, mixed-methods, multicentre randomised controlled trial to compare the efficacy at 3 months of the PARTNER programme (35\u2009hours HABIT-ILE+15\u2009hours home programme) with the standard HABIT-ILE programme (50\u2009hours) on the bimanual performance (Assisting Hand Assessment) of children with unilateral CP aged 3\u20135 years. The secondary aims are to compare the 3-month efficacy of the programmes on occupational performance, functional skills and upper limb activity levels, as well as families\u2019 resources, the parent\u2013child relationship, the quantity and quality of resources available in the home to stimulate the child\u2019s motor development, and parental perceptions of their child\u2019s disability and their child\u2019s abilities (qualitative study). The tertiary aim is to conduct a cost-effectiveness analysis of care consumption in each group up to 6 months after the end of the programmes.<\/jats:p>\n                  <jats:p>Target recruitment is 66 children (33 in each group) from 3 centres in France. Outcomes will be evaluated before the interventions, immediately after, at 3 months and up to 6 months for the cost-effectiveness analysis. Families in the PARTNER group will receive specific coaching and extensive support to perform the home programme. The coaching will focus on enhancing their resources.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The study protocol has been reviewed, and ethics approval obtained from the Protection of Persons Committee (PPC) (PPC number: 2024-A01051-46). The results from this study will be actively disseminated through manuscript publications and conference presentations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06963151\">NCT06963151<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-105076","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:25:51Z","timestamp":1758090351000},"page":"e105076","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Is PARTNER, a hybrid HABIT-ILE programme with parent coaching, as effective as standard HABIT-ILE in children with cerebral palsy aged 3\u20135? A protocol for a multicentre, randomised controlled trial"],"prefix":"10.1136","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct06963151","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06963151","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Josselin","family":"Demas","sequence":"first","affiliation":[{"name":"Angers University Hospital, Angers, France"},{"name":"Centre Hospitalier de Laval Institut de Formation en Masso-Kinesitherapie, Laval, France"},{"name":"Les Capucins Readaptation Specialisee et Soins de Longue Duree, Angers, France"},{"name":"Universit\u00e9 d\u2019Angers Laboratoire Angevin de Recherche en Ing\u00e9nierie des Syst\u00e8mes, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Jacquemot","sequence":"additional","affiliation":[{"name":"Service de MPR p\u00e9diatrique L\u2019Escale, Hospices Civils de Lyon, Lyon, France"},{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290, Universit\u00e9 Claude Bernard, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Paediatric Rehabilitation Department, Fondation Ildys, Brest, France"},{"name":"INSERM UMR1101, Brest, France"},{"name":"CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam Le","family":"Goff","sequence":"additional","affiliation":[{"name":"IMT Atlantique, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Carcreff","sequence":"additional","affiliation":[{"name":"Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickael","family":"Dinomais","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Physique et de R\u00e9adaptions, CHU Angers-Capucins, Angers, France"},{"name":"Laboratoire Angevin de Recherche en Ing\u00e9nierie des Syst\u00e8mes, Universit\u00e9 d\u2019Angers, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Vuillerot","sequence":"additional","affiliation":[{"name":"Service de MPR p\u00e9diatrique L\u2019Escale, Hospices Civils de Lyon, Lyon, France"},{"name":"Institute NeuroMyoG\u00e8ne, Lyon, France"},{"name":"INSERM U1315, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Brochard","sequence":"additional","affiliation":[{"name":"INSERM UMR1101, Brest, France"},{"name":"CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Dubois","sequence":"additional","affiliation":[{"name":"Cognition, Behaviour, Communication (LP3C), Laboratoire de psychologie, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-5495","authenticated-orcid":false,"given":"Rodolphe","family":"Bailly","sequence":"additional","affiliation":[{"name":"Paediatric Rehabilitation Department, Fondation Ildys, Brest, France"},{"name":"INSERM UMR1101, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"2025091623252960000_15.9.e105076.1","unstructured":"H.A.S. 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