{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:58Z","timestamp":1787017078166,"version":"build-2736575974"},"reference-count":31,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"unspecified","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,3,16]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify cross-registrations (ie, registrations of the same trial in different registries) among clinical trials affiliated with German University Medical Centres (UMCs) and to describe how these cross-registrations are linked. To determine the consistency of key information across registrations of the same trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Registry-based study of clinical trials affiliated with German UMCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>2895 interventional trials affiliated with German UMCs, registered on ClinicalTrials.gov or the German Clinical Trials Register (DRKS) and completed between 2009 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Number of potential cross-registrations involving the EU Clinical Trials Register (EUCTR) and the type of linkage between these cross-registrations. In a manually validated subset, consistency across registry entries of the same trial was assessed for prospective registration, recruitment status, completion date and availability of summary results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 625 potential EUCTR cross-registrations. The majority of potential cross-registrations (n=470; 75%) were linked through a trial registration number (TRN) in at least one of the registries. Only 109 (17%) were linked through a TRN in both registries. Title matching and TRNs in trial results publications led to an additional 155 (25%) potential cross-registrations. In a sample of 228 manually confirmed EUCTR cross-registrations, 85% (95% CI 80% to 89%; n=189) had the same overall recruitment status while 50% (95% CI 43% to 57%; n=92) had the same completion date across registrations of the same trial. EUCTR was the dominant route for summary results availability and included structured tabular results as well as other formats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among trials affiliated with German UMCs, cross-registrations are common, yet often inadequately linked and present discrepant information. In Germany, where registration in multiple registries is common, cross-registrations can meaningfully influence assessments of trial registration and results reporting and therefore warrant explicit consideration in transparency monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-105173","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:30:18Z","timestamp":1777386618000},"page":"e105173","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Accounting for cross-registration in monitoring transparency in clinical trials: a cross-sectional study of trials at German university medical centres"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-9247","authenticated-orcid":false,"given":"Luciano","family":"Fernandez","sequence":"first","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0473-8504","authenticated-orcid":false,"given":"Elisa","family":"Bascunan Atria","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-383X","authenticated-orcid":false,"given":"Samruddhi Suresh","family":"Yerunkar","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-9504","authenticated-orcid":false,"given":"Maia","family":"Salholz-Hillel","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-6153","authenticated-orcid":false,"given":"Vladislav","family":"Nachev","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-3608","authenticated-orcid":false,"given":"Susanne Gabriele","family":"Schorr","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-079X","authenticated-orcid":false,"given":"Daniel","family":"Strech","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-9115","authenticated-orcid":false,"given":"Delwen L","family":"Franzen","sequence":"additional","affiliation":[{"name":"QUEST Center for Responsible Research, Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2026042807300485000_16.4.e105173.1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0140-6736(13)62228-X","article-title":"Reducing waste from incomplete or unusable reports of biomedical research","volume":"383","author":"Glasziou","year":"2014","journal-title":"The Lancet"},{"key":"2026042807300485000_16.4.e105173.2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718001873"},{"key":"2026042807300485000_16.4.e105173.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.12.012"},{"key":"2026042807300485000_16.4.e105173.4","article-title":"Time to publication for results of clinical trials","volume":"11","author":"Showell","year":"2024","journal-title":"Cochrane Database Syst Rev"},{"key":"2026042807300485000_16.4.e105173.5","doi-asserted-by":"crossref","first-page":"111710","DOI":"10.1016\/j.jclinepi.2025.111710","article-title":"Results reporting for clinical trials led by medical universities and university hospitals in the nordic countries was often missing or delayed","volume":"181","author":"Nilsonne","year":"2025","journal-title":"J Clin Epidemiol"},{"key":"2026042807300485000_16.4.e105173.6","unstructured":"World Health Organization . 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