{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:23Z","timestamp":1787016983418,"version":"build-2736575974"},"reference-count":58,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"unspecified","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Monash Partners"},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1170847"],"award-info":[{"award-number":["APP1170847"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Australian Department of Health and Wellbeing"},{"DOI":"10.13039\/100012737","name":"Department of Health, State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,8,21]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Women with gestational diabetes mellitus (GDM) are at seven-fold to ten-fold increased risk of type 2 diabetes mellitus (T2DM) when compared with those who experience a normoglycaemic pregnancy, and the cumulative incidence increases with the time of follow-up post birth. This protocol outlines the development and validation of a risk prediction model assessing the 5-year and 10-year risk of T2DM in women with a prior GDM diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Data from all birth mothers and registered births in Victoria and South Australia, retrospectively linked to national diabetes data and pathology laboratory data from 2008 to 2021, will be used for model development and validation of GDM to T2DM conversion. Candidate predictors will be selected considering existing literature, clinical significance and statistical association, including age, body mass index, parity, ethnicity, history of recurrent GDM, family history of T2DM and antenatal and postnatal glucose levels. Traditional statistical methods and machine learning algorithms will explore the best-performing and easily applicable prediction models. We will consider bootstrapping or K-fold cross-validation for internal model validation. If computationally difficult due to the expected large sample size, we will consider developing the model using 80% of available data and evaluating using a 20% random subset. We will consider external or temporal validation of the prediction model based on the availability of data. The prediction model\u2019s performance will be assessed by using discrimination (area under the receiver operating characteristic curve, calibration (calibration slope, calibration intercept, calibration-in-the-large and observed-to-expected ratio), model overall fit (Brier score and Cox-Snell R2) and net benefit (decision curve analysis). To examine algorithm equity, the model\u2019s predictive performance across ethnic groups and parity will be analysed. Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis-Artificial Intelligence (TRIPOD+AI) statements will be followed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approvals have been received from Deakin University Human Research Ethics Committee (2021\u2013179); Monash Health Human Research Ethics Committee (RES-22-0000-048A); the Australian Institute of Health and Welfare (EO2022\/5\/1369); the Aboriginal Health Research Ethics Committee of South Australia (SA) (04-23-1056); in addition to a Site-Specific Assessment to cover the involvement of the Preventative Health SA (formerly Wellbeing SA) (2023\/SSA00065). Project findings will be disseminated in peer-reviewed journals and at scientific conferences and provided to relevant stakeholders to enable the translation of research findings into population health programmes and health policy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-106052","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:25:19Z","timestamp":1757913919000},"page":"e106052","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Developing and validating a risk prediction model for conversion to type 2 diabetes mellitus in women with a history of gestational diabetes mellitus: protocol for a population-based, data-linkage study"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8514-1763","authenticated-orcid":false,"given":"Vincent","family":"Versace","sequence":"first","affiliation":[{"name":"Deakin Rural Health, School of Medicine, Deakin University, Warrnambool, Victoria, Australia"},{"name":"Geohealth Laboratory, Department of Population Health, Dasman Diabetes Institute, Kuwait City, Al Asimah Governate, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Boyle","sequence":"additional","affiliation":[{"name":"Health & Biomedical Research Information Technology Unit (HaBIC R2), Department of General Practice and Primary Care, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Janus","sequence":"additional","affiliation":[{"name":"Western Health Chronic Disease Alliance and Department of Medicine, Western Health\u2014Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia"},{"name":"Deakin University, School of Medicine, Warrnambool Campus, Warrnambool, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Deakin Rural Health, School of Medicine, Deakin University, Warrnambool, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-7312","authenticated-orcid":false,"given":"Tesfaye R","family":"Feyissa","sequence":"additional","affiliation":[{"name":"Deakin Rural Health, School of Medicine, Deakin University, Warrnambool, Victoria, Australia"},{"name":"Geohealth Laboratory, Department of Population Health, Dasman Diabetes Institute, Kuwait City, Al Asimah Governate, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8984-1495","authenticated-orcid":false,"given":"Yitayeh","family":"Belsti","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and 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