{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:40:21Z","timestamp":1767796821312,"version":"3.49.0"},"reference-count":41,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Science, Research and Cultural Affairs of the State of Brandenburg"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,11,14]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Research Domain Criteria (RDoC) approach initiated by the National Institute of Mental Health provides a comprehensive framework for guiding research on mental illness and health. Since retrospective studies have indicated associations between RDoC characteristics and clinically relevant as well as care-relevant outcomes, there is a need for prospective, theory-driven investigations that systematically link a priori defined assessments of RDoC constructs to clinically and care-relevant outcomes in a transdiagnostic psychiatric sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This prospective observational study assesses six domains\u2014Positive Valence Systems, Negative Valence Systems, Cognitive Systems, Social Processes, Arousal and Regulatory Systems and Sensorimotor Systems\u2014employing a comprehensive set of self-report and additional paradigms to assess cognitive functioning developed a priori in alignment with the RDoC framework while also assessing clinically and care-relevant variables (eg, length of hospital stay). A total of 300 adult participants will be recruited among in- and outpatients of two psychiatric hospitals in Germany (patient group) as well as from the general population (healthy control group). Including healthy individuals will allow for the investigation of continuous variations in psychological functioning rather than categorical distinctions between health and disease. Data collection includes self-reports, clinician ratings, file review and behavioural assessments. Electroencephalography is recorded in a subgroup of participants. A confirmatory factor analysis will be conducted to reproduce the factor structure and regression models will be used to investigate associations between RDoC domains and clinically relevant as well as care-related variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval was obtained from the local ethics committee of the Brandenburg Medical School\u2014Theodor Fontane (E-01-20220822). Results will be disseminated through peer-reviewed journals and academic conferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-106149","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:25:36Z","timestamp":1765369536000},"page":"e106149","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol for a prospective observational study linking research domain criteria-based phenotypes with clinical and care-related outcomes in psychiatric patients and healthy controls: the VeRDoC study"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-7327","authenticated-orcid":false,"given":"Kristin","family":"Koller-Schlaud","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Meixner","sequence":"additional","affiliation":[{"name":"Center for Aging Research, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany"},{"name":"Department of Psychology, Brandenburg Medical School, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Psychology, Brandenburg Medical School, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"Waghals","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Rentzsch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-9108","authenticated-orcid":false,"given":"Bernd R","family":"F\u00f6rstner","sequence":"additional","affiliation":[{"name":"Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Potsdam, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin\/Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Heinze","sequence":"additional","affiliation":[{"name":"Center for Mental Health, Center for Mental Health, Immanuel Clinic R\u00fcdersdorf, Brandenburg Medical School, R\u00fcdersdorf bei Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Behr","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School, Neuruppin, Germany"},{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-966X","authenticated-orcid":false,"given":"Michael","family":"Rapp","sequence":"additional","affiliation":[{"name":"Social and Preventive Medicine, Department of Sports and Health Sciences, University of Potsdam, Potsdam, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin\/Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Tschorn","sequence":"additional","affiliation":[{"name":"Social and Preventive Medicine, Department of Sports and Health Sciences, 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