{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:18:57Z","timestamp":1764890337689,"version":"3.46.0"},"reference-count":28,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,10,2]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Platelet and fresh frozen plasma (FFP) transfusions are routinely employed in the management of severe dengue. Previous research has indicated a potential link between ABO blood groups and susceptibility to dengue, with evidence suggesting that mosquito vector feeding preferences may be influenced by host blood type. These factors could potentially impact transfusion demands during outbreaks. This retrospective study aimed to investigate the relationship between ABO blood groups and transfusion requirements in patients with dengue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was conducted at a tertiary care hospital in Kerala.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and laboratory data were reviewed for 199 patients confirmed with dengue who received blood component transfusions and compared with two control groups: 200 randomly selected patients with dengue who did not require transfusions and 200 patients without dengue who required transfusions, over a period spanning January 2015 to March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among transfused dengue cases, blood groups O (41.71%), A (28.14%) and B (23.12%) were most prevalent; however, no statistically significant association was observed between ABO blood group and transfusion requirement. Furthermore, the total volumes of FFP and platelet transfusions did not differ significantly across ABO groups among patients with dengue. Notably, platelet transfusions were significantly more frequent in dengue cases (92.0%) compared with transfused patients without dengue (35.5%), whereas FFP transfusions were more common in non-dengue transfused cases (84.5%) than in patients with dengue (44.7%). Patients with dengue also received significantly higher mean volumes of both FFP and platelets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite earlier reports linking ABO blood types to dengue susceptibility, this study found no significant association with transfusion requirements, warranting confirmation through larger multicentre studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-106287","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:56:14Z","timestamp":1761209774000},"page":"e106287","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association between ABO blood group and blood component transfusion requirements in dengue infection: a retrospective study from a tertiary hospital in Kerala, India"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3969-5596","authenticated-orcid":false,"given":"Cleetus","family":"Cherupanakkal","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"},{"name":"Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupa","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0298-5363","authenticated-orcid":false,"given":"Jeby Jose","family":"Olickal","sequence":"additional","affiliation":[{"name":"Department of Public Health, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jabiya Eliza","family":"Varughese","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ani","family":"Thampi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali Anne","family":"Jacob","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"},{"name":"Department of Microbiology, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riju","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri","family":"Jayaprasad","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisha Elsa","family":"Varghese","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Believers Church Medical College Hospital, Thiruvalla, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2025120415080774000_15.10.e106287.1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5501\/wjv.v4.i2.113","article-title":"Is transfusion-transmitted dengue fever a potential public health threat?","volume":"4","author":"Pozzetto","year":"2015","journal-title":"World J Virol"},{"key":"2025120415080774000_15.10.e106287.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1348(03)00004-2"},{"key":"2025120415080774000_15.10.e106287.3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.9734\/ajrid\/2023\/v14i1279","article-title":"Dengue Fever: Etiology, Diagnosis, Prevention and Treatment","volume":"14","author":"Nyenke","year":"2023","journal-title":"AJRID"},{"key":"2025120415080774000_15.10.e106287.4","doi-asserted-by":"crossref","unstructured":"Behera B , Rout B, RajashreePanigrahy , et al . 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