{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:19:20Z","timestamp":1764890360155,"version":"3.46.0"},"reference-count":103,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007537","name":"Freie Universit\u00e4t Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heigl-Stiftung"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,9,23]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mental disorders are among the leading causes of the global burden of disease and are often associated with severe functional impairment and high societal costs. Psychotherapeutic, psychopharmacological and internet-based mental health interventions have proven to be helpful, but challenges remain, including only moderate response rates, high relapse rates and barriers to accessing mental healthcare. Much of the existing evidence stems from studies conducted in controlled, often standardised settings that only partially reflect real-world conditions, contributing to a \u2018scientist-practitioner gap\u2019. Moreover, the mechanisms of change, such as the interaction between treatment intensity, common factors (eg, the therapeutic relationship) and specific intervention techniques, have not been sufficiently investigated. In particular, the relationship of changes in personality functioning (PF) with mental and physical health has not yet been extensively researched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The PSYMPACT (Psychological Impact Factors of Mental Health Treatments) study will use a longitudinal study design with a naturalistic sample (N \u2248 3000) to examine changes in psychopathology, PF and allostatic load in psychotherapeutic, psychopharmacological and internet-based treatments. The aim is to identify factors contributing to improvements and deteriorations in mental and physical health across different settings, including common and specific factors. Additionally, to provide patient perspectives, qualitative interviews will be conducted with individuals with varying levels of severity of mental health problems. Allostatic load will be assessed using repeated hair cortisol measurements. Furthermore, ecological momentary assessment will be used to examine the diurnal variability of PF as well as its more momentary correlates and longer-term outcomes. The central research questions and aims include (1) the assessment of common factors across different treatment settings, (2) associations of specific and common factors with improvements in mental health, including PF, (3 and 4) the importance of treatment intensity and interaction effects with common and specific factors, (5) the association of changes in psychopathology with changes in allostatic load, (6) the trait and state variability of PF, (7) the identification of patients who deteriorate under specific treatments and (8) patients\u2019 perspectives on the effectiveness of different treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Approval was obtained from the Ethics Committee of the Department of Education and Psychology at the Freie Universit\u00e4t Berlin, Germany. Results will be submitted to peer-reviewed specialised journals and presented at national and international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration details<\/jats:title>\n                    <jats:p>\n                      Before data collection started in November 2024, the study was registered in the German Clinical Trials Register (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.drks.de\/search\/de\/trial\/DRKS00035560\">https:\/\/www.drks.de\/search\/de\/trial\/DRKS00035560<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-106741","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:00:52Z","timestamp":1761033652000},"page":"e106741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of change in naturalistic mental health care settings: study protocol for a longitudinal multimethod study"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1830-7682","authenticated-orcid":false,"given":"Phileas","family":"Heim","sequence":"first","affiliation":[{"name":"Division of Clinical-Psychological Intervention, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin-Potsdam, Berlin\/Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Brose","sequence":"additional","affiliation":[{"name":"Division of Clinical-Psychological Intervention, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin-Potsdam, Berlin\/Potsdam, Germany"},{"name":"Department of Psychology, Faculty of Health and Sports, HMU Health and Medical University, Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"B\u00f6ttche","sequence":"additional","affiliation":[{"name":"Division of Clinical-Psychological Intervention, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin-Potsdam, Berlin\/Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M J","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Psychoneuroimmunology Laboratory, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"},{"name":"Charit\u00e9 Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9 - 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