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Profile membership associations were assessed using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests, univariate analysis and multivariable logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frailty status of patients can be divided into three different categories: (1) robust group (23.0%), (2) prefrail group (49.6%) and (3) frail group (27.4%). Frailty demonstrated independent associations with nine clinical parameters in adjusted regression models: radiotherapy session frequency, social support, age, CCI score, educational attainment, metastasis, nutritional risk, radiation-induced injuries and serum albumin levels (p&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The distinct frailty profiles identified by LPA can inform the future development of targeted care protocols for specific subgroups (eg, the frail group), with a focus on key predictors such as age and nutritional risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-108357","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:25:34Z","timestamp":1770967534000},"page":"e108357","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Latent profiles of frailty in patients with head and neck cancer undergoing radiotherapy: a cross-sectional study"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-9275","authenticated-orcid":false,"given":"Xiaolan","family":"Pu","sequence":"first","affiliation":[{"name":"School of Nursing, Southwest Medical University, Luzhou, Sichuan, China"},{"name":"The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Ju","sequence":"additional","affiliation":[{"name":"School of Nursing, Southwest Medical University, Luzhou, Sichuan, China"},{"name":"The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingping","family":"Han","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiong","family":"Ma","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Vocational and Technical College, Suining, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing, Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"2026021223251236000_16.2.e108357.1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"2026021223251236000_16.2.e108357.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.08.008"},{"key":"2026021223251236000_16.2.e108357.3","doi-asserted-by":"crossref","unstructured":"Sharma S , Kumar Upadhyay A , Prakash A , et al . 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