{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:20:26Z","timestamp":1764890426758,"version":"3.46.0"},"reference-count":43,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"unspecified","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,10,10]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) affects 1 in 10 people worldwide and can progress towards kidney failure, which is best predicted by the severity of kidney fibrosis. Currently, kidney fibrosis can only be detected by invasive kidney biopsy which carries procedural risks with limitations on repeat testing. MRI techniques have emerged as potential surrogate markers for kidney fibrosis, though data remain limited. To date, no studies have examined postgadolinium contrast T1 mapping in kidney fibrosis despite its proven utility in assessing myocardial fibrosis. This study aims to develop a multiparametric MRI biomarker including postcontrast imaging to quantify kidney fibrosis in individuals with CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>In this observational cohort study, a control group of 20 healthy adult volunteers will establish healthy kidney MRI parameters. Two adult non-dialysis CKD cohorts (each n=24) who have undergone kidney biopsy within the last month will derive and validate the MRI models, respectively. Tubulointerstitial fibrosis on kidney biopsy will be assessed by Masson trichrome staining and quantified based on the percentage of cortex affected by blinded pathologists. All participants will undergo a single multiparametric kidney MRI including kidney volumetry, T1 mapping (pre-low-dose and post-low-dose contrast), T2 mapping, T2* mapping, diffusion weighted imaging and phase-contrast MRI of renal artery flow. The primary outcome will be the association between a composite multiparametric MRI marker and tubulointerstitial fibrosis with a minimum variance of 50%. The association between the multiparametric MRI marker and individual MRI variables, and tubulointerstitial fibrosis, estimated glomerular filtration rate and albuminuria will also be studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval has been obtained by the Northern Sydney Local Health District Human Research Ethics Committee (2022\/ETH00972). Results will be disseminated in relevant peer-reviewed journals and presented at academic conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12622000855729p (Pre-results).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-108747","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:27:52Z","timestamp":1761758872000},"page":"e108747","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Invasive Magnetic resonance imaging Biomarkers to evaLuatE histology-proven kidney fibrosis in Chronic Kidney Disease (NIMBLE-CKD): an observational cohort study protocol"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-5770","authenticated-orcid":false,"given":"Dana","family":"Kim","sequence":"first","affiliation":[{"name":"The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6437-5018","authenticated-orcid":false,"given":"Rebecca","family":"Kozor","sequence":"additional","affiliation":[{"name":"The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia"},{"name":"Department of Cardiology, Royal North Shore Hospital, St Leonards, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7575-9877","authenticated-orcid":false,"given":"Muh Geot","family":"Wong","sequence":"additional","affiliation":[{"name":"The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia"},{"name":"Department of Renal Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-2038","authenticated-orcid":false,"given":"Martin","family":"Ugander","sequence":"additional","affiliation":[{"name":"The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia"},{"name":"Department of Clinical Physiology, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2025120415090847000_15.10.e108747.1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158765","article-title":"Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PLoS One"},{"key":"2025120415090847000_15.10.e108747.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"2025120415090847000_15.10.e108747.3","unstructured":"International Society of Nephrology . 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