{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:09:05Z","timestamp":1789193345493,"version":"build-2803163510"},"reference-count":34,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Ottawa Department of Family Medicine Program for Research and Innovation in Primary Care and Medical Education","award":["20-939502000"],"award-info":[{"award-number":["20-939502000"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,8,8]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and internally validate a clinical prediction model estimating the probability of emergency caesarean delivery among low-risk pregnancies using routinely available intrapartum variables. The model is intended to support clinicians in recommending transfer decisions in rural obstetric settings without onsite caesarean capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study with multivariable logistic regression and internal validation using bootstrap resampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Province-wide birth registry in Ontario, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Singleton, hospital births from low-risk pregnancies between 1 April 2012 and 31 March 2020, captured in the Better Outcomes Registry and Network Ontario. Exclusions included previous caesarean, major comorbidities and other high-risk conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>Emergency caesarean delivery during labour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 611 644 low-risk pregnancies, 66 482 (10.9%) resulted in emergency caesarean delivery. Key predictors included abnormal fetal health surveillance, nulliparity, gestational hypertension, polyhydramnios area under the receiver operating characteristic curve (AUC) and oxytocin augmentation. The optimism-corrected AUC was 0.86, indicating strong discrimination. Calibration was generally good, though the model underestimated caesarean risk in patients first admitted to level I hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents a proof-of-concept prototype with strong discrimination, though calibration of the full model was suboptimal in level I hospitals, the intended setting for application. While not clinically deployable in its current form, the model lays the groundwork for a translational pathway that will require local recalibration, external validation and contextual adaptation before implementation. Threshold-based clinical utility (eg, positive\/negative predictive value or net benefit) was not assessed and will be evaluated during external validation and local recalibration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-110073","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:15:24Z","timestamp":1789190124000},"page":"e110073","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Development and internal validation of an intrapartum caesarean risk prediction model to guide rural obstetric transfer decisions: a population-based study using BORN Ontario data"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-8609","authenticated-orcid":false,"given":"Kheira","family":"Jolin-Dahel","sequence":"first","affiliation":[{"name":"Department of Family Medicine, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Family Medicine, Winchester District Memorial Hospital, Winchester, Hampshire, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Hawken","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Bruce","sequence":"additional","affiliation":[{"name":"Better Outcomes Registry and Network (BORN) Ontario, Ottawa, Ontario, Canada"},{"name":"Children\u2019s Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"2026091122151348000_16.9.e110073.1","unstructured":"Canadian Institute for Health Information (CIHI) . Hospital births in Canada: a focus on women living in rural and remote areas. 2013. Available: https:\/\/publications.gc.ca\/collections\/collection_2013\/icis-cihi\/H118-89-2013-eng.pdf [Accessed 2 Jun 2025]."},{"key":"2026091122151348000_16.9.e110073.2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12913-015-1034-6","article-title":"The safety of Canadian rural maternity services: a multi-jurisdictional cohort analysis","volume":"15","author":"Grzybowski","year":"2015","journal-title":"BMC Health Serv Res"},{"key":"2026091122151348000_16.9.e110073.3","unstructured":"Association of Ontario Midwives . Rural and remote maternity care in Ontario: analysis and recommendations. 2015. Available: https:\/\/www.ontariomidwives.ca\/sites\/default\/files\/Rural%20and%20Remote%20Maternity%20Care%20in%20Ontario%20Analysis%20and%20Recommendations%20FINAL.pdf [Accessed 3 Jun 2025]."},{"key":"2026091122151348000_16.9.e110073.4","doi-asserted-by":"crossref","first-page":"e558","DOI":"10.1016\/j.jogc.2017.10.019","article-title":"No. 282-Rural Maternity Care","volume":"39","author":"Miller","year":"2017","journal-title":"J Obstet Gynaecol Can"},{"key":"2026091122151348000_16.9.e110073.5","first-page":"223","article-title":"Problems of providing limited obstetrical services to small, isolated, rural populations","volume":"44","author":"Grzybowski","year":"1998","journal-title":"Can Fam Physician"},{"key":"2026091122151348000_16.9.e110073.6","unstructured":"Leeman L , Leeman R . Do all hospitals need caesarean delivery capability. J Fam Pract 2002;51."},{"key":"2026091122151348000_16.9.e110073.7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.midw.2012.12.005","article-title":"Returning birth: the politics of midwifery implementation on First Nations reserves in Canada","volume":"29","author":"Olson","year":"2013","journal-title":"Midwifery"},{"key":"2026091122151348000_16.9.e110073.8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1701-2163(16)30458-3","article-title":"Is local maternity care an optional service in rural communities?","volume":"27","author":"Kornelsen","year":"2005","journal-title":"J Obstet Gynaecol Can"},{"key":"2026091122151348000_16.9.e110073.9","first-page":"17","article-title":"Closing rural maternity services: Is it worth the risk?","volume":"21","author":"Grzybowski","year":"2016","journal-title":"Can J Rural Med"},{"key":"2026091122151348000_16.9.e110073.10","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/AOG.0000000000004940","article-title":"Predictive models for estimating the probability of successful vaginal birth after caesarean delivery: a systematic review","volume":"140","author":"Black","year":"2022","journal-title":"Obstet Gynecol"},{"key":"2026091122151348000_16.9.e110073.11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bpobgyn.2021.12.005","article-title":"Prediction models for determining the success of labour induction: a systematic review and critical analysis","volume":"79","author":"D\u2019Souza","year":"2022","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2026091122151348000_16.9.e110073.12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1471-0528.2012.03334.x","article-title":"A clinical prediction model to assess the risk of operative delivery","volume":"119","author":"Schuit","year":"2012","journal-title":"BJOG"},{"key":"2026091122151348000_16.9.e110073.13","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/ije\/dyab033","article-title":"Data resource profile: Better Outcomes Registry & Network (BORN) Ontario","volume":"50","author":"Murphy","year":"2021","journal-title":"Int J Epidemiol"},{"key":"2026091122151348000_16.9.e110073.14","unstructured":"Provincial council for maternal and child health. 2023. Available: https:\/\/www.pcmch.on.ca\/wp-content\/uploads\/Perinatal_Birthing_Newborn_Levels_of_Care_Guidance_Document.pdf [Accessed 26 May 2025]."},{"key":"2026091122151348000_16.9.e110073.15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014508"},{"key":"2026091122151348000_16.9.e110073.16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13054-018-2215-6","article-title":"Development and internal validation of the multivariable CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) clinical risk prediction model","volume":"22","author":"Payne","year":"2018","journal-title":"Crit Care"},{"key":"2026091122151348000_16.9.e110073.17","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0698"},{"key":"2026091122151348000_16.9.e110073.18","unstructured":"Harrell FE , Dupont CD . HMISC: Harrell miscellaneous [computer program]. Version 5.1-0. R package; 2025. Available: https:\/\/cran.r-project.org\/package=Hmisc [Accessed 2 Jun 2025]."},{"key":"2026091122151348000_16.9.e110073.19","doi-asserted-by":"publisher","DOI":"10.1080\/10629360600810434"},{"key":"2026091122151348000_16.9.e110073.20","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"2026091122151348000_16.9.e110073.21","doi-asserted-by":"crossref","unstructured":"Harrell FE . Regression modeling strategies: With applications to linear models, logistic regression, and survival analysis. 2nd edn. Springer, 2015.","DOI":"10.1007\/978-3-319-19425-7"},{"key":"2026091122151348000_16.9.e110073.22","doi-asserted-by":"crossref","unstructured":"Little RJ , Rubin DB . Statistical analysis with missing data. 3rd edn. Wiley & Sons, 2019.","DOI":"10.1002\/9781119482260"},{"key":"2026091122151348000_16.9.e110073.23","unstructured":"Harrell Jr F . RMS: regression modeling strategies. R package version 8.1-2. Available: https:\/\/github.com\/harrelfe\/rms [Accessed 22 Apr 2026]."},{"key":"2026091122151348000_16.9.e110073.24","unstructured":"H\u00f8jsgaard S , Halekoh U , geepack YJ . Geepack: generalized estimating equation models [computer program]. Version 1.3-4. R package; 2023. Available: https:\/\/cran.r-project.org\/package=geepack [Accessed 2 Jun 2025]."},{"key":"2026091122151348000_16.9.e110073.25","unstructured":"R Core Team . R: a language and environment for statistical computing [computer program]. Version 4.3.3. R Foundation for Statistical Computing; 2024. Available: https:\/\/www.R-project.org [Accessed 2 Jun 2025]."},{"key":"2026091122151348000_16.9.e110073.26","unstructured":"Harrell FE . RMS: regression modeling strategies [computer program]. Version 6.7-0. R package. Available: https:\/\/cran.r-project.org\/package=rms [Accessed 2 Jun 2025]."},{"key":"2026091122151348000_16.9.e110073.27","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-023-05898-7","article-title":"System interventions to support rural access to maternity care: an analysis of the rural surgical obstetrical networks program","volume":"23","author":"Kornelsen","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"key":"2026091122151348000_16.9.e110073.28","unstructured":"National Rural Health Association . Obstetric readiness in rural communities lacking hospital labour & delivery units. 2023. Available: https:\/\/www.ruralhealth.us\/getmedia\/1aade569-b828-41de-96ed-de76e76365f8\/NRHA-Policy-Brief-Final-Draft-OB-readiness.pdf#:~:text=This%20policy%20brief%20offers%20recommendations%20to%20promote%20obstetric,as%20doulas%2C%20community%20health%20workers%2C%20and%20social%20workers"},{"key":"2026091122151348000_16.9.e110073.29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286287","article-title":"Pregnancy outcomes in women with gestational hypertension and pre-eclampsia at Paropakar Maternity and Women\u2019s Hospital, Nepal: a retrospective study","volume":"18","author":"Das","year":"2023","journal-title":"PLoS One"},{"key":"2026091122151348000_16.9.e110073.30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejogrb.2025.02.052","article-title":"Prediction models for intrapartum fetal hypoxia: a systematic review","volume":"308","author":"Giles-Clark","year":"2025","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2026091122151348000_16.9.e110073.31","doi-asserted-by":"crossref","first-page":"101604","DOI":"10.1016\/j.ajogmf.2025.101604","article-title":"High- vs low-dose oxytocin regimens for labour augmentation: a systematic review and meta-analysis","volume":"7","author":"Logue","year":"2025","journal-title":"Am J Obstet Gynecol MFM"},{"key":"2026091122151348000_16.9.e110073.32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0268229","article-title":"Prediction of odds for emergency caesarean section: a secondary analysis of the CHILD term birth cohort study","volume":"17","author":"Tun","year":"2022","journal-title":"PLoS One"},{"key":"2026091122151348000_16.9.e110073.33","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-022-04625-y","article-title":"Comparing pregnancy, childbirth and neonatal outcomes in women with idiopathic polyhydramnios: a prospective cohort study","volume":"22","author":"Vanda","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"2026091122151348000_16.9.e110073.34","first-page":"26","article-title":"Gravidity and parity definitions (and their implications in risk assessment)","volume":"1324","author":"Borton","year":"2009","journal-title":"Doc"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-110073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:15:33Z","timestamp":1789190133000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-110073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,11]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1136\/bmjopen-2025-110073"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-110073","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}