{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:06:16Z","timestamp":1779793576000,"version":"3.53.1"},"reference-count":61,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"unspecified","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,4,24]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Zo\u012b cohort is a prospective longitudinal cohort study, designed to advance personalised prevention by systematically screening for undiagnosed or asymptomatic conditions, identifying early risk markers and predicting future disease risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Recruitment takes place in a dedicated prevention-focused health centre. Adults aged 18 years and older are enrolled either as paying customers or through company-sponsored programmes. This manuscript presents the design of the cohort and the characteristics of the first 1000 participants (67.5% male, mean age 51.1 years, high education levels). The cohort exhibits a healthy volunteer bias, with lower smoking and obesity rates and higher educational attainment than the general French population, which limits generalisability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>Data collection is conducted in a standardised environment and combines over 500 self-reported items, clinical examinations, extensive biomarker profiling (196 biomarkers) and multimodal imaging (vascular, breast, abdominal and pelvic ultrasound, full-body composition, retinal scan). For several major diseases, risk is further estimated through established clinical prediction models. Despite lower obesity and smoking rates than the general population, almost half (45.6%) of those who reported no ongoing diseases had at least one undiagnosed chronic condition, most frequently hypertension and hypercholesterolaemia. Male sex and older age were significantly associated with disease unawareness (p&lt;0.05). These findings highlight a discrepancy between self-reported and objectively measured health status, even in a health-conscious population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>Longitudinal follow-up is collected via yearly re-evaluations and through a dedicated application. The cohort is designed as a deeply phenotyped, longitudinal resource to support interdisciplinary research collaborations, the development and validation of early risk stratification models and the evaluation of preventive interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-111119","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:05:19Z","timestamp":1779786319000},"page":"e111119","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Zo\u012b cohort, a prospective cohort with comprehensive phenotyping for preventive medicine in France, first 1000 participants: cohort profile"],"prefix":"10.1136","volume":"16","author":[{"given":"Pierre","family":"Bauvin","sequence":"first","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaedine","family":"Benani","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"},{"name":"Service de m\u00e9decine vasculaire, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"},{"name":"Universit\u00e9 Sorbonne Paris Nord, INSERM, Limics, Sorbonne Universite, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4159-244X","authenticated-orcid":false,"given":"Maryne","family":"Lepoittevin","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Sentilhes","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bringer","sequence":"additional","affiliation":[{"name":"H\u00f4pital Sainte-Anne, Groupe Hospitalier Universitaire Paris psychiatrie & neurosciences P\u00f4le Neuro Sainte-Anne, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djihane Ahmed","family":"Lecheheb","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"De Luca","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ohayon","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Dalle","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Data Science and AI Lab, Zo\u012b SAS, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Tannier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord, INSERM, Limics, Universite Sorbonne Paris Nord, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bichat, Paris, Bichat - Claude-Bernard Hospital Cardiology Service, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Bodard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, Service d\u2019Imagerie Adulte, Necker-Enfants Malades Hospitals, Paris, France"},{"name":"CNRS UMR 7371, INSERM U 1146, Laboratoire d\u2019Imagerie Biom\u00e9dicale (LIB), Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026052603465139000_16.5.e111119.1","doi-asserted-by":"crossref","unstructured":"De la Torre K , Min S , Lee H , et al . The application of preventive medicine in the future digital health era. J Med Internet Res 2025;27. doi:10.2196\/59165","DOI":"10.2196\/59165"},{"key":"2026052603465139000_16.5.e111119.2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11019-016-9683-8","article-title":"The new holism: P4 systems medicine and the medicalization of health and life itself","volume":"19","author":"Vogt","year":"2016","journal-title":"Med Health Care and Philos"},{"key":"2026052603465139000_16.5.e111119.3","doi-asserted-by":"crossref","unstructured":"Tuena C , Semonella M , Fern\u00e1ndez-\u00c1lvarez J , et al . Predictive Precision Medicine: Towards the Computational Challenge. 2020. Cham: Springer International Publishing, n.d.:71\u201386.","DOI":"10.1007\/978-3-030-27994-3_5"},{"key":"2026052603465139000_16.5.e111119.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01746-x"},{"key":"2026052603465139000_16.5.e111119.5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3917\/regar.061.0055","article-title":"Les d\u00e9penses de pr\u00e9vention, complexes \u00e0 mesurer, tr\u00e8s difficiles \u00e0 comparer\u2026","volume":"N\u00b0 61","author":"Raynaud","year":"2023","journal-title":"Regards"},{"key":"2026052603465139000_16.5.e111119.6","unstructured":"State of Health in the EU Cycle . Health at a glance: Europe. 2022."},{"key":"2026052603465139000_16.5.e111119.7","doi-asserted-by":"crossref","unstructured":"Elmadani M , Mokaya PO , Omer AAA , et al . Cancer burden in Europe: a systematic analysis of the GLOBOCAN database (2022). BMC Cancer 2025;25. doi:10.1186\/s12885-025-13862-1","DOI":"10.1186\/s12885-025-13862-1"},{"key":"2026052603465139000_16.5.e111119.8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/hcs2.115","article-title":"Revolutionizing healthcare and medicine: the impact of modern technologies for a healthier future-A comprehensive review","volume":"3","author":"Thacharodi","year":"2024","journal-title":"Health Care Sci"},{"key":"2026052603465139000_16.5.e111119.9","unstructured":"WHO . France\u2019s new global health strategy. n.d."},{"key":"2026052603465139000_16.5.e111119.10","unstructured":"Or Z , Gandr\u00e9 C , Sepp\u00e4nen A-V , eds. France: Health System Review. Copenhagen \u00d8, Denmark: WHO Regional Office for Europe, 2023."},{"key":"2026052603465139000_16.5.e111119.11","doi-asserted-by":"crossref","unstructured":"Mosadeghrad AM , Afshari M , Isfahani P , et al . Strategies to strengthen the resilience of primary health care in the COVID-19 pandemic: a scoping review. BMC Health Serv Res 2024;24. doi:10.1186\/s12913-024-11278-4","DOI":"10.1186\/s12913-024-11278-4"},{"key":"2026052603465139000_16.5.e111119.12","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0096-4"},{"key":"2026052603465139000_16.5.e111119.13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.annepidem.2018.09.001","article-title":"Epidemiologic analyses with error-prone exposures: review of current practice and recommendations","volume":"28","author":"Shaw","year":"2018","journal-title":"Ann Epidemiol"},{"key":"2026052603465139000_16.5.e111119.14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/echo.15640","article-title":"Inter-center reproducibility of standard and advanced echocardiographic parameters in the EACVI-AFib echo registry","volume":"40","author":"Santoro","year":"2023","journal-title":"Echocardiography"},{"key":"2026052603465139000_16.5.e111119.15","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00125-017-4518-6","article-title":"Promises and pitfalls of electronic health record analysis","volume":"61","author":"Farmer","year":"2018","journal-title":"Diabetologia"},{"key":"2026052603465139000_16.5.e111119.16","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000036568.02655.f8"},{"key":"2026052603465139000_16.5.e111119.17","doi-asserted-by":"crossref","unstructured":"Toledano MB , Smith RB , Brook JP , et al . How to establish and follow up a large prospective cohort study in the 21st century - lessons from UK COSMOS. PLoS One 2015;10. doi:10.1371\/journal.pone.0131521","DOI":"10.1371\/journal.pone.0131521"},{"key":"2026052603465139000_16.5.e111119.18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygyno.2024.01.008","article-title":"How far is too far? Cancer prevention and clinical trial enrollment in geographically underserved patient populations","volume":"184","author":"Ring","year":"2024","journal-title":"Gynecol Oncol"},{"key":"2026052603465139000_16.5.e111119.19","doi-asserted-by":"crossref","DOI":"10.1016\/j.respe.2014.06.049","article-title":"Disparit\u00e9s r\u00e9gionales de la mortalit\u00e9 pr\u00e9matur\u00e9e par maladies cardiovasculaires et \u00e9volutions temporelles, France","volume":"62","author":"Gabet","year":"2014","journal-title":"Revue d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique"},{"key":"2026052603465139000_16.5.e111119.20","doi-asserted-by":"crossref","unstructured":"Wang H , Roy S , Kim J , et al . Barriers of colorectal cancer screening in rural USA: a systematic review. Rural Remote Health 2019. doi:10.22605\/RRH5181","DOI":"10.22605\/RRH5181"},{"key":"2026052603465139000_16.5.e111119.21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.puhe.2015.04.001","article-title":"Exposing some important barriers to health care access in the rural USA","volume":"129","author":"Douthit","year":"2015","journal-title":"Public Health (Fairfax)"},{"key":"2026052603465139000_16.5.e111119.22","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1200\/OP.22.00122","article-title":"The road less traveled: transportation barriers to cancer care delivery in the rural patient population","volume":"18","author":"Wercholuk","year":"2022","journal-title":"JCO Oncol Pract"},{"key":"2026052603465139000_16.5.e111119.23","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1093\/cvr\/cvab316","article-title":"Environmental risk factors and cardiovascular diseases: a comprehensive expert review","volume":"118","author":"M\u00fcnzel","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2026052603465139000_16.5.e111119.24","first-page":"733","article-title":"Cardiovascular risk factors and prevention: a perspective from developing countries","volume":"37","author":"Teo","year":"2021","journal-title":"Can J Cardiol"},{"key":"2026052603465139000_16.5.e111119.25","doi-asserted-by":"crossref","unstructured":"Tokgozoglu L , Hekimsoy V , Costabile G , et al . Diet, Lifestyle, Smoking. Berlin, Heidelberg: Springer, 2020.","DOI":"10.1007\/164_2020_353"},{"key":"2026052603465139000_16.5.e111119.26","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31816d83e4"},{"key":"2026052603465139000_16.5.e111119.27","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"2026052603465139000_16.5.e111119.28","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1451-2"},{"key":"2026052603465139000_16.5.e111119.29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neubiorev.2010.07.007","article-title":"Neurotransmitters excreted in the urine as biomarkers of nervous system activity: validity and clinical applicability","volume":"35","author":"Marc","year":"2011","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"2026052603465139000_16.5.e111119.30","first-page":"441","article-title":"Optical coherence tomography: from research to clinical application","volume":"103","author":"Alfonso","year":"2012","journal-title":"Minerva Med"},{"key":"2026052603465139000_16.5.e111119.31","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2007.S5"},{"key":"2026052603465139000_16.5.e111119.32","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"2026052603465139000_16.5.e111119.33","doi-asserted-by":"crossref","unstructured":"Arnett DK , Blumenthal RS , Albert MA , et al . 2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of cardiology\/american heart association task force on clinical practice guidelines. Circulation 2019;140. doi:10.1161\/CIR.0000000000000678","DOI":"10.1161\/CIR.0000000000000725"},{"key":"2026052603465139000_16.5.e111119.34","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(24)00316-4"},{"key":"2026052603465139000_16.5.e111119.35","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1376"},{"key":"2026052603465139000_16.5.e111119.36","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab312"},{"key":"2026052603465139000_16.5.e111119.37","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab309"},{"key":"2026052603465139000_16.5.e111119.38","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad260"},{"key":"2026052603465139000_16.5.e111119.39","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215158"},{"key":"2026052603465139000_16.5.e111119.40","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0206"},{"key":"2026052603465139000_16.5.e111119.41","doi-asserted-by":"crossref","first-page":"955287","DOI":"10.3389\/fpubh.2022.955287","article-title":"Development and validation of a risk prediction model for incident liver cancer","volume":"10","author":"Liu","year":"2022","journal-title":"Front Public Health"},{"key":"2026052603465139000_16.5.e111119.42","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1668"},{"key":"2026052603465139000_16.5.e111119.43","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.10.1068"},{"key":"2026052603465139000_16.5.e111119.44","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1667077"},{"key":"2026052603465139000_16.5.e111119.45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-0044-1778693","article-title":"Development and validation of a natural language processing algorithm to pseudonymize documents in the context of a clinical data warehouse","volume":"63","author":"Tannier","year":"2024","journal-title":"Methods Inf Med"},{"key":"2026052603465139000_16.5.e111119.46","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S2589-7500(24)00224-3","article-title":"Tackling algorithmic bias and promoting transparency in health datasets: the STANDING Together consensus recommendations","volume":"7","author":"Alderman","year":"2025","journal-title":"The Lancet Digital Health"},{"key":"2026052603465139000_16.5.e111119.47","doi-asserted-by":"crossref","first-page":"108252","DOI":"10.1016\/j.diabres.2020.108252","article-title":"Prevalence of prediabetes and undiagnosed type 2 diabetes in France: results from the national survey ESTEBAN, 2014\u20132016","volume":"165","author":"Lailler","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"2026052603465139000_16.5.e111119.48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3917\/spub.pr1.0021","article-title":"\u00c9tat des lieux de la situation du tabagisme en France : tendances observ\u00e9es et nouveaux enjeux","volume":"Vol. 35","author":"Obradovic","year":"2023","journal-title":"Sant\u00e9 Publique"},{"key":"2026052603465139000_16.5.e111119.49","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-024-19437-2","article-title":"Trends and social inequalities in self-reported health and activity limitations in France between 2017 and 2021: results from four nationwide representative surveys","volume":"24","author":"Lahbib","year":"2024","journal-title":"BMC Public Health"},{"key":"2026052603465139000_16.5.e111119.50","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12030925","article-title":"Prevalence of overweight and obesity in France: the 2020 Obepi-Roche study by the \u201cLigue Contre l\u2019Ob\u00e9sit\u00e9\u201d","volume":"12","author":"Fontbonne","year":"2023","journal-title":"J Clin Med"},{"key":"2026052603465139000_16.5.e111119.51","doi-asserted-by":"crossref","unstructured":"Aguilera-Buenosvinos I , Morales Berstein F , Gonz\u00e1lez-Gil EM , et al . Adherence to the mediterranean diet and obesity-linked cancer risk in EPIC. JAMA Netw Open 2025;8. doi:10.1001\/jamanetworkopen.2024.61031","DOI":"10.1001\/jamanetworkopen.2024.61031"},{"key":"2026052603465139000_16.5.e111119.52","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Gil EM , Matta M , Morales Berstein F , et al . Associations between degree of food processing and all-cause and cause-specific mortality: a multicentre prospective cohort analysis in 9 European countries. Lancet Reg Health Eur 2025;50. doi:10.1016\/j.lanepe.2024.101208","DOI":"10.1016\/j.lanepe.2024.101208"},{"key":"2026052603465139000_16.5.e111119.53","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"2026052603465139000_16.5.e111119.54","doi-asserted-by":"publisher","DOI":"10.1016\/J.KINT.2023.10.018"},{"key":"2026052603465139000_16.5.e111119.55","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-023-00602-4"},{"key":"2026052603465139000_16.5.e111119.56","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.3390\/ijms24032813","article-title":"The association between apolipoprotein b, cardiovascular risk factors and subclinical atherosclerosis\u2014findings from the SEPHAR national registry on hypertension in Romania","volume":"24","author":"Doroban\u021bu","year":"2023","journal-title":"IJMS"},{"key":"2026052603465139000_16.5.e111119.57","doi-asserted-by":"crossref","unstructured":"Varoquaux G , Luccioni S , Whittaker M . Hype, sustainability, and the price of the bigger-is-better paradigm in AI. 2024.","DOI":"10.1145\/3715275.3732006"},{"key":"2026052603465139000_16.5.e111119.58","first-page":"E934","article-title":"Prevention of cardiovascular diseases and diabetes: importance of a screening program for the early detection of risk conditions in a target population","volume":"62","author":"Facciol\u00e0","year":"2021","journal-title":"J Prev Med Hyg"},{"key":"2026052603465139000_16.5.e111119.59","doi-asserted-by":"crossref","unstructured":"Field J , Vulkan D , Davies M , et al . FP09.02 calibration of the LLP lung cancer risk stratification model: prospective validation in the UKLS cohort of 76,000 people. J Thorac Oncol 2021;16. doi:10.1016\/j.jtho.2021.01.119","DOI":"10.1016\/j.jtho.2021.01.119"},{"key":"2026052603465139000_16.5.e111119.60","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad318"},{"key":"2026052603465139000_16.5.e111119.61","doi-asserted-by":"crossref","unstructured":"Guillaudeux M , Rousseau O , Petot J , et al . Patient-centric synthetic data generation, no reason to risk re-identification in biomedical data analysis. NPJ Digit Med 2023;6. doi:10.1038\/s41746-023-00771-5","DOI":"10.1038\/s41746-023-00771-5"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-111119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:51:54Z","timestamp":1779792714000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-111119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,26]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1136\/bmjopen-2025-111119"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-111119","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}