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Community-based health systems strengthening (HSS) interventions are emerging as a strategy towards effective prevention of mother-to-child transmission (PMTCT) of HIV services. However, the nexus between interventions and impact indicators remains unclear. This systematic review aims to assess all available evidence on the impact of community-driven HSS interventions on PMTCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will develop a search of studies published between 2015 and 2025 from databases such as PubMed\/Medline, Scopus, Web of Science, Google Scholar and African Journals. We will use a combination of search terms such as \u2018participatory action research\u2019, \u2018health systems strengthening\u2019, \u2018PMTCT of HIV\u2019, \u2018childhood HIV\u2019, \u2018MTCT of HIV\u2019 and \u2018under-five mortality\u2019. Studies aimed at community-based participatory health system intervention on PMTCT of HIV published in English will be used. Experimental, quasi-experimental and observational (including cohort and case-control) studies will be included. Data will be analysed using narrative and meta-analysis approaches. The risk of bias will be assessed using Cochrane Handbook guidelines. The primary outcome measure will cover PMTCT of HIV and secondary outcome measures are HIV prevalence and under-five mortality. Finally, the quality of evidence will be assessed using Grades of Recommendation, Assessment, Development and Evaluation technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>As no original data will be collected, ethical approval is not applicable for this study. The results will be disseminated through peer-reviewed publication and presentations at health summits and conferences. The review would inform context-sensitive HIV policies and interventions in developing countries, particularly for women and children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD420251131511.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-112977","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T17:42:59Z","timestamp":1774806179000},"page":"e112977","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of community-based participatory health systems interventions on prevention of mother-to-child transmission of HIV (PMTCT) in sub-Saharan Africa: a systematic review and meta-analysis protocol"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-175X","authenticated-orcid":false,"given":"Samuel","family":"Amon","sequence":"first","affiliation":[{"name":"Regional Institute for Population Studies (RIPS), University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvester","family":"Amankwah","sequence":"additional","affiliation":[{"name":"Ejisu Municipal Health Directorate, Ghana Health Service, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet Awopole Yepakeh","family":"Tiah","sequence":"additional","affiliation":[{"name":"Regional Institute for Population Studies (RIPS), University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves Jacket","family":"Nsavyimana","sequence":"additional","affiliation":[{"name":"Centre for Health Policy Analysis and Research, Bujumbura, Burundi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-7433","authenticated-orcid":false,"given":"Caesar","family":"Agula","sequence":"additional","affiliation":[{"name":"Regional Institute for Population Studies (RIPS), University of Ghana, Legon, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"2026032910424824000_16.3.e112977.1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clindermatol.2024.02.001","article-title":"The global burden of HIV","volume":"42","author":"Payagala","year":"2024","journal-title":"Clin Dermatol"},{"key":"2026032910424824000_16.3.e112977.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003831","article-title":"Modeling the epidemiological impact of the UNAIDS 2025 targets to end AIDS as a public health threat by 2030","volume":"18","author":"Stover","year":"2021","journal-title":"PLoS Med"},{"key":"2026032910424824000_16.3.e112977.3","doi-asserted-by":"crossref","unstructured":"Lule F . 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