{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:52:30Z","timestamp":1782492750824,"version":"3.54.5"},"reference-count":27,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003542","name":"Ministerium f\u00fcr Wissenschaft, Forschung und Kunst Baden-W\u00fcrttemberg","doi-asserted-by":"crossref","award":["MWK-33-7532-56\/21\/4"],"award-info":[{"award-number":["MWK-33-7532-56\/21\/4"]}],"id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,2,20]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a severe, multisystem condition that often emerges after viral infections and affects physical and cognitive function. Severely affected patients are underrepresented in research due to immobility and exertional intolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, non-interventional observational study investigating the feasibility and tolerability of home-based diagnostics in patients with severe and very severe ME\/CFS. Phase 1 includes remote identification using validated questionnaires. Phase 2 involves home visits for physiological, cognitive and biological assessments. The primary outcome is feasibility; secondary outcomes include tolerability and methodological barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics\/dissemination<\/jats:title>\n                    <jats:p>The study protocol was approved by the Ethics Committee of the University of Freiburg (No. 25-1031-S1). Written informed consent is obtained from all participants. Results will be disseminated via peer-reviewed publications and patient support groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>DRKS00035231; FRKS005506.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-113095","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:35:29Z","timestamp":1772807729000},"page":"e113095","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["ACHTSAM study protocol: outreach diagnostics and assessment of tolerability in severe ME\/CFS\u2014a pilot study"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6956-9217","authenticated-orcid":false,"given":"Carmen","family":"Fricke","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Bewegungs- und Arbeitsmedizin, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Deibert","sequence":"additional","affiliation":[{"name":"University of Freiburg, Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Maier","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Bewegungs- und Arbeitsmedizin, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-358X","authenticated-orcid":false,"given":"Winfried","family":"Kern","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Krumnau","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Bewegungs- und Arbeitsmedizin, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Barsch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Bewegungs- und Arbeitsmedizin, Universit\u00e4tsklinikum Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"2026062609354699000_16.3.e113095.1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00508-024-02372-y","article-title":"Interdisziplin\u00e4res, kollaboratives D-A-CH Konsensus-Statement zur Diagnostik und Behandlung von Myalgischer Enzephalomyelitis\/Chronischem Fatigue-Syndrom","volume":"136","author":"Hoffmann","year":"2024","journal-title":"Wien Klin Wochenschr"},{"key":"2026062609354699000_16.3.e113095.2","first-page":"510","article-title":"European Network on Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME\/CFS in Europe","volume":"57","author":"Nacul","year":"2021","journal-title":"Med Bogota Colomb"},{"key":"2026062609354699000_16.3.e113095.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01810-6"},{"key":"2026062609354699000_16.3.e113095.4","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s00108-022-01369-x","article-title":"Post-COVID-Syndrom mit Fatigue und Belastungsintoleranz: Myalgische Enzephalomyelitis bzw. 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