{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:32:40Z","timestamp":1787239960545,"version":"build-2736575974"},"reference-count":65,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22de0107005"],"award-info":[{"award-number":["JP22de0107005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,3,5]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The global burden of depression continues to rise despite evidence that prevention is feasible and cost-effective. Building on the Resilience Enhancement with Smartphone in Living ENvironmenTs (RESiLIENT) randomised controlled trial, the Best, Efficient and Affordable Training in Resilience in Constant Evolution (BEATRICE) platform trial evaluates and optimises smartphone-delivered cognitive\u2013behavioural therapy (CBT) for adults with no to subthreshold depression. The primary objective is to minimise the Total Burden of Depression, measured by the integral of weekly to monthly Patient Health Questionnaire-8 (PHQ-8) scores over 12 months, through a living, adaptive platform trial that sequentially tests multiple clinical questions and personalised algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>BEATRICE is a nationwide, digitally centralised, multi-arm platform trial conducted via the \u2018Resilience Training App\u2019. Eligible participants are adults (aged \u226518 years) with PHQ-8 \u226414, fluent in Japanese, owning a smartphone and not currently receiving mental health treatment. Recruitment takes place through health-insurance associations, companies, municipalities and online outreach. Participants are randomised centrally to CBT skill modules\u2014behavioural activation, assertion training, behaviour therapy for insomnia, cognitive restructuringor problem-solving\u2014delivered alone or in combination. Assessments are open-label and completed digitally by self-reports.<\/jats:p>\n                    <jats:p>The initial list of clinical questions to be examined in this platform trial includes: external validity of the personalised and optimised algorithm for first-line interventions, strategies to help individuals not on track during initial weeks, second-line interventions at 6\u2009months, development of super-personalised and optimised therapy algorithm, that is, longitudinally personalised and optimised in response to individuals\u2019 responses after the first-line assignment. The primary outcomes, sample sizes and statistical analyses differ depending on the clinical question addressed within the platform trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Approved by the Ethics Committee of Kyoto University Graduate School of Medicine (C1733). Results will be disseminated via peer-reviewed publications, conferences and public reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>UMIN000058696.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-113603","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:45:21Z","timestamp":1774626321000},"page":"e113603","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Platform trial of smartphone-based cognitive\u2013behavioural therapy (CBT) for depressive symptoms among people with no or subthreshold depression: a protocol for the Best, Efficient and Affordable Training in Resilience in Constant Evolution (BEATRICE) platform trial"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-3776","authenticated-orcid":false,"given":"Toshi A","family":"Furukawa","sequence":"first","affiliation":[{"name":"Office of Institutional Advancement and Communications, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-9949","authenticated-orcid":false,"given":"Hisashi","family":"Noma","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Statistical Mathematics, The Institute of Statistical Mathematics, Tachikawa, Japan"},{"name":"The Graduate Institute for Advanced Studies, The Graduate University for Advanced Studies, Tachikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-7692","authenticated-orcid":false,"given":"Masahiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Data Science for Business Innovation, Chuo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-8867","authenticated-orcid":false,"given":"Aran","family":"Tajika","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Behavioral Sciences, Graduate School of Medicine\/School of Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1125-3145","authenticated-orcid":false,"given":"Rie","family":"Toyomoto","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Behavioral Sciences, Graduate School of Medicine\/School of Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-5263","authenticated-orcid":false,"given":"Masatsugu","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Neurodevelopmental Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-5126","authenticated-orcid":false,"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Next-Generation Organ Transplantation, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-9785","authenticated-orcid":false,"given":"Kosuke","family":"Inoue,","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Behavioral Sciences, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-8813","authenticated-orcid":false,"given":"Masaru","family":"Horikoshi","sequence":"additional","affiliation":[{"name":"Musashino University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-7518","authenticated-orcid":false,"given":"Tatsuo","family":"Akechi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-2720","authenticated-orcid":false,"given":"Norito","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Digital Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6425-6844","authenticated-orcid":false,"given":"Naoki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Social Epidemiology, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-6252","authenticated-orcid":false,"given":"Takeo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-8761","authenticated-orcid":false,"given":"Shingo","family":"Fukuma","sequence":"additional","affiliation":[{"name":"Department of Healthcare Epidemiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-2065","authenticated-orcid":false,"given":"Helen","family":"Christensen","sequence":"additional","affiliation":[{"name":"Black Dog Institute, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-2172","authenticated-orcid":false,"given":"Alexis","family":"Whitton","sequence":"additional","affiliation":[{"name":"Black Dog Institute, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-3847","authenticated-orcid":false,"given":"Wolfgang","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Psychology, Trier University, Trier, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-2743","authenticated-orcid":false,"given":"Pim","family":"Cuijpers","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology, Amsterdam, Vrije Universiteit Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-2305","authenticated-orcid":false,"given":"Ronald C","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-126X","authenticated-orcid":false,"given":"James","family":"Wason","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK"},{"name":"MRC Biostatistics Unit, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6138-9089","authenticated-orcid":false,"given":"Inbal","family":"Nahum-Shani","sequence":"additional","affiliation":[{"name":"Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"2026032708451358000_16.3.e113603.1","unstructured":"Lobel B , Hirschfeld RM . Depression: What We Know (DHHS Publication No.ADM 84-1318). Rockville, MD: National Institute of Mental Health, 1984."},{"key":"2026032708451358000_16.3.e113603.2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S2215-0366(24)00316-X","article-title":"Psychological interventions to prevent the onset of major depression in adults: a systematic review and individual participant data meta-analysis","volume":"11","author":"Buntrock","year":"2024","journal-title":"Lancet Psychiatry"},{"key":"2026032708451358000_16.3.e113603.3","unstructured":"Australian Government National Mental Health Commission . The economic case for investing in mental health prevention: summary. 2021."},{"key":"2026032708451358000_16.3.e113603.4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/acps.13108","article-title":"An epidemic or a plague of common mental disorders?","volume":"140","author":"Furukawa","year":"2019","journal-title":"Acta Psychiatr Scand"},{"key":"2026032708451358000_16.3.e113603.5","unstructured":"WHO . The global burden of disease: 2004 update. 2008. Available: http:\/\/www.who.int\/healthinfo\/global_burden_disease\/2004_report_update\/en\/index.html"},{"key":"2026032708451358000_16.3.e113603.6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)02141-3","article-title":"Time for united action on depression: a lancet\u2013world psychiatric association commission","volume":"399","author":"Herrman","year":"2022","journal-title":"The Lancet"},{"key":"2026032708451358000_16.3.e113603.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01288.x"},{"key":"2026032708451358000_16.3.e113603.8","doi-asserted-by":"publisher","DOI":"10.1177\/0020764010371273"},{"key":"2026032708451358000_16.3.e113603.9","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1038\/s41591-025-03639-1","article-title":"Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial","volume":"31","author":"Furukawa","year":"2025","journal-title":"Nat Med"},{"key":"2026032708451358000_16.3.e113603.10","doi-asserted-by":"crossref","unstructured":"Toyomoto R , Tajika A , Luo Y , et al . Smartphone based cognitive behavioural therapy for adults with no or minimal depressive symptoms in Japan: an exploratory secondary analysis of RESiLIENT trial. Lancet Reg Health West Pac 2025;64. doi:10.1016\/j.lanwpc.2025.101741","DOI":"10.1016\/j.lanwpc.2025.101741"},{"key":"2026032708451358000_16.3.e113603.11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41746-025-01906-6","article-title":"Personalised & optimised therapy (POT) algorithm using five cognitive and behavioural skills for subthreshold depression","volume":"8","author":"Furukawa","year":"2025","journal-title":"npj Digit Med"},{"key":"2026032708451358000_16.3.e113603.12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s44159-021-00012-0","article-title":"Platform trials and the future of evaluating therapeutic behavioural interventions","volume":"1","author":"Gold","year":"2022","journal-title":"Nat Rev Psychol"},{"key":"2026032708451358000_16.3.e113603.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22507"},{"key":"2026032708451358000_16.3.e113603.14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/met0000219","article-title":"SMART longitudinal analysis: a tutorial for using repeated outcome measures from SMART studies to compare adaptive interventions","volume":"25","author":"Nahum-Shani","year":"2020","journal-title":"Psychol Methods"},{"key":"2026032708451358000_16.3.e113603.15","doi-asserted-by":"publisher","DOI":"10.1177\/1740774513517063"},{"key":"2026032708451358000_16.3.e113603.16","doi-asserted-by":"crossref","unstructured":"Chan A-W , Boutron I , Hopewell S , et al . SPIRIT 2025 statement: updated guideline for protocols of randomised trials. BMJ 2025;389. doi:10.1136\/bmj-2024-081477","DOI":"10.1136\/bmj-2024-081477"},{"key":"2026032708451358000_16.3.e113603.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.026"},{"key":"2026032708451358000_16.3.e113603.18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"2026032708451358000_16.3.e113603.19","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1017\/S0033291719001314","article-title":"Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis","volume":"50","author":"Wu","year":"2020","journal-title":"Psychol Med"},{"key":"2026032708451358000_16.3.e113603.20","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1007\/s11136-017-1659-5","article-title":"Standardization of health outcomes assessment for depression and anxiety: recommendations from the ICHOM Depression and Anxiety Working Group","volume":"26","author":"Obbarius","year":"2017","journal-title":"Qual Life Res"},{"key":"2026032708451358000_16.3.e113603.21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S2215-0366(23)00139-6","article-title":"Common measures in mental health: a joint initiative by funders and journals","volume":"10","author":"Farber","year":"2023","journal-title":"Lancet Psychiatry"},{"key":"2026032708451358000_16.3.e113603.22","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.13.1977"},{"key":"2026032708451358000_16.3.e113603.23","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90061-1"},{"key":"2026032708451358000_16.3.e113603.24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jpsychores.2014.03.010","article-title":"Providing patient progress feedback and clinical support tools to therapists: is the therapeutic process of patients on-track to recovery enhanced in psychosomatic in-patient therapy under the conditions of routine practice?","volume":"76","author":"Probst","year":"2014","journal-title":"J Psychosom Res"},{"key":"2026032708451358000_16.3.e113603.25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ebmental-2020-300217","article-title":"Development and validation of the Cognitive Behavioural Therapy Skills Scale among college students","volume":"24","author":"Sakata","year":"2021","journal-title":"Evid Based Ment Health"},{"key":"2026032708451358000_16.3.e113603.26","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00065-4"},{"key":"2026032708451358000_16.3.e113603.27","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0144-4"},{"key":"2026032708451358000_16.3.e113603.28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12955-021-01882-x","article-title":"Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS): performance in a clinical sample in relation to PHQ-9 and GAD-7","volume":"19","author":"Shah","year":"2021","journal-title":"Health Qual Life Outcomes"},{"key":"2026032708451358000_16.3.e113603.29","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700033237"},{"key":"2026032708451358000_16.3.e113603.30","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/mpr.1437","article-title":"One-year test-retest reliability of a Japanese web-based version of the WHO Composite International Diagnostic Interview (CIDI) for major depression in a working population","volume":"24","author":"Shimoda","year":"2015","journal-title":"Int J Methods Psychiatr Res"},{"key":"2026032708451358000_16.3.e113603.31","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.5.461"},{"key":"2026032708451358000_16.3.e113603.32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2486\/indhealth.2019-0090","article-title":"Construct validity and test-retest reliability of the World Mental Health Japan version of the World Health Organization Health and work performance questionnaire short version: a preliminary study","volume":"58","author":"Kawakami","year":"2020","journal-title":"Ind Health"},{"key":"2026032708451358000_16.3.e113603.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.05.009"},{"key":"2026032708451358000_16.3.e113603.34","doi-asserted-by":"publisher","DOI":"10.1027\/1015-5759\/a000430"},{"key":"2026032708451358000_16.3.e113603.35","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"2026032708451358000_16.3.e113603.36","first-page":"47","article-title":"Developing a Japanese version of the EQ-5D-5L value set","volume":"64","author":"Ikeda","year":"2015","journal-title":"J Natl Inst Public Health (\u4fdd\u5065\u533b\u7642\u79d1\u5b66)"},{"key":"2026032708451358000_16.3.e113603.37","first-page":"152","article-title":"An 8-item short scale for Premenstrual Syndrome (PMS-8): development and assessment of validity and reliability in a Japanese Population. Shinshin-Igaku","volume":"64","author":"Ikeda","year":"2024","journal-title":"Jpn J Psychosom Med"},{"key":"2026032708451358000_16.3.e113603.38","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7189(82)90074-X"},{"key":"2026032708451358000_16.3.e113603.39","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1017\/S0033291716001562","article-title":"Does Internet-based guided-self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials","volume":"46","author":"Ebert","year":"2016","journal-title":"Psychol Med"},{"key":"2026032708451358000_16.3.e113603.40","doi-asserted-by":"publisher","DOI":"10.1037\/\/1040-3590.5.3.350"},{"key":"2026032708451358000_16.3.e113603.41","doi-asserted-by":"crossref","unstructured":"Miguel C , Harrer M , Karyotaki E , et al . Self-reports vs clinician ratings of efficacies of psychotherapies for depression: a meta-analysis of randomized trials. Epidemiol Psychiatr Sci 2025;34. doi:10.1017\/S2045796025000095","DOI":"10.1017\/S2045796025000095"},{"key":"2026032708451358000_16.3.e113603.42","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1214\/06-BA130","article-title":"Loss function based ranking in two-stage, hierarchical models","volume":"1","author":"Lin","year":"2006","journal-title":"Bayesian Anal"},{"key":"2026032708451358000_16.3.e113603.43","doi-asserted-by":"crossref","unstructured":"Carlin BP , Louis TA . Bayesian Methods for Data Analysis. Chapman & Hall, 2009.","DOI":"10.1201\/b14884"},{"key":"2026032708451358000_16.3.e113603.44","doi-asserted-by":"crossref","unstructured":"Riazy L , Grote M , Liegl G , et al . Cross-sectional reference data from 29 European countries for 6 frequently used depression measures. JAMA Netw Open 2025;8. doi:10.1001\/jamanetworkopen.2025.17394","DOI":"10.1001\/jamanetworkopen.2025.17394"},{"key":"2026032708451358000_16.3.e113603.45","unstructured":"Hern\u00e1n MA , Robins JM . Causal inference: what IF. 2020."},{"key":"2026032708451358000_16.3.e113603.46","unstructured":"Lash TL , VanderWeele TJ , Haneuse S , et al . Modern Epidemiology. Wolters Kluwer, 2020."},{"key":"2026032708451358000_16.3.e113603.47","doi-asserted-by":"crossref","unstructured":"Little RJ , Rubin DB . Statistical Analysis with Missing Data. 3rd edn. Wiley, 2019.","DOI":"10.1002\/9781119482260"},{"key":"2026032708451358000_16.3.e113603.48","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1177\/09622802231165001","article-title":"Imputation and missing indicators for handling missing data in the development and deployment of clinical prediction models: a simulation study","volume":"32","author":"Sisk","year":"2023","journal-title":"Stat Methods Med Res"},{"key":"2026032708451358000_16.3.e113603.49","doi-asserted-by":"crossref","unstructured":"Efthimiou O , Seo M , Chalkou K , et al . Developing clinical prediction models: a step-by-step guide. BMJ 2024;386. doi:10.1136\/bmj-2023-078276","DOI":"10.1136\/bmj-2023-078276"},{"key":"2026032708451358000_16.3.e113603.50","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1017\/S0033291718003331","article-title":"Prediction of remission in pharmacotherapy of untreated major depression: development and validation of multivariable prediction models","volume":"49","author":"Furukawa","year":"2019","journal-title":"Psychol Med"},{"key":"2026032708451358000_16.3.e113603.51","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.07m03780"},{"key":"2026032708451358000_16.3.e113603.52","doi-asserted-by":"crossref","first-page":"103438","DOI":"10.1016\/j.brat.2019.103438","article-title":"Towards integrating personalized feedback research into clinical practice: Development of the Trier Treatment Navigator (TTN)","volume":"120","author":"Lutz","year":"2019","journal-title":"Behav Res Ther"},{"key":"2026032708451358000_16.3.e113603.53","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1037\/ccp0000642","article-title":"Prospective evaluation of a clinical decision support system in psychological therapy","volume":"90","author":"Lutz","year":"2022","journal-title":"J Consult Clin Psychol"},{"key":"2026032708451358000_16.3.e113603.54","doi-asserted-by":"publisher","DOI":"10.2307\/4615733"},{"key":"2026032708451358000_16.3.e113603.55","doi-asserted-by":"publisher","DOI":"10.1081\/BIP-100104194"},{"key":"2026032708451358000_16.3.e113603.56","doi-asserted-by":"crossref","unstructured":"Mallinckrodt CH , Lipkovich I . Analyzing Longitudinal Clinical Trial Data: A Practical. Guide: CRC Press, 2016.","DOI":"10.1201\/9781315186634"},{"key":"2026032708451358000_16.3.e113603.57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/jamapsychiatry.2020.4364","article-title":"Internet-based cognitive behavioral therapy for depression: a systematic review and individual patient data network meta-analysis","volume":"78","author":"Karyotaki","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"2026032708451358000_16.3.e113603.58","doi-asserted-by":"crossref","unstructured":"Mohr DC , Schueller SM , Tomasino KN , et al . Comparison of the effects of coaching and receipt of app recommendations on depression, anxiety, and engagement in the intellicare platform: factorial randomized controlled trial. J Med Internet Res 2019;21. doi:10.2196\/13609","DOI":"10.2196\/preprints.13609"},{"key":"2026032708451358000_16.3.e113603.59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S2215-0366(21)00077-8","article-title":"Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data","volume":"8","author":"Furukawa","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"2026032708451358000_16.3.e113603.60","unstructured":"McCulloch CE , Searle SR , Neuhaus JM . GEneralized Linear, and Mixed Models. 2nd edn. Wiley, 2008."},{"key":"2026032708451358000_16.3.e113603.61","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/jamia\/ocz127","article-title":"A nonparametric updating method to correct clinical prediction model drift","volume":"26","author":"Davis","year":"2019","journal-title":"J Am Med Inform Assoc"},{"key":"2026032708451358000_16.3.e113603.62","doi-asserted-by":"crossref","first-page":"104443","DOI":"10.1016\/j.brat.2023.104443","article-title":"Implementing precision methods in personalizing psychological therapies: barriers and possible ways forward","volume":"172","author":"Deisenhofer","year":"2024","journal-title":"Behav Res Ther"},{"key":"2026032708451358000_16.3.e113603.63","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.4088\/JCP.10m06130gry","article-title":"Brief behavioral therapy for refractory insomnia in residual depression: an assessor-blind, randomized controlled trial","volume":"72","author":"Watanabe","year":"2011","journal-title":"J Clin Psychiatry"},{"key":"2026032708451358000_16.3.e113603.64","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/jamapsychiatry.2023.5060","article-title":"Components and delivery formats of cognitive behavioral therapy for chronic Insomnia in adults: a systematic review and component network meta-analysis","volume":"81","author":"Furukawa","year":"2024","journal-title":"JAMA Psychiatry"},{"key":"2026032708451358000_16.3.e113603.65","doi-asserted-by":"crossref","unstructured":"Kohavi R , Tang D , Xu Y . Trustworthy Online Controlled Experiments: A Practical Guide to A\/B Testing. Cambridge, UK: Cambridge University Press, 2020.","DOI":"10.1017\/9781108653985"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-113603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:45:31Z","timestamp":1774626331000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-113603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":65,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,27]]},"published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1136\/bmjopen-2025-113603"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-113603","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}