{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:14:13Z","timestamp":1788444853677,"version":"build-2803163510"},"reference-count":41,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","award":["Innovation in health and life sciences ref 104296"],"award-info":[{"award-number":["Innovation in health and life sciences ref 104296"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["Newcastle In Vitro Diagnostics (ref MIC-2016-014)"],"award-info":[{"award-number":["Newcastle In Vitro Diagnostics (ref MIC-2016-014)"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,4,29]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore healthcare professionals\u2019 perspectives on the potential role of molecular breast imaging (MBI) for breast cancer imaging and to inform future clinical study design and implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Qualitative interview study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>UK National Health Service (NHS) breast screening and diagnostic pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Purposively sampled stakeholders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Semistructured interviews with key professional stakeholders explored potential MBI pathways and routes to adoption, including barriers and facilitators. Data were analysed thematically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>22 participants were recruited between January 2020 and October 2021. Barriers to MBI adoption were identified at three levels: scan-related, system-level, and cultural within the screening programme. Overcoming these is likely necessary for implementation. A further theme highlighted the potential for MBI to improve screening in selected patient groups, contingent on addressing these barriers. Specifically, adoption would require advances in next-generation MBI systems, particularly reductions in radiation dose and scan time, alongside prospective clinical studies in UK populations to assess diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Once identified barriers are overcome, participants perceived that MBI could improve screening pathways, particularly for women with dense breast tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-113676","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:05:19Z","timestamp":1780502719000},"page":"e113676","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Is molecular breast imaging suitable for use in UK breast cancer pathways? A qualitative study exploring healthcare professionals\u2019 perspectives"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-1029","authenticated-orcid":false,"given":"Helen","family":"Elliott","sequence":"first","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"},{"name":"Newcastle University, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Joy","family":"Allen","sequence":"additional","affiliation":[{"name":"Newcastle University, Newcastle upon Tyne, England, UK"},{"name":"NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerys D","family":"Forester","sequence":"additional","affiliation":[{"name":"Newcastle University, Newcastle upon Tyne, England, UK"},{"name":"Radiology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Graziadio","sequence":"additional","affiliation":[{"name":"NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle upon Tyne, England, UK"},{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Stephen","family":"Jones","sequence":"additional","affiliation":[{"name":"Newcastle University, Newcastle upon Tyne, England, UK"},{"name":"NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Lendrem","sequence":"additional","affiliation":[{"name":"Newcastle University, Newcastle upon Tyne, England, UK"},{"name":"NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pearce","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Powell","sequence":"additional","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"},{"name":"Newcastle University, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Bray","sequence":"additional","affiliation":[{"name":"Northern Medical Physics and Clinical Engineering, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK"},{"name":"Newcastle University, Newcastle upon Tyne, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-2171","authenticated-orcid":false,"given":"Jason","family":"Scott","sequence":"additional","affiliation":[{"name":"Faculty of Health and Wellbeing, Northumbria University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026090306262615000_16.6.e113676.1","unstructured":"Cancer Research UK . Breast cancer statistics 2015-2017. n.d. Available: https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/breast-cancer"},{"key":"2026090306262615000_16.6.e113676.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"2026090306262615000_16.6.e113676.3","doi-asserted-by":"publisher","DOI":"10.1007\/S10549-016-4090-7\/TABLES\/4"},{"key":"2026090306262615000_16.6.e113676.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00582-3"},{"key":"2026090306262615000_16.6.e113676.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08617-6"},{"key":"2026090306262615000_16.6.e113676.6","unstructured":"American College of Radiology . BI-RADS Atlas. 5th edn.2013. Available: https:\/\/www.acr.org\/Clinical-Resources\/Reporting-and-Data-Systems\/Bi-Rads"},{"key":"2026090306262615000_16.6.e113676.7","unstructured":"Society of Nuclear Medicine and Molecular Imaging . Molecular Breast Imaging Site Directory, 2022. Available: https:\/\/www.snmmi.org\/AboutSNMMI\/CommitteeContent.aspx?ItemNumber=35578"},{"key":"2026090306262615000_16.6.e113676.8","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-011-0544-5"},{"key":"2026090306262615000_16.6.e113676.9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13357"},{"key":"2026090306262615000_16.6.e113676.10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41416-024-02930-1","article-title":"Women\u2019s perspectives of molecular breast imaging: a qualitative study","volume":"132","author":"Elliott","year":"2025","journal-title":"Br J Cancer"},{"key":"2026090306262615000_16.6.e113676.11","doi-asserted-by":"publisher","DOI":"10.1177\/1049732315617444"},{"key":"2026090306262615000_16.6.e113676.12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/pgfar04110","article-title":"Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study","volume":"4","author":"Evans","year":"2016","journal-title":"Programme Grants Appl Res"},{"key":"2026090306262615000_16.6.e113676.13","unstructured":"National Institute for Health and Care Excellence . Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer. In: NICE Clinical Guidelines, No. 164. 2013. Available: https:\/\/www.nice.org.uk\/guidance\/cg164\/ifp\/chapter\/early-detection-of-breast-cancer-by-surveillance"},{"key":"2026090306262615000_16.6.e113676.14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/jbi\/wbad011","article-title":"Molecular Breast Imaging in the Screening Setting","volume":"5","author":"Smith","year":"2023","journal-title":"J Breast Imaging"},{"key":"2026090306262615000_16.6.e113676.15","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.243953","article-title":"Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial","volume":"316","author":"Hruska","year":"2025","journal-title":"Radiology"},{"key":"2026090306262615000_16.6.e113676.16","doi-asserted-by":"publisher","DOI":"10.1118\/1.4718665"},{"key":"2026090306262615000_16.6.e113676.17","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20170268","article-title":"Radioactive seed localization compared with wire-guided localization of non-palpable breast carcinoma in breast conservation surgery- the first experience in the United Kingdom","volume":"91","author":"Milligan","year":"2018","journal-title":"Br J Radiol"},{"key":"2026090306262615000_16.6.e113676.18","doi-asserted-by":"crossref","DOI":"10.1177\/21501327211058322","article-title":"Benefits and Risks of Mammography Screening in Women Ages 40 to 49\u2009Years","volume":"13","author":"Grimm","year":"2022","journal-title":"J Prim Care Community Health"},{"key":"2026090306262615000_16.6.e113676.19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.rcl.2020.09.005","article-title":"Overdiagnosis and Risks of Breast Cancer Screening","volume":"59","author":"Neal","year":"2021","journal-title":"Radiol Clin North Am"},{"key":"2026090306262615000_16.6.e113676.20","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2009.009094"},{"key":"2026090306262615000_16.6.e113676.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2020.03.006"},{"key":"2026090306262615000_16.6.e113676.22","unstructured":"NHS Digital . Breast screening programme,England 2021-22. n.d. Available: https:\/\/digital.nhs.uk\/data-and-information\/publications\/statistical\/breast-screening-programme\/england---2021-22"},{"key":"2026090306262615000_16.6.e113676.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9406(05)65462-4"},{"key":"2026090306262615000_16.6.e113676.24","unstructured":"NHS England . Report of the independent review of adult screening programmes. 2019. Available: https:\/\/www.england.nhs.uk\/publication\/terms-of-reference-review-national-cancer-screening-programmes-england"},{"key":"2026090306262615000_16.6.e113676.25","unstructured":"British Broadcasting Corporation . Breast screening error \u2019shortened up to 270 lives\u2019 - hunt. 2018."},{"key":"2026090306262615000_16.6.e113676.26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-067441","article-title":"Approaches to improving patient safety in integrated care: a scoping review","volume":"13","author":"Lalani","year":"2023","journal-title":"BMJ Open"},{"key":"2026090306262615000_16.6.e113676.27","doi-asserted-by":"publisher","DOI":"10.3310\/hsdr02300"},{"key":"2026090306262615000_16.6.e113676.28","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-019-4790-x","article-title":"Why does the NHS struggle to adopt eHealth innovations? A review of macro, meso and micro factors","volume":"19","author":"Asthana","year":"2019","journal-title":"BMC Health Serv Res"},{"key":"2026090306262615000_16.6.e113676.29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1108\/JHOM-02-2019-0031","article-title":"Creating the conditions for change: an NHS perspective","volume":"ahead-of-print","author":"Fitzgerald","year":"2019","journal-title":"J Health Organ Manag"},{"key":"2026090306262615000_16.6.e113676.30","unstructured":"Gilbert FJ . Breast screening - risk adaptive imaging for density (BRAID). 2020. Available: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04097366"},{"key":"2026090306262615000_16.6.e113676.31","unstructured":"UniCancer . MyPeBS, 2022. Available: https:\/\/www.mypebs.eu\/"},{"key":"2026090306262615000_16.6.e113676.32","unstructured":"Kings College Hospital NHS Foundation Trust . The prospects trial 2017. 2017. Available: https:\/\/medphys.royalsurrey.nhs.uk\/prospects\/"},{"key":"2026090306262615000_16.6.e113676.33","doi-asserted-by":"crossref","DOI":"10.1186\/s12919-024-00306-0","article-title":"Risk stratification in breast screening workshop","volume":"18","author":"Anderson","year":"2024","journal-title":"BMC Proc"},{"key":"2026090306262615000_16.6.e113676.34","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/eurpub\/ckab084","article-title":"Shared decision making in breast cancer screening guidelines: a systematic review of their quality and reporting","volume":"31","author":"Maes-Carballo","year":"2021","journal-title":"Eur J Public Health"},{"key":"2026090306262615000_16.6.e113676.35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6654.943"},{"key":"2026090306262615000_16.6.e113676.36","unstructured":"Patterson J , Stinton C , Alkhudairy L , et al . Additional screening with ultrasound after negative mammography screening in women with dense breasts: a systematic review prospero - crd420170812132019. 2019. Available: https:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?RecordID=81213"},{"key":"2026090306262615000_16.6.e113676.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.06.005"},{"key":"2026090306262615000_16.6.e113676.38","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3267"},{"key":"2026090306262615000_16.6.e113676.39","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1848-3"},{"key":"2026090306262615000_16.6.e113676.40","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13306"},{"key":"2026090306262615000_16.6.e113676.41","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000248"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-113676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:27:50Z","timestamp":1788442070000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-113676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,3]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bmjopen-2025-113676"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-113676","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}