{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:38:45Z","timestamp":1792798725322,"version":"4.5.0"},"reference-count":77,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Ottawa, Translational Research Grant","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"https:\/\/ror.org\/03c4mmv16","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of Ottawa Heart Institute ORACLE Innovation Fund","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"https:\/\/ror.org\/03c4mmv16","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,2,18]]},"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1136\/bmjopen-2025-114239","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:18:07Z","timestamp":1772810287000},"page":"e114239","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Vascular Inflammation In Patients with Community-Acquired Pneumonia (TIN-CAP): protocol for a multicentre, randomised, double-blind, placebo-controlled trial"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct06710080","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Cameron","family":"Stotts","sequence":"first","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"},{"name":"Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente F","family":"Corrales-Medina","sequence":"additional","affiliation":[{"name":"Centre for Infection, Immunity & Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada"},{"name":"Department of Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada"},{"name":"The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"deKemp","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2289-9139","authenticated-orcid":false,"given":"George A","family":"Wells","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Beanlands","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada"},{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Raggi","sequence":"additional","affiliation":[{"name":"Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada"},{"name":"University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ferrara","sequence":"additional","affiliation":[{"name":"University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-0401","authenticated-orcid":false,"given":"Wendy","family":"Sligl","sequence":"additional","affiliation":[{"name":"University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"A Connelly","sequence":"additional","affiliation":[{"name":"St Michaels Hospital Keenan Research Centre for Biomedical Science, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narinder","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Contreras-Dominguez","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-4634","authenticated-orcid":false,"given":"Krishan","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Acute Care Research Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Tavoosi","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Wiefels","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Kirpalani","sequence":"additional","affiliation":[{"name":"St Michaels Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G","family":"Romsa","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Division of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Grey","sequence":"additional","affiliation":[{"name":"St Michaels Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djeven","family":"Deva","sequence":"additional","affiliation":[{"name":"St Michaels Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katey","family":"Rayner","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-9372","authenticated-orcid":false,"given":"Kevin Emery","family":"Boczar","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"2026102004100469000_16.3.e114239.1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature New Biol"},{"key":"2026102004100469000_16.3.e114239.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"2026102004100469000_16.3.e114239.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.050"},{"key":"2026102004100469000_16.3.e114239.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67528-9"},{"key":"2026102004100469000_16.3.e114239.5","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-022-01542-4","article-title":"PCSK9 inhibitors for secondary prevention in patients with cardiovascular diseases: a bayesian network meta-analysis","volume":"21","author":"Wang","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"2026102004100469000_16.3.e114239.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"2026102004100469000_16.3.e114239.7","first-page":"1553","article-title":"Hearts on Fire: The Role of Inflammation in the Pathogenesis of Atherosclerotic Cardiovascular Disease and How We Can Tend to the Flames","volume":"38","author":"Boczar","year":"2022","journal-title":"Can J Cardiol"},{"key":"2026102004100469000_16.3.e114239.8","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9840-2"},{"key":"2026102004100469000_16.3.e114239.9","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz053"},{"key":"2026102004100469000_16.3.e114239.10","unstructured":"Statistics Canada . Leading causes of death, total population, by age group. 2022."},{"key":"2026102004100469000_16.3.e114239.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.040766"},{"key":"2026102004100469000_16.3.e114239.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.18229"},{"key":"2026102004100469000_16.3.e114239.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61266-5"},{"key":"2026102004100469000_16.3.e114239.14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.chest.2021.02.048","article-title":"Persistent Lung Inflammation After Clinical Resolution of Community-Acquired Pneumonia as Measured by 18FDG-PET\/CT Imaging","volume":"160","author":"Corrales-Medina","year":"2021","journal-title":"Chest"},{"key":"2026102004100469000_16.3.e114239.15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jcmg.2022.10.003","article-title":"Vascular Inflammation During and After Community-Acquired Pneumonia as Measured by 18F-FDG-PET\/CT Imaging","volume":"16","author":"Boczar","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026102004100469000_16.3.e114239.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"2026102004100469000_16.3.e114239.17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321636"},{"key":"2026102004100469000_16.3.e114239.18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15507-w","article-title":"Cardiovascular changes after pneumonia in a dual disease mouse model","volume":"12","author":"Bartlett","year":"2022","journal-title":"Sci Rep"},{"key":"2026102004100469000_16.3.e114239.19","unstructured":"Health, C. A. f. D. a. T. i. CADTH Canadian Drug Expert Committee Recommendation: Icosapent Ethyl (Vascepa  HLS Therapeutics Inc.) . Indication: Prevention of cardiovascular events in statin-treated patients. 2020."},{"key":"2026102004100469000_16.3.e114239.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.07.023"},{"key":"2026102004100469000_16.3.e114239.21","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112599","article-title":"Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"11","author":"Sekikawa","year":"2019","journal-title":"Nutrients"},{"key":"2026102004100469000_16.3.e114239.22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.amjmed.2020.07.022","article-title":"Major Lipids and Future Risk of Pneumonia: 20-Year Observation of the Atherosclerosis Risk in Communities (ARIC) Study Cohort","volume":"134","author":"Bae","year":"2021","journal-title":"Am J Med"},{"key":"2026102004100469000_16.3.e114239.23","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw147"},{"key":"2026102004100469000_16.3.e114239.24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.110.959478"},{"key":"2026102004100469000_16.3.e114239.25","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-011-9338-3"},{"key":"2026102004100469000_16.3.e114239.26","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23553"},{"key":"2026102004100469000_16.3.e114239.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.08.006"},{"key":"2026102004100469000_16.3.e114239.28","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.065151"},{"key":"2026102004100469000_16.3.e114239.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.088"},{"key":"2026102004100469000_16.3.e114239.30","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000138"},{"key":"2026102004100469000_16.3.e114239.31","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e7586","article-title":"SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials","volume":"346","author":"Chan","year":"2013","journal-title":"BMJ"},{"key":"2026102004100469000_16.3.e114239.32","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001303"},{"key":"2026102004100469000_16.3.e114239.33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500245"},{"key":"2026102004100469000_16.3.e114239.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.09.015"},{"key":"2026102004100469000_16.3.e114239.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.04.028"},{"key":"2026102004100469000_16.3.e114239.36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.88"},{"key":"2026102004100469000_16.3.e114239.37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701233360402"},{"key":"2026102004100469000_16.3.e114239.38","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.5.377"},{"key":"2026102004100469000_16.3.e114239.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.066"},{"key":"2026102004100469000_16.3.e114239.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.08.007"},{"key":"2026102004100469000_16.3.e114239.41","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ijcard.2018.05.057","article-title":"[18F]-Fluorodeoxyglucose PET\/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events","volume":"271","author":"Cocker","year":"2018","journal-title":"Int J Cardiol"},{"key":"2026102004100469000_16.3.e114239.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.05.024"},{"key":"2026102004100469000_16.3.e114239.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.10.009"},{"key":"2026102004100469000_16.3.e114239.44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"2026102004100469000_16.3.e114239.45","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7255.199"},{"key":"2026102004100469000_16.3.e114239.46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","article-title":"C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease)","volume":"99","author":"Koenig","year":"1984","journal-title":"Circulation"},{"key":"2026102004100469000_16.3.e114239.47","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.6.1121"},{"key":"2026102004100469000_16.3.e114239.48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"2026102004100469000_16.3.e114239.49","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.17.2107"},{"key":"2026102004100469000_16.3.e114239.50","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148135.08582.97"},{"key":"2026102004100469000_16.3.e114239.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.037"},{"key":"2026102004100469000_16.3.e114239.52","first-page":"179","article-title":"Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells","volume":"124","author":"Libby","year":"1986","journal-title":"Am J Pathol"},{"key":"2026102004100469000_16.3.e114239.53","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3800"},{"key":"2026102004100469000_16.3.e114239.54","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"2026102004100469000_16.3.e114239.55","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201400130"},{"key":"2026102004100469000_16.3.e114239.56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature New Biol"},{"key":"2026102004100469000_16.3.e114239.57","doi-asserted-by":"publisher","DOI":"10.1038\/89759"},{"key":"2026102004100469000_16.3.e114239.58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4939-7592-1_4","article-title":"Lipid Mediator Metabolomics Via LC-MS\/MS Profiling and Analysis","volume":"1730","author":"Dalli","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2026102004100469000_16.3.e114239.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.04.015"},{"key":"2026102004100469000_16.3.e114239.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.05.031"},{"key":"2026102004100469000_16.3.e114239.61","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300019-JLR200"},{"key":"2026102004100469000_16.3.e114239.62","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1007\/s12350-021-02830-4","article-title":"Anti-inflammatory effect of rosuvastatin in patients with HIV infection: An FDG-PET pilot study","volume":"29","author":"Boczar","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"2026102004100469000_16.3.e114239.63","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102497","article-title":"Protocol for density gradient neutrophil isolation and flow cytometry-based characterization from human peripheral blood","volume":"4","author":"Kuang","year":"2023","journal-title":"STAR Protoc"},{"key":"2026102004100469000_16.3.e114239.64","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"2026102004100469000_16.3.e114239.65","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-074463","article-title":"The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events, Evaluation of Colchicine Effectiveness (CADENCE): protocol for a randomised, double-blind, placebo-controlled trial","volume":"13","author":"Boczar","year":"2023","journal-title":"BMJ Open"},{"key":"2026102004100469000_16.3.e114239.66","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00259-015-3081-y","article-title":"F-FDG uptake in patients suffering from granulomatosis with polyangiitis","volume":"42","author":"Kemna","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2026102004100469000_16.3.e114239.67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"},{"key":"2026102004100469000_16.3.e114239.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.06.022"},{"key":"2026102004100469000_16.3.e114239.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.02.016"},{"key":"2026102004100469000_16.3.e114239.70","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61383-4"},{"key":"2026102004100469000_16.3.e114239.71","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.11061"},{"key":"2026102004100469000_16.3.e114239.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.03.039"},{"key":"2026102004100469000_16.3.e114239.73","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315878"},{"key":"2026102004100469000_16.3.e114239.74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206797"},{"key":"2026102004100469000_16.3.e114239.75","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cpdd.84","article-title":"Pharmacokinetics of Eicosapentaenoic Acid in Plasma and Red Blood Cells After Multiple Oral Dosing With Icosapent Ethyl in Healthy Subjects","volume":"3","author":"Braeckman","year":"2014","journal-title":"Clin Pharmacol Drug Dev"},{"key":"2026102004100469000_16.3.e114239.76","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.321001"},{"key":"2026102004100469000_16.3.e114239.77","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5847\/wjem.j.1920-8642.2025.098","article-title":"Long-term cardiovascular outcomes and risk factors in adult sepsis survivors: a systematic review and meta-analysis","volume":"16","author":"Wu","year":"2025","journal-title":"World J Emerg Med"}],"updated-by":[{"DOI":"10.1136\/bmjopen-2025-114239corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000}}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-114239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:00:10Z","timestamp":1792609210000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-114239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":77,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,4]]},"published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1136\/bmjopen-2025-114239"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-114239","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}