{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:55:52Z","timestamp":1782496552898,"version":"3.54.5"},"reference-count":15,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014555","name":"Murdoch Children\u2019s Research Institute","doi-asserted-by":"publisher","award":["Clinician-Scientist Fellowship"],"award-info":[{"award-number":["Clinician-Scientist Fellowship"]}],"id":[{"id":"10.13039\/100014555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2008911"],"award-info":[{"award-number":["GNT2008911"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,1,20]]},"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Approximately 6%\u201310% of adults carry food allergy labels. Many such labels are unverified and may be incorrect, contributing to delays in appropriate care, significant dietary restriction, anxiety and unnecessary use of emergency medications. Oral food challenges (OFCs) are the gold standard for confirming or excluding food allergy, but the current model of clinic-based challenges often has long wait times and logistical barriers. This study aims to investigate the feasibility and safety of home-based OFCs compared with standard in-clinic challenges in adults with negative skin-prick testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Food C<\/jats:bold>\n                      hallenge at\n                      <jats:bold>HO<\/jats:bold>\n                      me or in\n                      <jats:bold>M<\/jats:bold>\n                      edical\n                      <jats:bold>P<\/jats:bold>\n                      ractice is a pilot multicentre randomised controlled trial enrolling 120 adults with reported food allergy labels and negative skin prick testing to the implicated food. Participants will be randomised 1:1 to undergo an OFC either at home or in-clinic. The study is designed to generate feasibility and preliminary safety data for home-based OFC, measured by the proportion of participants experiencing immune-mediated adverse events (AEs), compared with clinic-based OFC. Feasibility metrics (screening to recruitment ratio, protocol completion), non-immune AEs, protocol adherence and quality of life assessed using the Food Allergy Quality of Life Questionnaire-12 at baseline prior to OFC and 6\u2009months post OFC will also be collected. Statistical analysis will include descriptive statistics, with comparisons between arms using risk differences and relative risks with 95% CIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The trial has received ethics approval from the Austin Health Human Research Ethics Committee (HREC\/111750\/Austin-2024). Findings will be disseminated through peer-reviewed publications and scientific meetings. Data will be presented in aggregated, de-identified form.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06916819\">NCT06916819<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-114483","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T14:56:09Z","timestamp":1770389769000},"page":"e114483","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["FoodCHOMP (Food Challenge\u2014at HOme or in Medical Practice): a pilot multicentre randomised controlled trial evaluating home versus clinic-based food allergy challenges in low-risk adults\u2013study protocol"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct06916819","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06916819","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8768-2385","authenticated-orcid":false,"given":"Jack","family":"Godsell","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"},{"name":"Department of Clinical Immunology and Allergy, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Vogrin","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Clinical Immunology and Allergy, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Henri","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-4666","authenticated-orcid":false,"given":"Irvin","family":"Ng","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-0334","authenticated-orcid":false,"given":"Kymble","family":"Spriggs","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"},{"name":"Department of Allergy and Immunology, Monash Health, Clayton, Victoria, Australia"},{"name":"National Allergy Centre of Excellence (NACE), Melbourne, Victoria, Australia"},{"name":"Department of Medicine, The University of Melbourne Department of Medicine Royal Melbourne Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-996X","authenticated-orcid":false,"given":"Kirsten P","family":"Perrett","sequence":"additional","affiliation":[{"name":"National Allergy Centre of Excellence (NACE), Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Murdoch Childrens Research Institute, Parkville, Victoria, Australia"},{"name":"Department of Allergy and Immunology, The Royal Children\u2019s Hospital Melbourne, Parkville, Victoria, Australia"},{"name":"The University of Melbourne Department of Paediatrics, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-6367","authenticated-orcid":false,"given":"Jason","family":"Trubiano","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026062610411974000_16.2.e114483.1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.5630","article-title":"Prevalence and Severity of Food Allergies Among US Adults","volume":"2","author":"Gupta","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2026062610411974000_16.2.e114483.2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13362"},{"key":"2026062610411974000_16.2.e114483.3","doi-asserted-by":"crossref","DOI":"10.1186\/s12948-016-0041-4","article-title":"Quality of life in patients with food allergy","volume":"14","author":"Antol\u00edn-Am\u00e9rigo","year":"2016","journal-title":"Clin Mol Allergy"},{"key":"2026062610411974000_16.2.e114483.4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.anai.2016.02.016","article-title":"The economic effect and outcome of delaying oral 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