{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:54Z","timestamp":1792787274030,"version":"4.5.0"},"reference-count":35,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["No.82401845, PI: MLG"],"award-info":[{"award-number":["No.82401845, PI: MLG"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University","award":["Z2024JC005, PI: CYF"],"award-info":[{"award-number":["Z2024JC005, PI: CYF"]}]},{"name":"the clinical application study of digital flow fluorescence detection technology in early screening of Alzheimer\u2019s disease","award":["311250302, PI:XLD"],"award-info":[{"award-number":["311250302, PI:XLD"]}]},{"name":"the National Key Research and Development Program of China","award":["2023YFC3605900\/02"],"award-info":[{"award-number":["2023YFC3605900\/02"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,9,11]]},"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between peripheral platelet indices and motoric cognitive risk syndrome (MCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional analysis using baseline data from the West China Health and Aging Trend (WCHAT) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Community settings across several ethnically diverse regions of western China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>From an initial pool of 7536 community-dwelling adults in the WCHAT study, 4080 participants were included in the final analysis after applying exclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>The primary outcome was MCR, defined by the concurrent presence of subjective cognitive complaints and slow gait speed (\u22651 SD below sex- and age-stratified mean) in the absence of dementia or mobility disability. The exposures were platelet indices, including platelet count (PLT), mean platelet volume, platelet distribution width (PDW), platelet-large cell ratio (P-LCR) and platelet crit (PCT). Multivariable logistic regression was used to examine the associations between platelet indices and MCR. Restricted cubic spline analysis was performed to explore non-linear associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 4080 participants, 320 (7.84%) met the diagnostic criteria for MCR. After adjustment for potential confounders, higher PLT (OR=1.17, 95%\u2009CI 1.04 to 1.32, p=0.007) and PCT (OR=1.13, 95%\u2009CI 1.01 to 1.26, p=0.046) were associated with greater odds of MCR. Conversely, higher PDW (OR=0.85, 95%\u2009CI 0.75 to 0.97, p=0.014) and P-LCR (OR=0.87, 95%\u2009CI 0.77 to 0.98, p=0.026) were associated with lower odds of MCR. Furthermore, a nonlinear relationship was identified for PDW and MCR (p&lt;0.05), with a threshold at 13.40%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Specific platelet indices are significantly associated with MCR. Further prospective studies are warranted to confirm these associations and explore the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>China Clinical Trial Center (ChiCTR1800018895).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-115160","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:41:47Z","timestamp":1790862107000},"page":"e115160","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association between peripheral platelet markers and motoric cognitive risk syndrome: a cross-sectional analysis of data from the WCHAT study"],"prefix":"10.1136","volume":"16","author":[{"given":"Fengjuan","family":"Hu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Geriatrics, Center of 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