{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:49:51Z","timestamp":1785761391246,"version":"3.56.0"},"reference-count":60,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NWO, Regieorgaan SIA","award":["RAAK.MKB21.010"],"award-info":[{"award-number":["RAAK.MKB21.010"]}]},{"name":"Institute of Movement Studies","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Utrecht University of Applied Sciences","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,7,10]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify clinical indicators reflecting potentially treatment-modifiable prognostic factors associated with pain recovery in patients with non-specific neck pain and to develop a prototype clinical compass for visualising patient-specific profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Secondary analysis of data from a multicentre, prospective, observational prognostic cohort study, with a 6-month follow-up between January 2020 and March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>30 physiotherapy primary care practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with a new episode of non-specific neck pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Patients completed questionnaires at baseline, 6\u2009weeks, 3\u2009months and 6\u2009months assessing pain intensity and biological, psychological and social factors. Questionnaire total scores and individual items reflecting selected potentially modifiable factors were tested separately as candidate indicators. Baseline and repeated indicators were examined as effect modifiers of pain trajectories using growth-curve models. Subsequently, modifiable clinical indicators were incorporated as effect modifiers to evaluate their influence on the trajectory of pain intensity over time. Non-redundant significant indicators were integrated into a prototype clinical compass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 603 participants were collected. A quadratic growth-curve model best explained the longitudinal change of pain intensity. 24 clinical indicators were significantly associated with the trajectory of pain intensity over time. Two characteristics were excluded as they demonstrated high intercorrelation. Based on these findings, a clinical compass comprising 22 clinical indicators was developed to visualise patient-specific profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides a prototype clinical compass that may inform prognostic reasoning in primary care physiotherapy, but further evaluation is needed before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-115274","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:05:55Z","timestamp":1785758755000},"page":"e115274","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical indicators associated with pain trajectories in non-specific neck pain: a secondary analysis of a multicentre prospective observational cohort to develop a clinical compass for personalised physiotherapy in primary care"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-9235","authenticated-orcid":false,"given":"Martine J","family":"Verwoerd","sequence":"first","affiliation":[{"name":"Research Group Clinical Decision Making in Movement Care, Utrecht University of Applied Sciences, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A W","family":"Felius","sequence":"additional","affiliation":[{"name":"Research Group Clinical Decision Making in Movement Care, Utrecht University of Applied Sciences, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Konings","sequence":"additional","affiliation":[{"name":"Research Group Clinical Decision Making in Movement Care, Utrecht University of Applied Sciences, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Kiers","sequence":"additional","affiliation":[{"name":"Research Group Clinical Decision Making in Movement Care, Utrecht University of Applied Sciences, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J E M","family":"Smeets","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands"},{"name":"CIR Clinics in Revalidatie, Eindhoven, Netherlands"},{"name":"Pain in Motion International Research Group, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026080305052449000_16.8.e115274.1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.33393\/aop.2024.3245","article-title":"Red flags for potential serious pathologies in people with neck pain: a systematic review of clinical practice guidelines","volume":"14","author":"Feller","year":"2024","journal-title":"Arch Physiother"},{"key":"2026080305052449000_16.8.e115274.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00268-1"},{"key":"2026080305052449000_16.8.e115274.3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00586-008-0627-8","article-title":"Course and Prognostic Factors for Neck Pain in the General Population","volume":"17","author":"Carroll","year":"2008","journal-title":"Eur Spine J"},{"key":"2026080305052449000_16.8.e115274.4","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000146"},{"key":"2026080305052449000_16.8.e115274.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-016-4467-7"},{"key":"2026080305052449000_16.8.e115274.6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bjpt.2017.05.005","article-title":"Prevalence and factors associated with neck pain: a population-based study","volume":"21","author":"Genebra","year":"2017","journal-title":"Braz J Phys Ther"},{"key":"2026080305052449000_16.8.e115274.7","doi-asserted-by":"crossref","first-page":"e591","DOI":"10.1016\/S2665-9913(22)00159-X","article-title":"Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial","volume":"4","author":"Hill","year":"2022","journal-title":"Lancet Rheumatol"},{"key":"2026080305052449000_16.8.e115274.8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/ejp.2091","article-title":"Personalized pain management: Is it time for process\u2010based therapy for particular people with chronic pain?","volume":"27","author":"McCracken","year":"2023","journal-title":"European Journal of Pain"},{"key":"2026080305052449000_16.8.e115274.9","doi-asserted-by":"crossref","unstructured":"McCracken LM , Turk DC . 2002 Behavioral and Cognitive\u2013Behavioral Treatment for Chronic Pain. 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