{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:08:05Z","timestamp":1779890885197,"version":"3.53.1"},"reference-count":20,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460135"],"award-info":[{"award-number":["82460135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L248074"],"award-info":[{"award-number":["L248074"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0918504"],"award-info":[{"award-number":["2024YFA0918504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2024-RW320-01"],"award-info":[{"award-number":["2024-RW320-01"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,5,15]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Recurrence of acute pancreatitis (AP) is common, leading to cumulative pancreatic injury and reduced quality of life. While aetiology-based treatments and lifestyle interventions are effective, long-term adherence is often poor due to insufficient health awareness and a lack of continuous reminders. We designed the PROGRESS (\n                      <jats:italic>PRO<\/jats:italic>\n                      active\n                      <jats:italic>GR<\/jats:italic>\n                      ad\n                      <jats:italic>E<\/jats:italic>\n                      d follow-up\n                      <jats:italic>S<\/jats:italic>\n                      trategy for reducing recurrence in acute pancreatiti\n                      <jats:italic>S<\/jats:italic>\n                      ) trial to evaluate whether a physician-initiated, proactive and graded follow-up strategy can reduce AP recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The PROGRESS trial is a multicentre, open-label, randomised controlled trial. A total of 194 patients with AP will be randomised 1:1 to either a proactive follow-up group or a standard follow-up group. In the proactive follow-up group, patients are stratified into high-risk or low-risk categories based on reported risk factors. Follow-up is conducted via WeChat with varying frequencies: every 3 months for the high-risk group and every 6 months for the low-risk group. The standard follow-up group receives routine discharge education and a 1-month outpatient visit. The primary endpoint is the number of AP recurrence episodes within 24 months post-discharge. Secondary endpoints include AP recurrence rate, progression to chronic pancreatitis, quality of life (Short Form 12 Health Survey), anxiety\/depression scores (Generalized Anxiety Disorder-7\/Patient Health Questionnaire-9), readmission rates and mortality. Analysis will follow the intention-to-treat principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved by the Ethics Committee of Peking Union Medical College Hospital (No. I-25PJ2556, I-26PJ0895). Ethics approval of each participating centre is required before initiation of patient enrolment. The results of this study will be published in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ChiCTR2500113459 (Chinese Clinical Trial Registry).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-117540","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:00:55Z","timestamp":1779883255000},"page":"e117540","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Proactive graded follow-up strategy for reducing recurrence in acute pancreatitis (PROGRESS): protocol for a multicentre, randomised controlled trial"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6817-1219","authenticated-orcid":false,"given":"Yingyu","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-9003","authenticated-orcid":false,"given":"Yuelun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"2026052706302432000_16.5.e117540.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0087-5"},{"key":"2026052706302432000_16.5.e117540.2","doi-asserted-by":"crossref","first-page":"17562848241255303","DOI":"10.1177\/17562848241255303","article-title":"Incidence of recurrent and chronic pancreatitis after acute pancreatitis: a systematic review and meta-analysis","volume":"17","author":"Gagyi","year":"2024","journal-title":"Therap Adv Gastroenterol"},{"key":"2026052706302432000_16.5.e117540.3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41395-018-0087-7","article-title":"Recurrent Acute Pancreatitis 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