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MetS components, diabetes-related complications and LUTS severity were compared between men with and without ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 305 men with urinary urgency, 181 (59%) had ED. Men with ED were significantly older and more likely to have type 2 diabetes (25% vs 12%, p&lt;0.01). Peripheral neuropathy (38% vs 25%, p=0.02) and autonomic neuropathy (57% vs 43%, p=0.02) were more common in men with ED. The majority of men without ED correspondingly did not report MetS components. Finally, men with ED reported more severe LUTS, including higher total LUTS scores and a greater burden of storage symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest that diabetes as well as markers of metabolic dysfunction are important factors in ED in treatment-seeking men with urinary urgency and other LUTS. Studies evaluating the mechanisms contributing to these interactions are warranted for targeting effective prevention or treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-118422","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:58Z","timestamp":1787237158000},"page":"e118422","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Erectile dysfunction and its associations with type 2 diabetes, neuropathy, metabolic syndrome in men seeking specialty care for urinary urgency: a cross-sectional study"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct04557748","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-3888","authenticated-orcid":false,"given":"Harini V","family":"Pennathur","sequence":"first","affiliation":[{"name":"Engineering Medicine, Texas A&M 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