{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:00:39Z","timestamp":1784833239892,"version":"3.55.0"},"reference-count":34,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10390172310017"],"award-info":[{"award-number":["10390172310017"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,6,8]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Dutch guideline \u2018Gallstone disease\u2019 (2016) recommends performing a cholecystectomy within 72 hours following endoscopic retrograde cholangiopancreatography (ERCP) for common bile duct stones to prevent recurrent gallstone-related complications. Nevertheless, guideline adherence in the Netherlands remains low, and the time between ERCP and cholecystectomy often exceeds 72 hours. Our project aims to improve national guideline adherence to 85% or higher and thereby reduce the incidence of gallstone-related complications after ERCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The Dutch-TIMELINESS is a multicentre implementation project using a Multiphase Optimisation Strategy. The project includes 61 Dutch hospitals. In phase 1, all patients undergoing ERCP for choledocholithiasis from 1 January to 31 March 2023 will be analysed to serve as a benchmark. In phase 2, each hospital develops and implements its own tailored protocol in line with the guideline, guided by the benchmark data. In phase 3, from 1 December 2025 to 31 March 2026, the new protocols will be prospectively evaluated with real-time monitoring and refined as necessary. Statistical methods are predefined in the protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The Medical Research Ethics Committees United reviewed the protocol and concluded it does not fall under the scope of the Medical Research Involving Human Subjects Act (WMO). Local institutional research departments and the board of directors reviewed and approved the protocol in all participating hospitals. Results will be published in international peer-reviewed scientific journals and presented at national conferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-118615","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:05:23Z","timestamp":1784829923000},"page":"e118615","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Dutch-TIMELINESS: optimising choledocholithiasis treatment in the Netherlands \u2013 protocol of a national implementation project"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5231-2256","authenticated-orcid":false,"given":"Anne J J","family":"The","sequence":"first","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud M T","family":"Merks","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Goense","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6731-7205","authenticated-orcid":false,"given":"Max H G","family":"van Maasakkers","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"van der Schaar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van Duijvendijk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gelre Ziekenhuizen, Apeldoorn, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels G","family":"Venneman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Medisch Spectrum Twente, Enschede, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike S L","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medisch Spectrum Twente, Enschede, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P","family":"Deroose","sequence":"additional","affiliation":[{"name":"Department of Surgery, Martini Hospital, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J","family":"Thijs","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Martini Hospital, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-1390","authenticated-orcid":false,"given":"Lea M","family":"Dijksman","sequence":"additional","affiliation":[{"name":"Department of Research and Development, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Boerma","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teus J","family":"Weijs","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026072311051254000_16.7.e118615.1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.surg.2023.06.010","article-title":"Persistent and new-onset symptoms after cholecystectomy in patients with uncomplicated symptomatic cholecystolithiasis: A post hoc analysis of 2 prospective clinical trials","volume":"174","author":"Thunnissen","year":"2023","journal-title":"Surgery"},{"key":"2026072311051254000_16.7.e118615.2","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1097\/HEP.0000000000000264","article-title":"Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US","volume":"77","author":"Unalp-Arida","year":"2023","journal-title":"Hepatology"},{"key":"2026072311051254000_16.7.e118615.3","unstructured":"McNicoll CF , Pastorino A , Farooq U , et al . 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