{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:14:28Z","timestamp":1788444868753,"version":"build-2803163510"},"reference-count":60,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"unspecified","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taipei City, Taiwan, R.O.C.","award":["NSTC 112-2314-B-227 -008 -MY3"],"award-info":[{"award-number":["NSTC 112-2314-B-227 -008 -MY3"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,6,10]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The diagnosis and treatment of prostate cancer often disrupt patients\u2019 and their spouses\u2019 established family lives, requiring them to reestablish a sense of balance. This study aims to develop and evaluate a dyadic co-learning intervention derived from the activation-reinforcement-adjustment theory of family resilience for patients with prostate cancer and their spouses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      An experimental study design was employed. Prostate cancer patients and their spouses (n=60 pairs) will be recruited from the outpatient department. Following baseline assessment, participants will be randomly assigned to either the intervention group or the control group (1:1). The intervention group receives an 8\u2009week dyadic co-learning intervention and usual care, whereas the control group receives usual care. All participants complete follow-up assessments at 10 weeks and 16 weeks after the pretest. Structured questionnaires included the Resilience Scale, the Walsh Family Resilience Questionnaire, the Loneliness Scale, the Chinese Happiness Inventory, the Brief Fatigue Inventory and the Expanded Prostate Cancer Index Composite. Statistical analyses include independent-samples\n                      <jats:italic>t<\/jats:italic>\n                      tests, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests and mixed linear models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study protocol was approved by the Chang Gung Medical Foundation Institutional Review Board (No. 202\u2009202\u2009198B0). The study findings will be disseminated through international conferences and publication in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov ID:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\" xlink:href=\"NCT07196488\">NCT07196488<\/jats:ext-link>\n                      (First Submitted 2025-09-06).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-118902","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T11:25:44Z","timestamp":1782645944000},"page":"e118902","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Theory-based dyadic co-learning intervention to enhance family resilience in men with prostate cancer and their spouses in Taiwan: protocol for a randomised controlled trial"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct07196488","registry":"10.18810\/clinical-trials-gov","type":"results"},{"clinical-trial-number":"nct07196488","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-9934","authenticated-orcid":false,"given":"Ching-Hui","family":"Chien","sequence":"first","affiliation":[{"name":"School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Keng","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan"},{"name":"School of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Te","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan"},{"name":"Division of Urology, Department of Surgery, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See-Tong","family":"Pang","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan"},{"name":"School of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Jei","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan"},{"name":"School of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan"},{"name":"School of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-3938","authenticated-orcid":false,"given":"Kuan-Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"2026090306273132000_16.6.e118902.1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21834"},{"key":"2026090306273132000_16.6.e118902.2","unstructured":"Health Promotion Administration, Ministry of Health and Welfare . 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