{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:28:17Z","timestamp":1787239697232,"version":"build-2736575974"},"reference-count":63,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"unspecified","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["CRC-2019-00019"],"award-info":[{"award-number":["CRC-2019-00019"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Toronto Rehabilitation Institute Student Scholarship"},{"name":"Unity Health Toronto Endowed Chair in Homelessness, Housing"},{"name":"the Margaret & Howard Gamble Research Grant"},{"name":"Peterborough K.M. Hunter Charitable Foundation Graduate Awards"},{"name":"KITE\u2013Toronto Rehab\u2019s TD Graduate Scholarship, established with the generous support of the TD Bank Financial Group"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,8,3]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Depression is a prevalent mental health condition often occurring after traumatic brain injury (TBI) in both children and adults. Sex, gender and other social determinants of health (SDoH) (e.g., race\/ethnicity or socio-economic status) play an important role in depression-related and TBI-related healthcare utilisation (e.g., diagnosis, treatment and management of the conditions). Despite this, no reviews have examined how sex and gender, along with other SDoH, influence depression-related healthcare utilisation among individuals who sustained a TBI \u226419 years of age. The review\u2019s objective will be to synthesise evidence on sex-based and\/or gender-based findings, along with other SDoH, in depression-related healthcare utilisation among individuals who sustained a TBI \u226419 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Searches will be conducted on Ovid Medline, Embase, American Psychological Association PsycINFO and Cumulative Index of Nursing and Allied Health Literature from database inception to the search date. The review will follow the Joanna Briggs Institute evidence synthesis framework for knowledge synthesis and the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA)-P, PRISMA-Equity guidelines and PROGRESS-Plus for reporting results. Included studies will be peer-reviewed articles published in any language that examined individuals who sustained a TBI at \u226419 years of age, reported depression-related healthcare services and provided sex-stratified and\/or gender-stratified results. Studies will be excluded if they were grey literature, included individuals who sustained a TBI at &gt;19 years without age-stratified results, reported healthcare services for conditions other than depression without depression-specific stratification or did not provide sex-stratified or gender-stratified results. A narrative synthesis will be conducted to identify themes and attributes describing how sex, gender and other SDoH influence depression-related healthcare utilisation. Methodological quality will be assessed using the National Heart, Lung and Blood Institute Quality Assessment Tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>No institutional ethics approval will be required as this study will not conduct primary data collection. The review will be disseminated as a peer-reviewed publication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD420261301669.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-118951","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:45:46Z","timestamp":1787237146000},"page":"e118951","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of sex and gender on depression-related healthcare utilisation following traumatic brain injury sustained during childhood and adolescence: protocol for a systematic review"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6808-5936","authenticated-orcid":false,"given":"Cindy","family":"Nguyen","sequence":"first","affiliation":[{"name":"Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Occupational Science & Occupational Therapy (OS&OT), Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Faculty of Arts and Science, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Scandiffio","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"St. Michael\u2019s Hospital, Unity Health Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lewczuk","sequence":"additional","affiliation":[{"name":"KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada"},{"name":"Department of Occupational Science & Occupational Therapy (OS&OT), Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Faculty of Arts and Science, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora I","family":"Matheson","sequence":"additional","affiliation":[{"name":"MAP Centre for Urban Health Solutions, St. Michael\u2019s Hospital, Unity Health Toronto, Toronto, Ontario, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Colantonio","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada"},{"name":"Department of Occupational Science & Occupational Therapy (OS&OT), Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-044X","authenticated-orcid":false,"given":"Vincy","family":"Chan","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"2026082007453362000_16.8.e118951.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.05.017"},{"key":"2026082007453362000_16.8.e118951.2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/jamapediatrics.2018.2740","article-title":"Prevalence of Parent-Reported Traumatic Brain Injury in Children and Associated Health Conditions","volume":"172","author":"Haarbauer-Krupa","year":"2018","journal-title":"JAMA Pediatr"},{"key":"2026082007453362000_16.8.e118951.3","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1358"},{"key":"2026082007453362000_16.8.e118951.4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273072","article-title":"Social determinants of health associated with psychological distress stratified by lifetime traumatic brain injury status and sex: Cross-sectional evidence from a population sample of adults in Ontario, Canada","volume":"17","author":"Chan","year":"2022","journal-title":"PLoS One"},{"key":"2026082007453362000_16.8.e118951.5","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.24076","article-title":"Diagnostic Accuracy of Mental Health Screening Tools After Mild Traumatic Brain Injury","volume":"7","author":"Gitaari","year":"2024","journal-title":"JAMA Netw Open"},{"key":"2026082007453362000_16.8.e118951.6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/JSM.0000000000001110","article-title":"Influence of Mild Traumatic Brain Injury History and Mental Health Status on Alcohol and Cannabis Use in University Athletes","volume":"33","author":"Wilson","year":"2023","journal-title":"Clin J Sport Med"},{"key":"2026082007453362000_16.8.e118951.7","doi-asserted-by":"publisher","DOI":"10.1080\/026990501300005659"},{"key":"2026082007453362000_16.8.e118951.8","first-page":"3","volume-title":"Handbook of clinical neurology","volume":"127","author":"Faul","year":"2015"},{"key":"2026082007453362000_16.8.e118951.9","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1562"},{"key":"2026082007453362000_16.8.e118951.10","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4252"},{"key":"2026082007453362000_16.8.e118951.11","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.1091"},{"key":"2026082007453362000_16.8.e118951.12","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1089\/neu.2019.6957","article-title":"Treatment of Depression after Traumatic Brain Injury Reduces Risk of Neuropsychiatric Outcomes","volume":"37","author":"Albrecht","year":"2020","journal-title":"J Neurotrauma"},{"key":"2026082007453362000_16.8.e118951.13","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1089\/neu.2015.4349","article-title":"Depression Trajectories during the First Year after Traumatic Brain Injury","volume":"33","author":"Bombardier","year":"2016","journal-title":"J Neurotrauma"},{"key":"2026082007453362000_16.8.e118951.14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijdevneu.2011.12.005","article-title":"Depression in children and adolescents in the first 6 months after traumatic brain injury","volume":"30","author":"Max","year":"2012","journal-title":"Intl J Devlp Neuroscience"},{"key":"2026082007453362000_16.8.e118951.15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.599"},{"key":"2026082007453362000_16.8.e118951.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.10.006"},{"key":"2026082007453362000_16.8.e118951.17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/sjop.12587","article-title":"Prevalence of depression after moderate to severe traumatic brain injury among adolescents and young adults: A systematic review","volume":"61","author":"Ryttersgaard","year":"2020","journal-title":"Scandinavian J Psychology"},{"key":"2026082007453362000_16.8.e118951.18","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.1235","article-title":"Risk of Mental Health Problems in Children and Youths Following Concussion","volume":"5","author":"Ledoux","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2026082007453362000_16.8.e118951.19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.acap.2023.04.010","article-title":"Patterns and Predictors of Health Care Utilization After Pediatric Concussion: A Retrospective Cohort Study","volume":"24","author":"Meyer","year":"2024","journal-title":"Acad Pediatr"},{"key":"2026082007453362000_16.8.e118951.20","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.1097\/HTR.0000000000000343","article-title":"Depression and Depressive Symptoms in Pediatric Traumatic Brain Injury: A Scoping Review","volume":"33","author":"Lalibert\u00e9 Durish","year":"2018","journal-title":"J Head Trauma Rehabil"},{"key":"2026082007453362000_16.8.e118951.21","doi-asserted-by":"crossref","first-page":"15594","DOI":"10.3390\/ijerph121215009","article-title":"Socio Economic Status and Traumatic Brain Injury amongst Pediatric Populations: A Spatial Analysis in Greater Vancouver","volume":"12","author":"Amram","year":"2015","journal-title":"Int J Environ Res Public Health"},{"key":"2026082007453362000_16.8.e118951.22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/HTR.0b013e3182114efd","article-title":"Association of depressive symptoms with functional outcome after traumatic brain injury","volume":"PubMed Central PMCID","author":"Hudak","year":"2012","journal-title":"J Head Trauma Rehabil"},{"key":"2026082007453362000_16.8.e118951.23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3389\/fpsyg.2017.00634","article-title":"Depression in Men and Women One Year Following Traumatic Brain Injury (TBI): A TBI Model Systems Study","volume":"8","author":"Lavoie","year":"2017","journal-title":"Front Psychol"},{"key":"2026082007453362000_16.8.e118951.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2024.08.039"},{"key":"2026082007453362000_16.8.e118951.25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094936","article-title":"Suicidality, bullying and other conduct and mental health correlates of traumatic brain injury in adolescents","volume":"9","author":"Ilie","year":"2014","journal-title":"PLoS One"},{"key":"2026082007453362000_16.8.e118951.26","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.pmrj.2013.08.589","article-title":"Behavioral Predictors of Outpatient Mental Health Service Utilization Within 6 Months After Traumatic Brain Injury in Adolescents","volume":"5","author":"Kurowski","year":"2013","journal-title":"PM&R"},{"key":"2026082007453362000_16.8.e118951.27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s40141-019-00238-3","article-title":"Biological Sex\/Gender and Biopsychosocial Determinants of Traumatic Brain Injury Recovery Trajectories","volume":"7","author":"Niemeier","year":"2019","journal-title":"Curr Phys Med Rehabil Rep"},{"key":"2026082007453362000_16.8.e118951.28","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2018.3820","article-title":"Natural Progression of Symptom Change and Recovery From Concussion in a Pediatric Population","volume":"173","author":"Ledoux","year":"2019","journal-title":"JAMA Pediatr"},{"key":"2026082007453362000_16.8.e118951.29","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.183024"},{"key":"2026082007453362000_16.8.e118951.30","doi-asserted-by":"crossref","first-page":"105613","DOI":"10.1016\/j.nbd.2022.105613","article-title":"Traumatic brain injury in women across lifespan","volume":"164","author":"Blaya","year":"2022","journal-title":"Neurobiol Dis"},{"key":"2026082007453362000_16.8.e118951.31","doi-asserted-by":"crossref","first-page":"576366","DOI":"10.3389\/fneur.2021.576366","article-title":"Considering Biological Sex in Traumatic Brain Injury","volume":"12","author":"Biegon","year":"2021","journal-title":"Front Neurol"},{"key":"2026082007453362000_16.8.e118951.32","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6171"},{"key":"2026082007453362000_16.8.e118951.33","doi-asserted-by":"crossref","first-page":"678971","DOI":"10.3389\/fneur.2021.678971","article-title":"Systematic Review of Sex and Gender Effects in Traumatic Brain Injury: Equity in Clinical and Functional Outcomes","volume":"12","author":"Mollayeva","year":"2021","journal-title":"Front Neurol"},{"key":"2026082007453362000_16.8.e118951.34","doi-asserted-by":"crossref","first-page":"105952","DOI":"10.1016\/j.neubiorev.2024.105952","article-title":"The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis","volume":"168","author":"Sandhu","year":"2025","journal-title":"Neurosci Biobehav Rev"},{"key":"2026082007453362000_16.8.e118951.35","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2013.812240"},{"key":"2026082007453362000_16.8.e118951.36","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716643741"},{"key":"2026082007453362000_16.8.e118951.37","doi-asserted-by":"crossref","DOI":"10.1186\/s41073-016-0007-6","article-title":"Sex and Gender Equity in Research: rationale for the SAGER guidelines and recommended use","volume":"1","author":"Heidari","year":"2016","journal-title":"Res Integr Peer Rev"},{"key":"2026082007453362000_16.8.e118951.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2023.09.017"},{"key":"2026082007453362000_16.8.e118951.39","unstructured":"Government of Canada . Sex- and gender-based analysis plus in action at health Canada. 2024. Available: https:\/\/www.canada.ca\/en\/health-canada\/corporate\/transparency\/sex-gender-based-analysis-action.html"},{"key":"2026082007453362000_16.8.e118951.40","unstructured":"Canadian Institutes of Health Research (CIHR). Government of Canada . Gender-based analysis plus (GBA+) at CIHR. 2019. Available: https:\/\/cihr-irsc.gc.ca\/e\/50968.html"},{"key":"2026082007453362000_16.8.e118951.41","unstructured":"Greaves L , Poole N , Hemsing N , et al . Integrating sex and gender informed evidence into your practices: ten key questions on sex, gender & substance use. Centre of Excellence for Women\u2019s Health; 2020."},{"key":"2026082007453362000_16.8.e118951.42","unstructured":"Public Health Agency of Canada . How to integrate intersectionality theory in quantitative health equity analysis? A rapid review and checklist of promising practices. PHAC, 2022."},{"key":"2026082007453362000_16.8.e118951.43","unstructured":"Centre of Excellence for Women\u2019s Health . Advancing policy and research. n.d. Available: https:\/\/cewh.ca\/recent-work\/advancing-policy-and-research\/"},{"key":"2026082007453362000_16.8.e118951.44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001333","article-title":"PRISMA-Equity 2012 extension: reporting guidelines for systematic reviews with a focus on health equity","volume":"9","author":"Welch","year":"2012","journal-title":"PLoS Med"},{"key":"2026082007453362000_16.8.e118951.45","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2026082007453362000_16.8.e118951.46","doi-asserted-by":"crossref","unstructured":"Pearson A , Jordan Z , McArthur A , et al . Systematic reviews of textual evidence: narrative, expert opinion or policy. In: Aromataris E , Lockwood C , Porritt K , et al , eds. JBI manual for evidence synthesis. JBI, 2024. Available: https:\/\/jbi-global-wiki.refined.site\/space\/MANUAL\/355861531\/5.+Systematic+reviews+of+textual+evidence%3A+narrative%2C+expert+opinion+or+policy","DOI":"10.46658\/JBIMES-24-04"},{"key":"2026082007453362000_16.8.e118951.47","doi-asserted-by":"crossref","unstructured":"Page MJ , Moher D , Bossuyt PM , et al . PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ 2021;n160. doi:10.1136\/bmj.n160","DOI":"10.1136\/bmj.n160"},{"key":"2026082007453362000_16.8.e118951.48","unstructured":"Medical College of Wisconsin Libraries . Evidence based medicine. PICO. n.d. Available: https:\/\/mcw.libguides.com\/EBM\/PICO"},{"key":"2026082007453362000_16.8.e118951.49","article-title":"Prognostic models for predicting relapse or recurrence of major depressive disorder in adults","volume":"5","author":"Moriarty","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"2026082007453362000_16.8.e118951.50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264116","article-title":"A systematic review on integrated care for traumatic brain injury, mental health, and substance use","volume":"17","author":"Chan","year":"2022","journal-title":"PLoS ONE"},{"key":"2026082007453362000_16.8.e118951.51","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2023-107328"},{"key":"2026082007453362000_16.8.e118951.52","article-title":"Consumer-providers of care for adult clients of statutory mental health services","volume":"2013","author":"Pitt","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2026082007453362000_16.8.e118951.53","article-title":"Hypothermia for traumatic brain injury","volume":"9","author":"Lewis","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2026082007453362000_16.8.e118951.54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269696","article-title":"Protocol for a scoping review on rehabilitation among individuals with traumatic brain injury who intersect with the criminal justice system","volume":"17","author":"Chan","year":"2022","journal-title":"PLoS One"},{"key":"2026082007453362000_16.8.e118951.55","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.21019","article-title":"Health Care Utilization Following Interventions to Improve Social Well-Being: A Systematic Review and Meta-analysis","volume":"6","author":"HaGani","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2026082007453362000_16.8.e118951.56","doi-asserted-by":"crossref","DOI":"10.1186\/s12888-018-1837-1","article-title":"Factors associated with health service utilisation for common mental disorders: a systematic review","volume":"18","author":"Roberts","year":"2018","journal-title":"BMC Psychiatry"},{"key":"2026082007453362000_16.8.e118951.57","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2017.304180"},{"key":"2026082007453362000_16.8.e118951.58","doi-asserted-by":"crossref","first-page":"815660","DOI":"10.3389\/fmed.2022.815660","article-title":"A systematic review protocol for assessing equity in clinical practice guidelines for traumatic brain injury and homelessness","volume":"9","author":"Chan","year":"2022","journal-title":"Front Med"},{"key":"2026082007453362000_16.8.e118951.59","article-title":"Guidance on the conduct of narrative synthesis in systematic reviews","volume":"1","author":"Popay","year":"2006","journal-title":"Prod ESRC Methods Programme Version"},{"key":"2026082007453362000_16.8.e118951.60","unstructured":"National Heart, Lung, and Blood Institute . Study quality assessment tools. n.d. Available: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools"},{"key":"2026082007453362000_16.8.e118951.61","first-page":"229","article-title":"What Quality Assessment Tool Should I Use? A Practical Guide for Systematic Reviews Authors","volume":"48","author":"Delavari","year":"2023","journal-title":"Iran J Med Sci"},{"key":"2026082007453362000_16.8.e118951.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.09.044"},{"key":"2026082007453362000_16.8.e118951.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29903-3"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2026-118951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:03Z","timestamp":1787237163000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2026-118951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/bmjopen-2026-118951"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2026-118951","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}