{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:12:41Z","timestamp":1788358361186,"version":"build-2803163510"},"reference-count":18,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"unspecified","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,7,2]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a common chronic condition requiring long-term management, for which shared decision-making is increasingly recognised as an important component of care. Stated preference (SP) methods, including discrete choice experiments (DCE), conjoint analysis (CA) and best\u2013worst scaling (BWS), are increasingly used to quantify patient preferences for treatment attributes and to inform clinical and policy decisions. However, evidence from SP studies in OA has not been comprehensively synthesised. This protocol describes a systematic review aiming to identify, appraise and synthesise evidence on the relative importance of treatment attributes for patients with OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A comprehensive search will be conducted in PubMed, Embase, CINAHL, Scopus, Dimensions and OpenAlex from database inception to January 2026. Eligible studies will include quantitative SP studies\u2014encompassing DCE, CA and BWS\u2014evaluating patient preferences for pharmacological, non-pharmacological or surgical treatments in OA. Two reviewers will independently screen studies, extract data using a standardised form and assess methodological quality using the Purpose, Respondents, Explanation, Findings and Significance (PREFS) checklist, the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Good Research Practices for CA and DCE and the DIscrete choice experiment REporting ChecklisT (DIRECT) checklist for reporting quality. A structured narrative synthesis will summarise and categorise key treatment attributes (eg, efficacy, safety, cost and mode of administration). Where studies are sufficiently comparable in attributes and outcome reporting, a random-effects meta-analysis may be conducted to pool preference estimates, such as relative importance or willingness-to-pay values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval is not required, as this review will use published data only. Findings will be disseminated through peer-reviewed publication and conference presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD420251181273.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-119054","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:20:11Z","timestamp":1783682411000},"page":"e119054","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Patient preferences for treatment attributes in osteoarthritis: protocol for a systematic review of stated preference studies"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1199-1784","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Normal University Tianhua College, Shanghai, China"},{"name":"Te Kura M\u0101tauranga Koiora - School of Biological Sciences, Te Herenga Waka - Victoria University of Wellington, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-2525","authenticated-orcid":false,"given":"Tara","family":"Officer","sequence":"additional","affiliation":[{"name":"Te Puna Hauora - School of Health, Te Herenga Waka - Victoria University of Wellington, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-9258","authenticated-orcid":false,"given":"Mickael","family":"Hiligsmann","sequence":"additional","affiliation":[{"name":"Te Kura M\u0101tauranga Koiora - School of Biological Sciences, Te Herenga Waka - Victoria University of Wellington, Wellington, New Zealand"},{"name":"Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-4961","authenticated-orcid":false,"given":"Elaine","family":"Dennison","sequence":"additional","affiliation":[{"name":"Te Kura M\u0101tauranga Koiora - School of Biological Sciences, Te Herenga Waka - Victoria University of Wellington, Wellington, New Zealand"},{"name":"MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026071004200654000_16.7.e119054.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203355"},{"key":"2026071004200654000_16.7.e119054.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.44"},{"key":"2026071004200654000_16.7.e119054.3","unstructured":"Wennberg JE . Preference-sensitive care: a dartmouth atlas project topic brief. In: Lebanon (NH): The Dartmouth institute for health policy and clinical practice. 2007. Available: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK586631\/ [Accessed 29 Apr 2026]."},{"key":"2026071004200654000_16.7.e119054.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-1-200401060-00012"},{"key":"2026071004200654000_16.7.e119054.5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jval.2025.08.016","article-title":"Unlocking Patient Preferences: The Potential of Stated-Preference Methods in Clinical Decision Making","volume":"29","author":"Ozdemir","year":"2026","journal-title":"Value Health"},{"key":"2026071004200654000_16.7.e119054.6","first-page":"55","article-title":"Using discrete choice experiments to value health care programmes: current practice and future research reflections","volume":"2","author":"Ryan","year":"2003","journal-title":"Appl Health Econ Health Policy"},{"key":"2026071004200654000_16.7.e119054.7","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200826080-00004"},{"key":"2026071004200654000_16.7.e119054.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40520-018-1098-3","article-title":"Patients\u2019 preferences for osteoarthritis treatment: the value of stated-preference studies","volume":"31","author":"Hiligsmann","year":"2019","journal-title":"Aging Clin Exp Res"},{"key":"2026071004200654000_16.7.e119054.9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/j.pain.0000000000002775","article-title":"Patient preferences in the treatment of chronic musculoskeletal pain: a systematic review of discrete choice experiments","volume":"164","author":"Zhu","year":"2023","journal-title":"Pain"},{"key":"2026071004200654000_16.7.e119054.10","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"2026071004200654000_16.7.e119054.11","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2026071004200654000_16.7.e119054.12","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-020-01542-z","article-title":"PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews","volume":"10","author":"Rethlefsen","year":"2021","journal-title":"Syst Rev"},{"key":"2026071004200654000_16.7.e119054.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.01.021"},{"key":"2026071004200654000_16.7.e119054.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.11.013"},{"key":"2026071004200654000_16.7.e119054.15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jval.2016.04.004","article-title":"Statistical Methods for the Analysis of Discrete Choice Experiments: A Report of the ISPOR Conjoint Analysis Good Research Practices Task Force","volume":"19","author":"Hauber","year":"2016","journal-title":"Value Health"},{"key":"2026071004200654000_16.7.e119054.16","doi-asserted-by":"publisher","DOI":"10.1007\/S40273-024-01431-6"},{"key":"2026071004200654000_16.7.e119054.17","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6963-14-367","article-title":"The use of discrete choice experiments to inform health workforce policy: a systematic review","volume":"14","author":"Mandeville","year":"2014","journal-title":"BMC Health Serv Res"},{"key":"2026071004200654000_16.7.e119054.18","unstructured":"Popay J , Roberts H , Sowden A , et al . Guidance on the conduct of narrative synthesis in systematic reviews. 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