{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:50:42Z","timestamp":1791827442358,"version":"4.3.4"},"reference-count":25,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"unspecified","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"XPRIZE Healthspan"},{"name":"TSI Pharmaceuticals"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,9,30]]},"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1136\/bmjopen-2026-119962","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:25:42Z","timestamp":1791825942000},"page":"e119962","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) and\/or 2-hydroxybenzylamine (2-HOBA) on markers of healthspan in older adults (H2AGE trial): study protocol of a randomised controlled trial at the Canadian Translational Geroscience Network"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct07419633","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct07419633","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-1030","authenticated-orcid":false,"given":"Guy","family":"Hajj-Boutros","sequence":"first","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"},{"name":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Birtulescu","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Balram","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Faust","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Roussel","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Bernier","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Sun","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vaugeois","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C","family":"Vinh","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Morais","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"},{"name":"Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-5461","authenticated-orcid":false,"given":"Tyler A","family":"Churchward-Venne","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"},{"name":"Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kremer","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Gouspillou","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences de l\u2019Activit\u00e9 Physique, UQAM, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naji","family":"Abumrad","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rathmacher","sequence":"additional","affiliation":[{"name":"TSI Group Ltd, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Candow","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Health Studies, University of Regina, Regina, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Watt","sequence":"additional","affiliation":[{"name":"Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero-Odasso","sequence":"additional","affiliation":[{"name":"Medicine (Geriatrics) and Epidemiology and Biostatistics, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"McGlory","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Studies, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-0637","authenticated-orcid":false,"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"},{"name":"Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"2026101210252742000_16.10.e119962.1","doi-asserted-by":"crossref","DOI":"10.1186\/2049-3258-72-45","article-title":"Sarcopenia: burden and challenges for public health","volume":"72","author":"Beaudart","year":"2014","journal-title":"Arch Public Health"},{"key":"2026101210252742000_16.10.e119962.2","unstructured":"World Health Organization . WHO european regional obesity report 2022. Regional Office for Europe; 2022."},{"key":"2026101210252742000_16.10.e119962.3","article-title":"Age-related decline in peak oxygen uptake: Cross-sectional vs. longitudinal findings. A review","volume":"16","author":"Letnes","year":"2023","journal-title":"Int J Cardiol Cardiovasc Risk Prev"},{"key":"2026101210252742000_16.10.e119962.4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Sig Transduct Target Ther"},{"key":"2026101210252742000_16.10.e119962.5","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"2026101210252742000_16.10.e119962.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2010.04.014"},{"key":"2026101210252742000_16.10.e119962.7","doi-asserted-by":"crossref","DOI":"10.3390\/nu11092082","article-title":"Health Benefits of \u03b2-Hydroxy-\u03b2-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis","volume":"11","author":"Courel-Ib\u00e1\u00f1ez","year":"2019","journal-title":"Nutrients"},{"key":"2026101210252742000_16.10.e119962.8","doi-asserted-by":"crossref","DOI":"10.1080\/15502783.2024.2434734","article-title":"International society of sports nutrition position stand: \u03b2-hydroxy-\u03b2-methylbutyrate (HMB)","volume":"22","author":"Rathmacher","year":"2025","journal-title":"J Int Soc Sports Nutr"},{"key":"2026101210252742000_16.10.e119962.9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12603-023-1911-1","article-title":"Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Older Adults with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"27","author":"Yang","year":"2023","journal-title":"J Nutr Health Aging"},{"key":"2026101210252742000_16.10.e119962.10","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/gerona\/glaa218","article-title":"Long-term Effects of Calcium \u03b2-Hydroxy-\u03b2-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study","volume":"75","author":"Rathmacher","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026101210252742000_16.10.e119962.11","doi-asserted-by":"crossref","first-page":"107418","DOI":"10.1016\/j.pharmthera.2019.107418","article-title":"Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions","volume":"205","author":"Davies","year":"2020","journal-title":"Pharmacol Ther"},{"key":"2026101210252742000_16.10.e119962.12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40360-020-0382-y","article-title":"Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial","volume":"21","author":"Pitchford","year":"2020","journal-title":"BMC Pharmacol Toxicol"},{"key":"2026101210252742000_16.10.e119962.13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s10753-023-01801-w","article-title":"Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans","volume":"46","author":"Rathmacher","year":"2023","journal-title":"Inflammation"},{"key":"2026101210252742000_16.10.e119962.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0675-0"},{"key":"2026101210252742000_16.10.e119962.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.005"},{"key":"2026101210252742000_16.10.e119962.16","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.clnu.2018.09.025","article-title":"A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults","volume":"38","author":"Din","year":"2019","journal-title":"Clin Nutr"},{"key":"2026101210252742000_16.10.e119962.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.08.007"},{"key":"2026101210252742000_16.10.e119962.18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-018-0281-7","article-title":"First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers","volume":"20","author":"Pitchford","year":"2019","journal-title":"BMC Pharmacol Toxicol"},{"key":"2026101210252742000_16.10.e119962.19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00045.2014"},{"key":"2026101210252742000_16.10.e119962.20","doi-asserted-by":"publisher","DOI":"10.1159\/000534063"},{"key":"2026101210252742000_16.10.e119962.21","unstructured":"Lezak MD . Neuropsychological assessment. Oxford university press; 2004."},{"key":"2026101210252742000_16.10.e119962.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.02.007"},{"key":"2026101210252742000_16.10.e119962.23","unstructured":"Ware JE , Kosinski MA , Keller SD . SF-36 physical and mental health summary scales: A user\u2019s manual: Health Inst. New England Med 1995."},{"key":"2026101210252742000_16.10.e119962.24","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glae069","article-title":"Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions","volume":"79","author":"Hajj-Boutros","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026101210252742000_16.10.e119962.25","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf111","article-title":"Foundations and Strategic Vision of the Canadian Translational Geroscience Network","volume":"80","author":"Hajj-Boutros","year":"2025","journal-title":"J Gerontol A Biol Sci Med Sci"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2026-119962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:25:46Z","timestamp":1791825946000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2026-119962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,12]]},"published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1136\/bmjopen-2026-119962"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2026-119962","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]}}}