{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:02:17Z","timestamp":1790182937451,"version":"4.1.0"},"reference-count":33,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sanming Project of Medicine in ShenZhen NanShan","award":["202408"],"award-info":[{"award-number":["202408"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,9,1]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Shenzhen Birth Cohort (SZBC) is an ongoing prospective study established to investigate the impact of genetic, environmental and lifestyle factors on maternal health and child development in Shenzhen, a metropolis characterised by rapid economic development and a high density of young migrants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Since March 2018, pregnant women (\u226419 weeks of gestation) have been recruited from Nanshan Maternity &amp; Child Healthcare Hospital of Shenzhen. Follow-up assessments are conducted at up to 20 time points from early pregnancy through delivery and childhood (up to 7 years of age). Extensive health data were collected through standardised questionnaires, physical examinations and biological samples (eg, blood, urine, faeces).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>As of December 2025, 4208 pregnant women were enrolled, of whom 3962 completed baseline data collection and constituted the baseline cohort; 3150 deliveries had been recorded. Preliminary findings included the following: (1) Maternal lifestyles and adverse birth outcomes: poor sleep quality in early pregnancy was associated with higher risks of small-for-gestational-age (SGA). (2) Maternal health conditions and neurodevelopment: higher pre-pregnancy BMI was associated with developmental delays in offspring, particularly in boys. (3) Environmental exposures and neurodevelopment: prenatal exposure to greenness was associated with higher levels of motor development, whereas postnatal PM\u2082.\u2085 exposure (notably nitrate) was associated with increased risks of delayed motor and problem-solving development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>Recruitment is planned to continue through 2028, with enrolled children undergoing regular follow-up through 7 years of age. The current phase of cohort follow-up is expected to be completed in 2035. Future studies will integrate electronic medical records and multi-omics data to examine the combined effects of early-life exposures and explore potential biological pathways related to maternal and child health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-121066","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:11:28Z","timestamp":1790179888000},"page":"e121066","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cohort profile: the Shenzhen Birth Cohort (SZBC) study"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-7070","authenticated-orcid":false,"given":"Xiuxiu","family":"Li","sequence":"first","affiliation":[{"name":"Nanshan Maternity & Child Healthcare Hospital of Shenzhen, ShenZhen, 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