{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:06:15Z","timestamp":1789571175555,"version":"build-2803163510"},"reference-count":32,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"unspecified","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2025ZD0546200"],"award-info":[{"award-number":["2025ZD0546200"]}]},{"name":"Beijing Outstanding Young Scientist Program","award":["JWZQ20240101023"],"award-info":[{"award-number":["JWZQ20240101023"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,8,19]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) is imposing an increasing public health and socioeconomic burden. In China, rapid population ageing is sharply increasing disease burden. Previous studies have shown that AD-related costs are mainly driven by long-term informal care. However, evidence in China remains limited by an incomplete cost framework and insufficient consideration of caregivers\u2019 burden and indirect costs. Notably, the National Dementia Action Plan (2024\u20132030), issued by the Chinese government, marks a major shift to early detection and comprehensive care of AD, highlighting the urgent need for nationally representative economic evidence to support policy implementation. This study aims to evaluate the economic burden and quality of life of patients with AD and their caregivers in mainland China, and is the first nationwide study to include individuals with amnestic mild cognitive impairment, providing foundational data for future health technology assessment of early AD interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics will be presented and compared using t-tests or \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests. Economic burden will be estimated by calculating the per capita cost and weighted national total based on provincial numbers of patients with AD. Indirect costs will be assessed using locally adapted replacement cost approach and forgone wages approach. The analysis will be stratified by disease severity and age. Future burden will be projected by linking data from China Statistical Yearbook 2025 and the UN World Population Prospects 2024. Unmet care needs, AD-related catastrophic health expenditure and AD dependency ratio (ADDR) will also be assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      Ethics approval was obtained from the Ethics Committee of Xuanwu Hospital, Capital Medical University (No. 2023132). The study has been registered at ClinicalTrials.gov (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05995418\">NCT05995418<\/jats:ext-link>\n                      ) and the Chinese Clinical Trial Registry (ChiCTR2300074723). The results from this study will be actively disseminated through research articles and conference presentations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration numbers<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05995418\">NCT05995418<\/jats:ext-link>\n                      ; ChiCTR2300074723.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-122035","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:55:30Z","timestamp":1789570530000},"page":"e122035","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Alzheimer\u2019s disease burden in China (ABC) study: protocol for a nationwide multicentre cross-sectional and prospective cohort study"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct05995418","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05995418","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05995418","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Yixuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-2061","authenticated-orcid":false,"given":"Qi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Public Health, Peking University Health Science Center, Beijing, China"},{"name":"Center for Healthy Aging Transdisciplinary Sciences, China Center for Health Development Studies, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Public Health, Peking University Health Science Center, Beijing, China"},{"name":"Center for Healthy Aging Transdisciplinary Sciences, China Center for Health Development Studies, Peking University, Beijing, China"},{"name":"Key Laboratory of 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