{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:04:40Z","timestamp":1789646680655,"version":"4.0.0"},"reference-count":28,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"unspecified","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hebei Medical Science Research Project","award":["No.20261440"],"award-info":[{"award-number":["No.20261440"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,9,1]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patent hemostasis (PH) is important for preventing radial artery occlusion after transradial coronary procedures, but the relative efficacy and safety of different PH-guided strategies remain uncertain. This study aims to compare and rank these strategies and, if data permit, explore the potential contributions of their key components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Nine databases (PubMed, Embase, CINAHL, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, VIP Database and the Chinese Biomedical Literature Database) will be searched from inception to 1 July 2026 for randomised controlled trials involving adults undergoing coronary intervention and diagnosis via transradial access. Supplementary searches will include trial registries, academic search engines and reference lists. Two reviewers will independently conduct study selection, data extraction, network node assignment, component coding and risk-of-bias assessment. Pairwise and frequentist network meta-analyses will be performed using R v4.4.1 under a random-effects framework. Heterogeneity, transitivity, inconsistency, small-study effects, certainty of evidence, subgroup effects and sensitivity will be assessed. Exploratory component network meta-analysis will be conducted using an additive model if data and network structure permit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study will analyse published aggregate data and will not involve participant recruitment, clinical intervention or collection of biological samples; therefore, ethical approval is not required. The findings will be disseminated through peer-reviewed publication and other relevant academic channels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>PROSPERO CRD420261436288.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-125309","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:45:37Z","timestamp":1789645537000},"page":"e125309","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of patent haemostasis-guided strategies for preventing radial artery occlusion following transradial coronary procedures: a protocol for a systematic review, network meta-analysis, and exploratory component network meta-analysis"],"prefix":"10.1136","volume":"16","author":[{"given":"Xiaoping","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology, No. 980 Hospital of PLA Joint Logistics Support Force, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, No. 980 Hospital of PLA Joint Logistics Support Force, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7996-4776","authenticated-orcid":false,"given":"Shuo","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Nursing, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, No. 980 Hospital of PLA Joint Logistics Support Force, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6531-2483","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, No. 980 Hospital of PLA Joint Logistics Support Force, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026091704452036000_16.9.e125309.1","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2024.11.009","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"85","author":"Rao","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"2026091704452036000_16.9.e125309.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"2026091704452036000_16.9.e125309.3","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.124.014186","article-title":"Procedural Outcomes With Femoral, Radial, Distal Radial, and Ulnar Access for Coronary Angiography: A Network Meta-Analysis","volume":"17","author":"Maqsood","year":"2024","journal-title":"Circ Cardiovasc Interv"},{"key":"2026091704452036000_16.9.e125309.4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1161\/CIRCULATIONAHA.122.061527","article-title":"Effects on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: Meta-Analysis of Individual Patient Data From 7 Multicenter Randomized Clinical Trials","volume":"146","author":"Gargiulo","year":"2022","journal-title":"Circulation"},{"key":"2026091704452036000_16.9.e125309.5","doi-asserted-by":"crossref","DOI":"10.3390\/jcdd10070283","article-title":"Preventing and Managing Radial Artery Occlusion following Transradial Procedures: Strategies and Considerations","volume":"10","author":"Tsigkas","year":"2023","journal-title":"J Cardiovasc Dev Dis"},{"key":"2026091704452036000_16.9.e125309.6","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1160459","article-title":"Prevention of radial artery occlusion with rivaroxaban after trans-radial access coronary procedures: The RIVARAD multicentric randomized trial","volume":"10","author":"Hammami","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2026091704452036000_16.9.e125309.7","doi-asserted-by":"crossref","DOI":"10.15420\/usc.2020.23","article-title":"Vascular Complications of Transradial Access for Cardiac Catheterization","volume":"15","author":"Riangwiwat","year":"2021","journal-title":"US Cardiol"},{"key":"2026091704452036000_16.9.e125309.8","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21639"},{"key":"2026091704452036000_16.9.e125309.9","doi-asserted-by":"crossref","unstructured":"Di Serafino L , Turturo M , Larosa C , et al . 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