{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:53:06Z","timestamp":1791096786085,"version":"4.1.0"},"reference-count":63,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"unspecified","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R01MD016003"],"award-info":[{"award-number":["R01MD016003"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54HD113291"],"award-info":[{"award-number":["U54HD113291"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2026,9,4]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Maternal morbidity and mortality in the USA disproportionately affect some women, including the Medicaid-insured, rural and Black, Hispanic and Native American populations. The drivers of disparities are complex and there is an urgent need for multilevel interventions focused on pregnancy-related and associated morbidity and mortality (PRAMM). This study will be the first large-scale test of community health worker inclusive home visiting and provider\/practice\/system level improvement strategies that support empowered patients, proactive providers and integrate community and clinical care designed to reduce PRAMM and disparities among women who are disproportionately affected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The primary study outcome will be rates of PRAMM\u2014a composite outcome including pregnancy-associated and pregnancy-related morbidity, severe maternal morbidity and mortality and disparities among women disproportionately affected. A quasi-experimental, stepped wedge design will be used. Participants will be Medicaid-insured women in three Michigan counties observed during pregnancy, at birth and up to 1 year post partum, who give birth between 2021 and 2028 (&gt;101\u2009000 births). Individual health outcomes will be assessed at three steps of the stepped-wedge design. Analyses will use a statewide linked data system including all Medicaid birth and death records, Medicaid claims and other programme data. In the context of Michigan extending pregnancy-related Medicaid, the study will evaluate the impact of the proposed multilevel intervention versus usual care from early pregnancy through 12 months post partum. The study was developed with full community engagement and participation including shared leadership with academic and community-based principal investigators representing intervention communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>An Institutional Review Board determined the study exempt from the human subject\u2019s regulations for the following reasons. Two of the three intervention components will not interact with human subjects to collect data\u2014we will only rely on secondary research using data or biospecimens not collected specifically for this study, and the data will be provided without identifiable information by someone without any role in this research study except providing the data. The third intervention component, medical provider surveys, is a benign behavioural intervention where information will be recorded using methods that prevent subjects\u2019 identities from being readily ascertained. Results will be published in peer-reviewed journals following Enhancing the QUAlity and Transparency Of Health Research (EQUATOR) guidelines. MSU IRB Study ID: STUDY00009358<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial \" xlink:href=\"NCT07025057\">NCT07025057<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2026-126045","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:24:42Z","timestamp":1791095082000},"page":"e126045","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Pragmatic trial of a multilevel community-centred intervention to reduce pregnancy-related and associated morbidity and mortality and disparities: a study protocol"],"prefix":"10.1136","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct07025057","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Cristian I","family":"Meghea","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7148-9198","authenticated-orcid":false,"given":"Hannah","family":"Bolder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-7213","authenticated-orcid":false,"given":"Jennifer E","family":"Johnson","sequence":"additional","affiliation":[{"name":"Charles Stewart Mott Department of Public Health, Michigan State University College of Human Medicine, Flint, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlydawn","family":"Wisdom","sequence":"additional","affiliation":[{"name":"Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Slaughter-Acey","sequence":"additional","affiliation":[{"name":"Gillings School of Public Health, The University of North Carolina, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-7309","authenticated-orcid":false,"given":"Peggy","family":"Vander Meulen","sequence":"additional","affiliation":[{"name":"Strong Beginnings - Healthy Start, Corewell Health West Michigan, Grand Rapids, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Sanchez Lloyd","sequence":"additional","affiliation":[{"name":"Strong Beginnings - Healthy Start, Corewell Health West Michigan, Grand Rapids, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E","family":"Raffo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5440-1312","authenticated-orcid":false,"given":"Hannah","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Anne","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026092908002600000_16.9.e126045.1","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S0140-6736(16)31470-2","article-title":"Global, regional, and national levels of maternal mortality, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Kassebaum","year":"2016","journal-title":"The Lancet"},{"key":"2026092908002600000_16.9.e126045.2","unstructured":"Declercq E , Zephyrin L , Fund C . 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