{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:01:05Z","timestamp":1793642465129,"version":"4.5.1"},"reference-count":40,"publisher":"BMJ","issue":"1","funder":[{"name":"Alberta Children's Hospital Research Institute, Alberta Children's Hospital Foundation"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Ophth"],"accepted":{"date-parts":[[2017,3,9]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the relationship between pre-eclampsia and development of retinopathy of prematurity (ROP) in infants with birth weight of &lt;1500 g and\/or gestation &lt;31 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study comprising infants born to mothers with pre-eclampsia between January 2007 and June 2010 at a single tertiary care centre. Their ROP outcome was compared with infants born to the next two normotensive mothers with a \u00b11\u2009week gestational age difference. Pearson \u03c7<jats:sup>2<\/jats:sup> test was used for categorical variables and Mann-Whitney U test was used for continuous variables. Multivariable regression was used to estimate the OR of ROP with prenatal pre-eclampsia exposure and adjust for confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 97 infants in the pre-eclampsia group, 27 (27%) developed ROP and of the 185 infants in the normotensive group, 50 (27%) developed ROP. On multivariable regression modelling, pre-eclampsia was not a risk factor for the development of ROP (OR 1.4, 95%\u2009CI 0.46 to 4.1). Gestational age, intrauterine growth restriction and blood transfusion were significant risk factors for the development of ROP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our cohort, pre-eclampsia was not a significant risk factor for the development of ROP. Intrauterine growth restricted infants of pre-eclamptic and normotensive mothers were at higher risk of ROP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjophth-2016-000049","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T20:10:29Z","timestamp":1497903029000},"page":"e000049","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Pre-eclampsia and the risk of retinopathy of prematurity in preterm infants with birth weight &lt;1500 g and\/or &lt;31 weeks\u2019 gestation"],"prefix":"10.1136","volume":"1","author":[{"given":"Belal","family":"Alshaikh","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Calgary Cumming School of Medicine, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Salman","sequence":"additional","affiliation":[{"name":"University of Toronto at Scarborough, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Calgary Cumming School of Medicine, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ells","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Calgary Cumming School of Medicine, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary Cumming School of Medicine, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"2025090110083510000_1.1.e000049.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.02.008"},{"key":"2025090110083510000_1.1.e000049.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208129"},{"key":"2025090110083510000_1.1.e000049.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0644"},{"key":"2025090110083510000_1.1.e000049.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.02.002"},{"key":"2025090110083510000_1.1.e000049.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9452-3"},{"key":"2025090110083510000_1.1.e000049.6","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0035"},{"key":"2025090110083510000_1.1.e000049.7","doi-asserted-by":"publisher","DOI":"10.1542\/neo.9-9-e411"},{"key":"2025090110083510000_1.1.e000049.8","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"2025090110083510000_1.1.e000049.9","unstructured":"MacDonald MG , Seshia MMK . 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