{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T17:10:10Z","timestamp":1756746610727,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Ophth"],"accepted":{"date-parts":[[2023,1,4]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To study the visual, refractive and surgical outcomes of intraocular lens (IOL) implantation versus aphakia in children with microspherophakia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective, comparative, non-randomised interventional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All consecutive children with microspherophakia who satisfied the inclusion criteria were included. The eyes that underwent in-the-bag IOL implantation and those that were left aphakic were included in groups A and B, respectively. The postoperative visual outcomes, IOL stability and complications during the follow-up period were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>22 eyes (13 patients, male 76%), of which 12 eyes were in group A and 10 eyes in group B. The mean\u00b1SE of age at surgery was 9.4\u00b11.4\u2009and 7.3\u00b10.9 years in group A and group B, respectively (p value 0.18). The mean follow-up of group A was 0.9\u00b10.4 years (median 0.5 years; Q1 0.04, Q3 2.16) and group B was 1.3\u00b10.9 years (median 0.147 years; Q1 0.08, Q3 0.39) (p value 0.76). All the baseline biometric variables including best-corrected visual acuity (BCVA) were comparable in each group. The final BCVA in logMAR adjusted for follow-up was comparable in both group A (0.29\u00b10.06) and group B (0.52\u00b10.09) (p value 0.06). Mean predictive error of IOL power in microspherophakia was 0.17\u00b10.43.<\/jats:p>\n                  <jats:p>The most common complication in group A was visual axis opacification of two eyes (16.7%, 95%\u2009CI 2.9% to 49.1%), of which one eye (8.3%, 95%\u2009CI 0.4% to 40.2%) needed membranectomy. Vitreous in anterior chamber was the most common complication in group B, seen in two eyes (20%, 95%\u2009CI 3.5% to 55.8%), of which one eye (10%, 95%\u2009CI 0.5% to 45.9%) underwent YAG laser vitreolysis. The survival analysis (p value 0.18) was comparable in each group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In-the-bag IOL is an option, which can be considered in selected cases of microspherophakia in developing nations where regular follow-up and economic constraints are a major concern.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjophth-2022-001049","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T10:55:26Z","timestamp":1673434526000},"page":"e001049","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Visual outcomes and safety profile of intraocular lens implantation versus aphakia in children with microspherophakia with no subluxation"],"prefix":"10.1136","volume":"8","author":[{"given":"Goura","family":"Chattannavar","sequence":"first","affiliation":[{"name":"Pediatric and Neuro-ophthalmology Services, Jasti V Ramanamma Children's Eye Care Centre, Child Sight Institute, L V Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-4930","authenticated-orcid":false,"given":"Ashik","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Henry Stewart Talks Ltd, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwesh","family":"Malgi","sequence":"additional","affiliation":[{"name":"Pediatric and Neuro-ophthalmology Services, Jasti V Ramanamma Children's Eye Care Centre, Child Sight Institute, L V Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-2300","authenticated-orcid":false,"given":"Ramesh","family":"Kekunnaya","sequence":"additional","affiliation":[{"name":"Pediatric and Neuro-ophthalmology Services, Jasti V Ramanamma Children's Eye Care Centre, Child Sight Institute, L V Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"2025090109324239000_8.1.e001049.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2002.tb03085.x"},{"key":"2025090109324239000_8.1.e001049.2","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1097\/j.jcrs.0000000000000334","article-title":"Diagnosis and treatment of microspherophakia","volume":"46","author":"Yu","year":"2020","journal-title":"J Cataract Refract Surg"},{"key":"2025090109324239000_8.1.e001049.3","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3182707437"},{"key":"2025090109324239000_8.1.e001049.4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/eye.2014.250","article-title":"Visual outcome and incidence of glaucoma in patients with microspherophakia","volume":"29","author":"Muralidhar","year":"2015","journal-title":"Eye"},{"key":"2025090109324239000_8.1.e001049.5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.4103\/0301-4738.129787","article-title":"Scleral-fixated intraocular lens implantation in microspherophakia","volume":"62","author":"Subbiah","year":"2014","journal-title":"Indian J Ophthalmol"},{"key":"2025090109324239000_8.1.e001049.6","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jcrs.2009.08.043","article-title":"Iris-fixated phakic intraocular lens implantation for correction of high myopia in microspherophakia","volume":"36","author":"Moshirfar","year":"2010","journal-title":"J Cataract Refract Surg"},{"key":"2025090109324239000_8.1.e001049.7","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307298"},{"key":"2025090109324239000_8.1.e001049.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2012.06.003"},{"key":"2025090109324239000_8.1.e001049.9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0886-3350(02)01617-6","article-title":"Phacoemulsification in a case of microspherophakia","volume":"29","author":"Khokhar","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"2025090109324239000_8.1.e001049.10","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jcrs.2012.05.001","article-title":"Vitrectorhexis and lens aspiration with posterior chamber intraocular lens implantation in spherophakia","volume":"38","author":"Al-Haddad","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"2025090109324239000_8.1.e001049.11","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000021937","article-title":"Visual quality observation of clear lens extraction by ultrasonic phacoemulsification and intraocular lens implantation in a child with microspherophakia: a case report","volume":"99","author":"Liu","year":"2020","journal-title":"Medicine"},{"key":"2025090109324239000_8.1.e001049.12","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.58477"},{"key":"2025090109324239000_8.1.e001049.13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3126\/mjsbh.v14i2.13381","article-title":"Clear lens extraction with foldable intraocular lens implantation in a case of isolated microspherophakia","volume":"14","author":"Shrestha","year":"2015","journal-title":"Medical Journal of Shree Birendra Hospital"},{"key":"2025090109324239000_8.1.e001049.14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5935\/0004-2749.20190012","article-title":"Bilateral clear lens extraction and intraocular lens implantation in a child with microspherophakia and Marfan syndrome","volume":"82","author":"Farat","year":"2019","journal-title":"Arq Bras Oftalmol"}],"container-title":["BMJ Open Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjophth-2022-001049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:32:51Z","timestamp":1756744371000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjophth.bmj.com\/lookup\/doi\/10.1136\/bmjophth-2022-001049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,11]]},"published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1136\/bmjophth-2022-001049"],"URL":"https:\/\/doi.org\/10.1136\/bmjophth-2022-001049","relation":{},"ISSN":["2397-3269"],"issn-type":[{"type":"electronic","value":"2397-3269"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}