{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:47:30Z","timestamp":1787226450681,"version":"build-2736575974"},"reference-count":36,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Ophth"],"accepted":{"date-parts":[[2022,10,25]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>To facilitate the integration of eye care into universal health coverage, the WHO is developing a Package of Eye Care Interventions (PECI). Development of the PECI involves the identification of evidence-based interventions from relevant clinical practice guidelines (CPGs) for uveitis.<\/jats:p>\n               <jats:p>A systematic review of CPGs published on uveitis between 2010 and March 2020 was conducted. CPGs passing title and abstract and full-text screening were evaluated using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and data on recommended interventions extracted using a standard data extraction sheet.<\/jats:p>\n               <jats:p>Of 56 CPGs identified as potentially relevant from the systematic literature search, 3 CPGs underwent data extraction following the screening stages and appraisal with the AGREE II tool. These CPGs covered screening for, monitoring and treating juvenile idiopathic arthritis (JIA)-associated uveitis, the use of adalimumab and dexamethasone in treating non-infectious uveitis, and a top-level summary of assessment, differential diagnosis and referral recommendations for uveitis, aimed at primary care practitioners. Many of the recommendations were based on expert opinion, though some incorporated clinical study and randomised controlled trial data.<\/jats:p>\n               <jats:p>There is currently sparse coverage of the spectrum of disease caused by uveitis within CPGs. This may partially be due to the large number of conditions with diverse causes and clinical presentations covered by the umbrella term uveitis, which makes numerous sets of guidelines necessary. The limited pool of CPGs to select from has implications for clinicians seeking guidance on clinical care strategies for uveitis.<\/jats:p>","DOI":"10.1136\/bmjophth-2022-001091","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T10:51:28Z","timestamp":1672915888000},"page":"e001091","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Systematic review of clinical practice guidelines for uveitis"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-2419","authenticated-orcid":false,"given":"Nima","family":"Ghadiri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK"},{"name":"Department of Eye and Vision Science, University of Liverpool, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R","family":"Reekie","sequence":"additional","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Gordon","sequence":"additional","affiliation":[{"name":"Centre for Public Health, Queen's University Belfast, Belfast, UK"},{"name":"International Centre for Eye Health, London School of Hygiene and Tropical Medicine International Centre for Eye Health, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sare","family":"Safi","sequence":"additional","affiliation":[{"name":"Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-0733","authenticated-orcid":false,"given":"Gareth","family":"Lingham","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Ireland, Technological University Dublin, Dublin, Ireland"},{"name":"Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R","family":"Evans","sequence":"additional","affiliation":[{"name":"Centre for Public Health, Queen\u2019s University Belfast UK, Belfast, UK"},{"name":"International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-348X","authenticated-orcid":false,"given":"Stuart","family":"Keel","sequence":"additional","affiliation":[{"name":"Department of Noncommunicable Diseases, Vision and Blindness Prevention Programme, World Health Organization, Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"2025090109591108000_8.1.e001091.1","unstructured":"World Health Organization . 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