{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T17:10:13Z","timestamp":1756746613389,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Assistance Publique- H\u00f4pitaux de Paris, French Ministry of Health.","award":["AOM09123 \u2013 NI08014 - IDR-CB 2010-A00512-37"],"award-info":[{"award-number":["AOM09123 \u2013 NI08014 - IDR-CB 2010-A00512-37"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Ophth"],"accepted":{"date-parts":[[2024,9,3]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To better characterise the effects of corticosteroids on the course of pure idiopathic orbital inflammation syndrome (pIOIS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a national, multicentre, prospective, non-interventional cohort study (<jats:italic>SIOI<\/jats:italic>). Among the 35 patients with histologically proven orbital inflammation who had previously been studied for their IgG4 immunostaining status, we selected those with a negative IgG4 status (ie, pIOIS) who received corticosteroids as single first-line treatment. Clinical, morphological and pathological findings at diagnosis and during follow-up from treatment initiation to study completion were analysed. Patients were assessed for their response to prednisone after the 24-month prospective phase in terms of remission (\u226410\u2009mg\/d) or failure (&gt;10\u2009mg\/d). Daily standard doses of prednisone (DSDP) were calculated at different time-points and compared between response groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 17 patients with pIOIS included in the final analysis, two-thirds received corticosteroids only. DSDP (mg\/kg-day) were significantly higher at the time of failure in eight patients (47%) than in nine (53%) remitting at M24 (0.16 vs 0.045; p: 0.03). Notably, patients with pIOIS with a cellular pattern or orbital fat involvement tended to receive higher daily corticosteroid doses in the event of failure than remission (0.16 vs 0.045 and 0.12 vs 0.042, respectively). During treatment, maximal DSDP was 0.52 in failed patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The highest corticosteroid doses were insufficient to prevent failure in patients with pIOIS, particularly in those with a cellular pattern or orbital fat involvement. Large-scale interventional studies are now necessary to clarify prognostic factors and optimise corticosteroid management in patients with pIOIS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjophth-2024-001663","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T08:45:14Z","timestamp":1727081114000},"page":"e001663","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cellular pattern and orbital fat involvement are possible risk factors for the failure of corticosteroids in patients with pure idiopathic orbital inflammation syndrome: lessons from the French prospective <i>SIOI<\/i> cohort study (part II)"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct01443000","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ambre","family":"La Rosa","sequence":"first","affiliation":[{"name":"M\u00e9decine Interne, H\u00f4pital Avicenne, Assistance Publique-H\u00f4pitaux de Paris (APHP), Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Groh","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, Centre National de R\u00e9f\u00e9rence des Syndromes Hyper\u00e9osinophiliques (CEREO), H\u00f4pital Foch, Suresnes, France"},{"name":"Universit\u00e9 Versailles St-Quentin-en-Yvelines, Versailles, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Martin","sequence":"additional","affiliation":[{"name":"Anatomopathologie, H\u00f4pital Avicenne, APHP, Bobigny, France"},{"name":"Facult\u00e9 de M\u00e9decine SMBH, Universit\u00e9 Sorbonne Paris Nord, Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Tran Ba","sequence":"additional","affiliation":[{"name":"Radiologie, H\u00f4pital Avicenne, AP-HP, Bobigny, France"},{"name":"Imagerie, Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla","family":"Cucherousset","sequence":"additional","affiliation":[{"name":"Anatomopathologie, H\u00f4pital Avicenne, APHP, Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Mouriaux","sequence":"additional","affiliation":[{"name":"Ophtalmologie, Centre Hospitalier Universitaire de Rennes, Rennes, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Rennes 1, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neila","family":"Sedira","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"H\u00e9ron","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Galatoire","sequence":"additional","affiliation":[{"name":"Chirurgie Oculoplastique, Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Saadoun","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne, H\u00f4pital Piti\u00e9 Salp\u00e9tri\u00e8re, APHP, Paris, France"},{"name":"Universit\u00e9 Pierre et Marie Curie (UPMC), Paris 6, DHU I2B, Paris, France"},{"name":"Inserm UMRS 938, UPMC, Paris 6, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u00efcha","family":"Abbas","sequence":"additional","affiliation":[{"name":"Immunologie Biologique, H\u00f4pital Saint-Antoine, APHP, Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, UPMC, Paris 6, Paris, 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