{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:38:24Z","timestamp":1775065104924,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shanghai Children's Health Foundation, Children\u2019s Blood and Cancer Foundation","award":["202304-CBC"],"award-info":[{"award-number":["202304-CBC"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["bmjpo"],"accepted":{"date-parts":[[2026,3,12]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This multicentre, prospective study systematically evaluated health-related quality of life (HRQoL) in Chinese children with newly diagnosed immune thrombocytopaenia (ITP) using the disease-specific Kids\u2019 ITP Tools (KITs) scale. The study addresses a critical gap in longitudinal HRQoL data, particularly within South and East Asian paediatric populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 88 child self-reports, 215 parent proxy-reports and 303 parent-completed HRQoL assessments were collected from nine tertiary hospitals (2023 and 2025). HRQoL was measured using validated KITs scales (child self-report \u22657 years, parent proxy-report &lt;7 years) at diagnosis and 1-week, 1-month, 3-month and 12-month follow-ups. Clinical variables were systematically recorded. Analyses included internal consistency (Cronbach\u2019s \u03b1), mixed-effects models and Spearman correlation testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 88 self-reported children (mean age 9.2 years) and 215 parent proxy-reports (mean age 3.2 years). Major findings included: (1) significant parent-child discordance in HRQoL scores (mean difference 20.06 points at diagnosis, p&lt;0.001), with parents consistently reporting poorer HRQoL; (2) excellent scale reliability (parent \u03b1=0.944, child \u03b1=0.910); (3) no association between baseline platelet counts and HRQoL (all p&gt;0.05); (4) transient HRQoL reductions following bone marrow aspiration and glucocorticoid therapy and (5) age-specific patterns\u2014older children reported greater family-related distress (p=0.044), whereas parents of younger children reported greater procedural distress (p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study supports the cross-cultural validity and reliability of the KITs scale in paediatric ITP. It reveals marked parent-child discrepancies (20.06-point gap) likely influenced by cultural and psychosocial factors. These findings highlight the need for culturally informed family-centred psychosocial interventions and provide a foundation for international HRQoL comparisons and culturally adaptive clinical care models in paediatric haematology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjpo-2025-004331","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:36:00Z","timestamp":1775057760000},"page":"e004331","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Health-related quality of life in Chinese children with immune thrombocytopaenia: a multicentre study"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6288-3736","authenticated-orcid":false,"given":"Shuxian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Rheumatology and Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1890-5282","authenticated-orcid":false,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Oncology Discipline Group, The Key Laboratory of Pediatric Hematology and Oncology Diseases of Wenzhou, Department of Hematology and Oncology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihan","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Children's Hospital (Fujian Branch of Shanghai Children\u2019s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Rheumatology and Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Rheumatology and Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7291-8732","authenticated-orcid":false,"given":"Liyun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Rheumatology and Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Pediatrics, Second Hospital of Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-9213","authenticated-orcid":false,"given":"Biyun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[{"name":"People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuantao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Oncology Discipline Group, The Key Laboratory of Pediatric Hematology and Oncology Diseases of Wenzhou, Department of Hematology and Oncology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4349-3150","authenticated-orcid":false,"given":"Kaizhi","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Rheumatology and Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"2026040108351465000_10.1.e004331.1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances"},{"key":"2026040108351465000_10.1.e004331.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21616"},{"key":"2026040108351465000_10.1.e004331.3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3349\/ymj.2016.57.1.127","article-title":"High Remission Rate of Chronic Immune Thrombocytopenia in Children: Result of 20-Year Follow-Up","volume":"57","author":"Kim","year":"2016","journal-title":"Yonsei Med J"},{"key":"2026040108351465000_10.1.e004331.4","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"2026040108351465000_10.1.e004331.5","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood.2020006480","article-title":"An update on pediatric ITP: differentiating primary ITP, IPD, and PID","volume":"140","author":"Grace","year":"2022","journal-title":"Blood"},{"key":"2026040108351465000_10.1.e004331.6","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12813"},{"key":"2026040108351465000_10.1.e004331.7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/bjh.16751","article-title":"Fatigue in children and adolescents with immune thrombocytopenia","volume":"191","author":"Grace","year":"2020","journal-title":"Br J Haematol"},{"key":"2026040108351465000_10.1.e004331.8","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28840","article-title":"Fatigue perception in a cohort of children with chronic immune thrombocytopenia and their caregivers using the PedsQL MFS: Real\u2010life multicenter experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP)","volume":"68","author":"Lassandro","year":"2021","journal-title":"Pediatric Blood & Cancer"},{"key":"2026040108351465000_10.1.e004331.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01587.x"},{"key":"2026040108351465000_10.1.e004331.10","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.31758","article-title":"Treatment Landscape in Pediatric Immune Thrombocytopenia: Addressing Unmet Needs","volume":"72","author":"Azevedo","year":"2025","journal-title":"Pediatr Blood Cancer"},{"key":"2026040108351465000_10.1.e004331.11","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/pbc.25984","article-title":"A Phase 3, Randomized, Double\u2010Blind, Placebo\u2010Controlled Study to Determine the Effect of Romiplostim on Health\u2010Related Quality of Life in Children with Primary Immune Thrombocytopenia and Associated Burden in Their Parents","volume":"63","author":"Mathias","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"2026040108351465000_10.1.e004331.12","doi-asserted-by":"crossref","first-page":"2375177","DOI":"10.1080\/16078454.2024.2375177","article-title":"Patient-centric care in primary immune thrombocytopenia (ITP): shared decision-making and assessment of health-related quality of life","volume":"29","author":"Maitland","year":"2024","journal-title":"Hematology"},{"key":"2026040108351465000_10.1.e004331.13","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200301000-00011"},{"key":"2026040108351465000_10.1.e004331.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.037"},{"key":"2026040108351465000_10.1.e004331.15","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24257"},{"key":"2026040108351465000_10.1.e004331.16","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/ajh.27433","article-title":"Safety and efficacy of baricitinib in steroid-resistant or relapsed immune thrombocytopenia: An open-label pilot study","volume":"99","author":"Zhao","year":"2024","journal-title":"Am J Hematol"},{"key":"2026040108351465000_10.1.e004331.17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/09537104.2013.831065","article-title":"Health-related quality of life in adult patients with chronic immune thrombocytopenia in Serbia","volume":"25","author":"Suvajdzic","year":"2014","journal-title":"Platelets"},{"key":"2026040108351465000_10.1.e004331.18","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.106963"},{"key":"2026040108351465000_10.1.e004331.19","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-016-0445-3","article-title":"Health-related quality of life in children with chronic immune thrombocytopenia in China","volume":"14","author":"Zhang","year":"2016","journal-title":"Health Qual Life Outcomes"},{"key":"2026040108351465000_10.1.e004331.20","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajh.25479","article-title":"Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes","volume":"94","author":"Grace","year":"2019","journal-title":"Am J Hematol"},{"key":"2026040108351465000_10.1.e004331.21","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.276"},{"key":"2026040108351465000_10.1.e004331.22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1423-0410.2012.01636.x","article-title":"Management of children and adolescents with primary immune thrombocytopenia: controversies and solutions","volume":"104","author":"K\u00fchne","year":"2013","journal-title":"Vox Sang"},{"key":"2026040108351465000_10.1.e004331.23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1684031"},{"key":"2026040108351465000_10.1.e004331.24","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.698"},{"key":"2026040108351465000_10.1.e004331.25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bjh.13385","article-title":"Fatigue in immune thrombocytopenia","volume":"170","author":"Hill","year":"2015","journal-title":"Br J Haematol"},{"key":"2026040108351465000_10.1.e004331.26","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s00277-021-04590-0","article-title":"Romiplostim in children with newly diagnosed or persistent primary immune thrombocytopenia","volume":"100","author":"Grainger","year":"2021","journal-title":"Ann Hematol"},{"key":"2026040108351465000_10.1.e004331.27","doi-asserted-by":"crossref","DOI":"10.3390\/medicina56120667","article-title":"Immune Thrombocytopenia (ITP): Current Limitations in Patient Management","volume":"56","author":"Terrell","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"2026040108351465000_10.1.e004331.28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12098-019-03155-4","article-title":"Immune Thrombocytopenia in Children: Consensus and Controversies","volume":"87","author":"Singh","year":"2020","journal-title":"Indian J Pediatr"}],"container-title":["BMJ Paediatrics Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjpo-2025-004331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:36:03Z","timestamp":1775057763000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjpaedsopen.bmj.com\/lookup\/doi\/10.1136\/bmjpo-2025-004331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,4,1]]},"published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1136\/bmjpo-2025-004331"],"URL":"https:\/\/doi.org\/10.1136\/bmjpo-2025-004331","relation":{},"ISSN":["2399-9772"],"issn-type":[{"value":"2399-9772","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}