{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:29:22Z","timestamp":1792805362044,"version":"4.5.0"},"reference-count":94,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PB-PG-0711-25094"],"award-info":[{"award-number":["PB-PG-0711-25094"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Qual Saf"],"accepted":{"date-parts":[[2019,8,29]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To develop and validate a tool to predict the risk of an older adult experiencing medication-related harm (MRH) requiring healthcare use following hospital discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, setting, participants<\/jats:title>\n                  <jats:p>Multicentre, prospective cohort study recruiting older adults (\u226565 years) discharged from five UK teaching hospitals between 2013 and 2015.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary outcome measure<\/jats:title>\n                  <jats:p>Participants were followed up for 8 weeks in the community by senior pharmacists to identify MRH (adverse drug reactions, harm from non-adherence, harm from medication error). Three data sources provided MRH and healthcare use information: hospital readmissions, primary care use, participant telephone interview. Candidate variables for prognostic modelling were selected using two systematic reviews, the views of patients with MRH and an expert panel of clinicians. Multivariable logistic regression with backward elimination, based on the Akaike Information Criterion, was used to develop the PRIME tool. The tool was internally validated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>1116 out of 1280 recruited participants completed follow-up (87%). Uncertain MRH cases (\u2018possible\u2019 and \u2018probable\u2019) were excluded, leaving a tool derivation cohort of 818. 119 (15%) participants experienced \u2018definite\u2019 MRH requiring healthcare use and 699 participants did not. Modelling resulted in a prediction tool with eight variables measured at hospital discharge: age, gender, antiplatelet drug, sodium level, antidiabetic drug, past adverse drug reaction, number of medicines, living alone. The tool\u2019s discrimination C-statistic was 0.69 (0.66 after validation) and showed good calibration. Decision curve analysis demonstrated the potential value of the tool to guide clinical decision making compared with alternative approaches.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The PRIME tool could be used to identify older patients at high risk of MRH requiring healthcare use following hospital discharge. Prior to clinical use we recommend the tool\u2019s evaluation in other settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjqs-2019-009587","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T17:15:37Z","timestamp":1568654137000},"page":"142-153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Medication-related harm in older adults following hospital discharge: development and validation of a prediction tool"],"prefix":"10.1136","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-3717","authenticated-orcid":false,"given":"Nikesh","family":"Parekh","sequence":"first","affiliation":[{"name":"Academic Department of Geriatric Medicine, Brighton and Sussex Medical School, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Ali","sequence":"additional","affiliation":[{"name":"Academic Department of Geriatric Medicine, Brighton and Sussex Medical School, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Graham","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Banya","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Nyangoma","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Schiff","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tischa","family":"van der Cammen","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinder","family":"Harchowal","sequence":"additional","affiliation":[{"name":"Royal Marsden Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakravarthi","family":"Rajkumar","sequence":"additional","affiliation":[{"name":"Academic Department of Geriatric Medicine, Brighton and Sussex Medical School, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"2025090411571600000_29.2.142.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31047-4"},{"key":"2025090411571600000_29.2.142.2","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/jgs.15419","article-title":"Incidence of medication-related harm in older adults after hospital discharge: a systematic review","volume":"66","author":"Parekh","year":"2018","journal-title":"J Am Geriatr Soc"},{"key":"2025090411571600000_29.2.142.3","unstructured":"World Health Organization . Medication safety in transitions of care. Geneva, 2019."},{"key":"2025090411571600000_29.2.142.4","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12596"},{"key":"2025090411571600000_29.2.142.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02007.x"},{"key":"2025090411571600000_29.2.142.6","doi-asserted-by":"crossref","unstructured":"Gellad WF , Grenard JL , Marcum ZA . A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother 2011.","DOI":"10.1016\/j.amjopharm.2011.02.004"},{"key":"2025090411571600000_29.2.142.7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1369-7625.2011.00714.x","article-title":"'Seamless care? just a list would have helped!' older people and their carer's experiences of support with medication on discharge home from hospital","volume":"16","author":"Knight","year":"2013","journal-title":"Health Expect"},{"key":"2025090411571600000_29.2.142.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.1997.19970251233.x"},{"key":"2025090411571600000_29.2.142.9","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010035","article-title":"Medication-related burden and patients\u2019 lived experience with medicine: a systematic review and metasynthesis of qualitative studies","volume":"6","author":"Mohammed","year":"2016","journal-title":"BMJ Open"},{"key":"2025090411571600000_29.2.142.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1212324"},{"key":"2025090411571600000_29.2.142.11","first-page":"213","article-title":"Effect of medication reconciliation at hospital admission on medication discrepancies during hospitalization and at discharge","volume":"34","author":"Cornu","year":"2012","journal-title":"Int J Clin Pharm"},{"key":"2025090411571600000_29.2.142.12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/jcpt.12488","article-title":"Problems with continuity of care identified by community pharmacists post-discharge","volume":"42","author":"Ensing","year":"2017","journal-title":"J Clin Pharm Ther"},{"key":"2025090411571600000_29.2.142.13","doi-asserted-by":"crossref","unstructured":"Kattel S , Manning DM , Erwin PJ , et al . Information transfer at hospital discharge. J Patient Saf 2016;1.","DOI":"10.1097\/PTS.0000000000000248"},{"key":"2025090411571600000_29.2.142.14","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R022"},{"key":"2025090411571600000_29.2.142.15","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/bcp.13613","article-title":"Incidence and cost of medication harm in older adults following hospital discharge: a multicentre prospective study in the UK","volume":"84","author":"Parekh","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"2025090411571600000_29.2.142.16","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-019-3995-3","article-title":"A patient-centered deprescribing intervention for hospitalized older patients with polypharmacy: rationale and design of the Shed-MEDS randomized controlled trial","volume":"19","author":"Vasilevskis","year":"2019","journal-title":"BMC Health Serv Res"},{"key":"2025090411571600000_29.2.142.17","doi-asserted-by":"crossref","unstructured":"McDonald EG , Wu PE , Rashidi B , et al . The MedSafer study: a controlled trial of an electronic decision support tool for deprescribing in acute care. J Am Geriatr Soc 2019;170.doi:10.1111\/jgs.16040","DOI":"10.1111\/jgs.16040"},{"key":"2025090411571600000_29.2.142.18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2018-008233"},{"key":"2025090411571600000_29.2.142.19","unstructured":"England NHS . Next steps for risk stratification in the. London: NHS, 2015."},{"key":"2025090411571600000_29.2.142.20","unstructured":"Kivlahan C , Webster AM , Health AV , et al . High-Risk-Patient identification: strategies for success, 2016."},{"key":"2025090411571600000_29.2.142.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2010.04.001"},{"key":"2025090411571600000_29.2.142.22","doi-asserted-by":"crossref","unstructured":"Hippisley-Cox J , Coupland C , Brindle P . Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ 2017;357.doi:10.1136\/bmj.j2099","DOI":"10.1136\/bmj.j2099"},{"key":"2025090411571600000_29.2.142.23","doi-asserted-by":"crossref","unstructured":"Stevenson M , Williams L , Burnham G , et al . Predicting adverse drug reactions in older adults; a systematic review of the risk prediction models. Clin Interv Aging 2014;9.","DOI":"10.2147\/CIA.S65475"},{"key":"2025090411571600000_29.2.142.24","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1111\/bcp.13690","article-title":"Can doctors identify older patients at risk of medication harm following hospital discharge? A multicentre prospective study in the UK","volume":"84","author":"Parekh","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"2025090411571600000_29.2.142.25","doi-asserted-by":"crossref","unstructured":"Mangin D , Bahat G , Golomb BA , et al . International Group for Reducing Inappropriate Medication Use &amp; Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action. Drugs Aging 2018:1\u201313.","DOI":"10.1007\/s40266-018-0554-2"},{"key":"2025090411571600000_29.2.142.26","doi-asserted-by":"crossref","unstructured":"Stevenson J , Parekh N , Ali K , et al . Protocol for a prospective (P) study to develop a model to stratify the risk (RI) of medication (M) related harm in hospitalized elderly (E) patients in the UK (the prime study). BMC Geriatr 2016;16.doi:10.1186\/s12877-016-0191-8","DOI":"10.1186\/s12877-016-0191-8"},{"key":"2025090411571600000_29.2.142.27","doi-asserted-by":"crossref","unstructured":"Collins GS , Reitsma JB , Altman DG , et al . Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. Ann Intern Med 2015;162.","DOI":"10.7326\/L15-0078-4"},{"key":"2025090411571600000_29.2.142.28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1177\/106002809002401114","article-title":"Drug-Related problems: their structure and function","volume":"24","author":"Strand","year":"1990","journal-title":"DICP"},{"key":"2025090411571600000_29.2.142.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01326.x"},{"key":"2025090411571600000_29.2.142.30","first-page":"525","article-title":"Intensive monitoring for adverse drug effects in patients discharged from acute medical wards","volume":"78","author":"Kellaway","year":"1973","journal-title":"N Z Med J"},{"key":"2025090411571600000_29.2.142.31","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12504"},{"key":"2025090411571600000_29.2.142.32","article-title":"Adverse drug reactions in a population of hospitalized very elderly patients","volume":"29","author":"Tangiisuran","year":"2012","journal-title":"Drugs Aging"},{"key":"2025090411571600000_29.2.142.33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/bcp.12314","article-title":"Prevalence, nature and potential preventability of adverse drug events - a population-based medical record study of 4970 adults","volume":"78","author":"Hakkarainen","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"2025090411571600000_29.2.142.34","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.5.511"},{"key":"2025090411571600000_29.2.142.35","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025090411571600000_29.2.142.36","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198601000-00007"},{"key":"2025090411571600000_29.2.142.37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/ageing\/afy142","article-title":"\u2018 They must help if the doctor gives them to you\u2019 : a qualitative study of the older person\u2019s lived experience of medication-related problems","volume":"48","author":"Parekh","year":"2019","journal-title":"Age Ageing"},{"key":"2025090411571600000_29.2.142.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"2025090411571600000_29.2.142.39","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X0102100106"},{"key":"2025090411571600000_29.2.142.40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/bcp.13514","article-title":"Systematic review of predictive risk models for adverse drug events in hospitalized patients","volume":"84","author":"Falconer","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"2025090411571600000_29.2.142.41","doi-asserted-by":"crossref","DOI":"10.1186\/s12874-016-0267-3","article-title":"No rationale for 1 variable per 10 events criterion for binary logistic regression analysis","volume":"16","author":"van Smeden","year":"2016","journal-title":"BMC Med Res Methodol"},{"key":"2025090411571600000_29.2.142.42","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk052"},{"key":"2025090411571600000_29.2.142.43","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2003.011148"},{"key":"2025090411571600000_29.2.142.44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1996.tb03538.x"},{"key":"2025090411571600000_29.2.142.45","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"2025090411571600000_29.2.142.46","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b604","article-title":"Prognosis and prognostic research: developing a prognostic model","volume":"338","author":"Royston","year":"2009","journal-title":"BMJ"},{"key":"2025090411571600000_29.2.142.47","first-page":"289","article-title":"To explain or to predict?","volume":"24","author":"Schmueli","year":"2010","journal-title":"Stat Sci"},{"key":"2025090411571600000_29.2.142.48","doi-asserted-by":"crossref","unstructured":"Vatcheva KP , Lee M , Mccormick JB , et al . Multicollinearity in regression analyses conducted in epidemiologic studies HHS public access 2016.","DOI":"10.4172\/2161-1165.1000227"},{"key":"2025090411571600000_29.2.142.49","doi-asserted-by":"crossref","unstructured":"Alba AC , Agoritsas T , Walsh M , et al . Discrimination and calibration of clinical prediction models. JAMA 2017;318.","DOI":"10.1001\/jama.2017.12126"},{"key":"2025090411571600000_29.2.142.50","doi-asserted-by":"crossref","unstructured":"Pavlou M , Ambler G , Seaman SR , et al . How to develop a more accurate risk prediction model when there are few events. BMJ 2015;351.doi:10.1136\/bmj.h3868","DOI":"10.1136\/bmj.h3868"},{"key":"2025090411571600000_29.2.142.51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1198\/0003130043277","article-title":"Bootstrap methods for developing predictive models","volume":"58","author":"Austin","year":"2004","journal-title":"Am Stat"},{"key":"2025090411571600000_29.2.142.52","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu140"},{"key":"2025090411571600000_29.2.142.53","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00341-9"},{"key":"2025090411571600000_29.2.142.54","doi-asserted-by":"crossref","unstructured":"Vickers AJ , Van Calster B , Steyerberg EW . Net benefit approaches to the evaluation of prediction models, molecular markers, and diagnostic tests. BMJ 2016;352.doi:10.1136\/bmj.i6","DOI":"10.1136\/bmj.i6"},{"key":"2025090411571600000_29.2.142.55","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.eururo.2018.08.038","article-title":"Reporting and interpreting decision curve analysis: a guide for Investigators","volume":"74","author":"Van Calster","year":"2018","journal-title":"Eur Urol"},{"key":"2025090411571600000_29.2.142.56","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1177\/0962280214558972","article-title":"Events per variable (EPV) and the relative performance of different strategies for estimating the out-of-sample validity of logistic regression models","volume":"26","author":"Austin","year":"2017","journal-title":"Stat Methods Med Res"},{"key":"2025090411571600000_29.2.142.57","doi-asserted-by":"crossref","unstructured":"Alhawassi M , Krass I , Bajorek V , et al . A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting. Clin Interv Aging 2079;2014.","DOI":"10.2147\/CIA.S71178"},{"issue":"Supplement 1","key":"2025090411571600000_29.2.142.58","doi-asserted-by":"crossref","first-page":"i9","DOI":"10.1136\/qhc.0100009","article-title":"Understanding risk and lessons for clinical risk communication about treatment preferences","volume":"10","author":"Edwards","year":"2001","journal-title":"Qual Saf Heal Care"},{"key":"2025090411571600000_29.2.142.59","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c30fb2"},{"key":"2025090411571600000_29.2.142.60","doi-asserted-by":"crossref","unstructured":"O\u2019Mahony D , O\u2019Connor MN , Eustace J , et al . The adverse drug reaction risk in older persons (ADRROP) prediction scale: derivation and prospective validation of an ADR risk assessment tool in older multi-morbid patients. Eur Geriatr Med 2018:1\u20139.","DOI":"10.1007\/s41999-018-0030-x"},{"key":"2025090411571600000_29.2.142.61","doi-asserted-by":"crossref","unstructured":"Onder G , Petrovic M , Tangiisuran B , et al . Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older. Arch Intern Med 2010;170.doi:10.1001\/archinternmed.2010.153","DOI":"10.1001\/archinternmed.2010.153"},{"key":"2025090411571600000_29.2.142.62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165757","article-title":"Prediction of hospitalization due to adverse drug reactions in elderly community-dwelling patients (the PADR-EC score)","volume":"11","author":"Parameswaran Nair","year":"2016","journal-title":"PLoS One"},{"key":"2025090411571600000_29.2.142.63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111254","article-title":"Development and validation of a risk model for predicting adverse drug reactions in older people during hospital stay: Brighton adverse drug reactions risk (BADRI) model","volume":"9","author":"Tangiisuran","year":"2014","journal-title":"PLoS One"},{"key":"2025090411571600000_29.2.142.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurger.2011.07.002"},{"key":"2025090411571600000_29.2.142.65","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006376","article-title":"Determination of risk factors for drug-related problems: a multidisciplinary triangulation process","volume":"5","author":"Kaufmann","year":"2015","journal-title":"BMJ Open"},{"key":"2025090411571600000_29.2.142.66","doi-asserted-by":"crossref","unstructured":"Donz\u00e9 J , Aujesky D , Williams D , et al . Potentially avoidable 30-day Hospital readmissions in medical patients. JAMA Intern Med 2013;173.","DOI":"10.1001\/jamainternmed.2013.3023"},{"key":"2025090411571600000_29.2.142.67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02698.x"},{"key":"2025090411571600000_29.2.142.68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1103053"},{"key":"2025090411571600000_29.2.142.69","doi-asserted-by":"crossref","unstructured":"Malhotra S , Karan RS , Pandhi P , et al . Drug related medical emergencies in the elderly: role of adverse drug reactions and non-compliance. Postgrad Med J 2001;77.","DOI":"10.1136\/pmj.77.913.703"},{"key":"2025090411571600000_29.2.142.70","doi-asserted-by":"crossref","DOI":"10.1093\/eurpub\/ckw150","article-title":"Living alone and unplanned hospitalizations among older adults: a population-based longitudinal study","volume":"27","author":"Pimouguet","year":"2016","journal-title":"Eur J Public Health"},{"key":"2025090411571600000_29.2.142.71","doi-asserted-by":"crossref","unstructured":"Bragstad LK , Kirkevold M , Hofoss D , et al . Factors predicting a successful post-discharge outcome for individuals aged 80 years and over. Int J Integr Care 2012;12.doi:10.5334\/ijic.691","DOI":"10.5334\/ijic.691"},{"key":"2025090411571600000_29.2.142.72","doi-asserted-by":"crossref","DOI":"10.1001\/archinternmed.2009.513","article-title":"Impact of hospital-associated hyponatremia on selected outcomes","volume":"170","author":"Wald","year":"2010","journal-title":"Arch Intern Med"},{"key":"2025090411571600000_29.2.142.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.026"},{"key":"2025090411571600000_29.2.142.74","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/jcm3030944","article-title":"Hyponatremia: special considerations in older patients","volume":"3","author":"Soiza","year":"2014","journal-title":"JCM"},{"key":"2025090411571600000_29.2.142.75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001381","article-title":"Prognosis research strategy (progress) 3: prognostic model research","volume":"10","author":"Steyerberg","year":"2013","journal-title":"PLoS Med"},{"key":"2025090411571600000_29.2.142.76","doi-asserted-by":"crossref","first-page":"i27","DOI":"10.1093\/ageing\/afy202.03","article-title":"Frailty predicts medication-related harm requiring healthcare: a UK multicentre prospective cohort study","volume":"48","author":"Parekh","year":"2019","journal-title":"Age Ageing"},{"key":"2025090411571600000_29.2.142.77","doi-asserted-by":"crossref","unstructured":"Scutt G , Overall A , Bakrania P , et al . The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People. J Gerontol Ser A 2019;296.doi:10.1093\/gerona\/glz131","DOI":"10.1093\/gerona\/glz131"},{"key":"2025090411571600000_29.2.142.78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174513","article-title":"Cost-Effectiveness of a transitional pharmaceutical care program for patients discharged from the hospital","volume":"12","author":"Karapinar-\u00c7ark\u0131t","year":"2017","journal-title":"PLoS One"},{"key":"2025090411571600000_29.2.142.79","doi-asserted-by":"crossref","unstructured":"Thomas R , Huntley L , Mann M , et al . Pharmacist-Led interventions to reduce unplanned admissions for older people: a systematic review and meta-analysis of randomised controlled trials. Age Ageing 2014;43.","DOI":"10.1093\/ageing\/aft169"},{"key":"2025090411571600000_29.2.142.80","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2017-007087"},{"key":"2025090411571600000_29.2.142.81","doi-asserted-by":"crossref","unstructured":"Dhalla IA , O\u2019Brien T , Morra D , et al . Effect of a Postdischarge virtual ward on readmission or death for high-risk patients. JAMA 2014;312.doi:10.1001\/jama.2014.11492","DOI":"10.1001\/jama.2014.11492"},{"key":"2025090411571600000_29.2.142.82","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2014-000565"},{"key":"2025090411571600000_29.2.142.83","doi-asserted-by":"crossref","unstructured":"Bush J , Langley CA , Jenkins D , et al . Clinical pharmacists in general practice: an initial evaluation of activity in one English primary care organisation. Int J Pharm Pract 2017.","DOI":"10.1111\/ijpp.12426"},{"key":"2025090411571600000_29.2.142.84","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0140-6736(02)09421-7","article-title":"Communication of risk: choice, consent, and trust","volume":"360","author":"Calman","year":"2002","journal-title":"The Lancet"},{"key":"2025090411571600000_29.2.142.85","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X07307271"},{"key":"2025090411571600000_29.2.142.86","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0106-8"},{"key":"2025090411571600000_29.2.142.87","doi-asserted-by":"crossref","unstructured":"Hoffmann TC DMC . Patients\u2019 Expectations of the Benefits and Harms of Treatments, Screening, and Tests. JAMA Intern Med 2015;175.","DOI":"10.1001\/jamainternmed.2014.6016"},{"key":"2025090411571600000_29.2.142.88","doi-asserted-by":"crossref","DOI":"10.1001\/jamainternmed.2016.8254","article-title":"Clinicians\u2019 Expectations of the Benefits and Harms of Treatments, Screening, and Tests","volume":"177","author":"Hoffmann","year":"2017","journal-title":"JAMA Intern Med"},{"key":"2025090411571600000_29.2.142.89","unstructured":"GYH L . The CHA2DS2-VASc score for stroke risk stratification in patients with atrial fibrillation: a brief history. Eur Heart J 2015."},{"key":"2025090411571600000_29.2.142.90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001492","article-title":"Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50 Y or older: derivation and validation from population-based cohort studies","volume":"10","author":"Pfeiffer","year":"2013","journal-title":"PLoS Med"},{"key":"2025090411571600000_29.2.142.91","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091117"},{"key":"2025090411571600000_29.2.142.92","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-001667","article-title":"Development of a predictive model to identify inpatients at risk of re-admission within 30 days of discharge (PARR-30)","volume":"2","author":"Billings","year":"2012","journal-title":"BMJ Open"},{"key":"2025090411571600000_29.2.142.93","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr051"},{"key":"2025090411571600000_29.2.142.94","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"}],"container-title":["BMJ Quality &amp; Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjqs-2019-009587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T18:57:30Z","timestamp":1757012250000},"score":1,"resource":{"primary":{"URL":"https:\/\/qualitysafety.bmj.com\/lookup\/doi\/10.1136\/bmjqs-2019-009587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,16]]},"references-count":94,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,1,20]]},"published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1136\/bmjqs-2019-009587"],"URL":"https:\/\/doi.org\/10.1136\/bmjqs-2019-009587","relation":{},"ISSN":["2044-5415","2044-5423"],"issn-type":[{"value":"2044-5415","type":"print"},{"value":"2044-5423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,16]]}}}